Visualization of subcutaneous insulin injections by x-ray computed tomography
Thomsen, M. ; Poulsen, M. ; Bech, Martin LU
; Velroyen, A.
; Herzen, J.
; Beckmann, F.
; Feidenhans'l, R.
and Pfeiffer, F.
(2012)
In Physics in Medicine and Biology
57(21).
p.7191-7203
- Abstract
- We report how the three-dimensional structure of subcutaneous injections of soluble insulin can be visualized by x-ray computed tomography using an iodine based contrast agent. The injections investigated are performed ex vivo in porcine adipose tissue. Full tomography scans carried out at a laboratory x-ray source with a total acquisition time of about 1 min yield CT-images with an effective pixel size of 109 x 109 mu m(2). The depots are segmented using a modified Chan-Vese algorithm and we are able to observe differences in the shape of the injection depot and the position of the depot in the skin among equally performed injections. To overcome the beam hardening artefacts, which affect the quantitative prediction of the volume... (More)
- We report how the three-dimensional structure of subcutaneous injections of soluble insulin can be visualized by x-ray computed tomography using an iodine based contrast agent. The injections investigated are performed ex vivo in porcine adipose tissue. Full tomography scans carried out at a laboratory x-ray source with a total acquisition time of about 1 min yield CT-images with an effective pixel size of 109 x 109 mu m(2). The depots are segmented using a modified Chan-Vese algorithm and we are able to observe differences in the shape of the injection depot and the position of the depot in the skin among equally performed injections. To overcome the beam hardening artefacts, which affect the quantitative prediction of the volume injected, we additionally present results concerning the visualization of two injections using synchrotron radiation. The spatial concentration distribution of iodine is calculated to show the dilution of the insulin drug inside the depot. Characterisation of the shape of the depot and the spatial concentration profile of the injected fluid is important knowledge when improving the clinical formulation of an insulin drug, the performance of injection devices and when predicting the effect of the drug through biomedical simulations. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3256372
- author
- Thomsen, M.
; Poulsen, M.
; Bech, Martin
LU
; Velroyen, A.
; Herzen, J.
; Beckmann, F.
; Feidenhans'l, R.
and Pfeiffer, F.
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physics in Medicine and Biology
- volume
- 57
- issue
- 21
- pages
- 7191 - 7203
- publisher
- IOP Publishing
- external identifiers
-
- wos:000310528700032
- scopus:84868026819
- pmid:23060123
- ISSN
- 1361-6560
- DOI
- 10.1088/0031-9155/57/21/7191
- language
- English
- LU publication?
- yes
- id
- 95b03936-13f2-4774-85fb-ffaa24558c9c (old id 3256372)
- date added to LUP
- 2016-04-01 10:51:38
- date last changed
- 2022-02-10 06:39:15
@article{95b03936-13f2-4774-85fb-ffaa24558c9c,
abstract = {{We report how the three-dimensional structure of subcutaneous injections of soluble insulin can be visualized by x-ray computed tomography using an iodine based contrast agent. The injections investigated are performed ex vivo in porcine adipose tissue. Full tomography scans carried out at a laboratory x-ray source with a total acquisition time of about 1 min yield CT-images with an effective pixel size of 109 x 109 mu m(2). The depots are segmented using a modified Chan-Vese algorithm and we are able to observe differences in the shape of the injection depot and the position of the depot in the skin among equally performed injections. To overcome the beam hardening artefacts, which affect the quantitative prediction of the volume injected, we additionally present results concerning the visualization of two injections using synchrotron radiation. The spatial concentration distribution of iodine is calculated to show the dilution of the insulin drug inside the depot. Characterisation of the shape of the depot and the spatial concentration profile of the injected fluid is important knowledge when improving the clinical formulation of an insulin drug, the performance of injection devices and when predicting the effect of the drug through biomedical simulations.}},
author = {{Thomsen, M. and Poulsen, M. and Bech, Martin and Velroyen, A. and Herzen, J. and Beckmann, F. and Feidenhans'l, R. and Pfeiffer, F.}},
issn = {{1361-6560}},
language = {{eng}},
number = {{21}},
pages = {{7191--7203}},
publisher = {{IOP Publishing}},
series = {{Physics in Medicine and Biology}},
title = {{Visualization of subcutaneous insulin injections by x-ray computed tomography}},
url = {{http://dx.doi.org/10.1088/0031-9155/57/21/7191}},
doi = {{10.1088/0031-9155/57/21/7191}},
volume = {{57}},
year = {{2012}},
}