How to Define Pathogenicity, Health, and Disease?
Vihinen, Mauno LU
(2017)
In Human Mutation
38(2).
p.129-136
- Abstract
Scientific and clinical communities produce ever increasing amounts of data and details about health and disease. Our ability to understand and utilize this information is limited because of imprecise language and lack of well-defined concepts. This problem involves also the principal concepts of health, disease, and pathogenicity. Here, a systematic model is presented for pathogenicity, as well as for health and disease. It has three components: extent, modulation, and severity, which jointly define the continuum of pathogenicity. The model is population based, and once implemented, it can be used for numerous purposes such as diagnosis, patient stratification, prognosis, finding phenotype–genotype correlations, or explaining adverse... (More)
Scientific and clinical communities produce ever increasing amounts of data and details about health and disease. Our ability to understand and utilize this information is limited because of imprecise language and lack of well-defined concepts. This problem involves also the principal concepts of health, disease, and pathogenicity. Here, a systematic model is presented for pathogenicity, as well as for health and disease. It has three components: extent, modulation, and severity, which jointly define the continuum of pathogenicity. The model is population based, and once implemented, it can be used for numerous purposes such as diagnosis, patient stratification, prognosis, finding phenotype–genotype correlations, or explaining adverse drug reactions. The new model has several benefits including health economy by allowing evidence-based personalized/precision medicine.
(Less)
- author
- Vihinen, Mauno
LU
- organization
- publishing date
- 2017-02-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- disease, disease extent, disease modulation, disease severity, health, individual variability, pathogenicity, pathogenicity model, pathogenicity zone
- in
- Human Mutation
- volume
- 38
- issue
- 2
- pages
- 8 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85008257158
- pmid:27862583
- wos:000393687800001
- ISSN
- 1059-7794
- DOI
- 10.1002/humu.23144
- language
- English
- LU publication?
- yes
- id
- 95dffb6f-17d1-469b-bb1e-81803f2b936c
- date added to LUP
- 2017-01-19 11:29:53
- date last changed
- 2024-04-05 14:57:28
@article{95dffb6f-17d1-469b-bb1e-81803f2b936c,
abstract = {{<p>Scientific and clinical communities produce ever increasing amounts of data and details about health and disease. Our ability to understand and utilize this information is limited because of imprecise language and lack of well-defined concepts. This problem involves also the principal concepts of health, disease, and pathogenicity. Here, a systematic model is presented for pathogenicity, as well as for health and disease. It has three components: extent, modulation, and severity, which jointly define the continuum of pathogenicity. The model is population based, and once implemented, it can be used for numerous purposes such as diagnosis, patient stratification, prognosis, finding phenotype–genotype correlations, or explaining adverse drug reactions. The new model has several benefits including health economy by allowing evidence-based personalized/precision medicine.</p>}},
author = {{Vihinen, Mauno}},
issn = {{1059-7794}},
keywords = {{disease; disease extent; disease modulation; disease severity; health; individual variability; pathogenicity; pathogenicity model; pathogenicity zone}},
language = {{eng}},
month = {{02}},
number = {{2}},
pages = {{129--136}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Human Mutation}},
title = {{How to Define Pathogenicity, Health, and Disease?}},
url = {{https://lup.lub.lu.se/search/files/31009973/20022959.pdf}},
doi = {{10.1002/humu.23144}},
volume = {{38}},
year = {{2017}},
}