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Rate of over-diagnosis of breast cancer 15 years after end of Malmö mammographic screening trial: follow-up study.

Zackrisson, Sophia LU ; Andersson, Ingvar LU ; Janzon, Lars LU ; Manjer, Jonas LU and Garne, Jens Peter (2006) In BMJ (Clinical Research Edition) 332(7543). p.689-691
Abstract
Objective To evaluate the rate of over-diagnosis of breast cancer 15 years after the end of the Malmo mammographic screening trial. Design Follow-up Study. Setting Malmo, Sweden. Subjects 42 283 women aged 45-69 years at randomisation. Interventions Screening for breast cancer with mammography or not (controls). Screening was offered at end of randomisation design to both groups aged 45-54 at randomisation but not to groups aged 55-69 at randomisation. Main outcome measures Rate of over-diagnosis of breast cancer (in situ and invasive), calculated as incidence in the invited and control groups, during period of randomised design (period 1), during period randomised design ended (period 2), and at end of follow-up. Results In women aged... (More)
Objective To evaluate the rate of over-diagnosis of breast cancer 15 years after the end of the Malmo mammographic screening trial. Design Follow-up Study. Setting Malmo, Sweden. Subjects 42 283 women aged 45-69 years at randomisation. Interventions Screening for breast cancer with mammography or not (controls). Screening was offered at end of randomisation design to both groups aged 45-54 at randomisation but not to groups aged 55-69 at randomisation. Main outcome measures Rate of over-diagnosis of breast cancer (in situ and invasive), calculated as incidence in the invited and control groups, during period of randomised design (period 1), during period randomised design ended (period 2), and at end of follow-up. Results In women aged 55-69 years at randomisation the relative rates of over-diagnosis of breast cancer (95% confidence intervals) were 1.32 (1.14 to 1.53) for period 1, 0.92 (0.79 to 1.06) for period 2, and 1.10 (0.99 to 1.22) at the end of follow-up. Conclusion Conclusions on over-diagnosis of breast cancer in the Malmo mammographic screening trial can be drawn mainly in women aged 55-69 years at randomisation whose control groups were never screened. Fifteen years after die trial ended the rate of over-diagnosis of breast cancer was 10% in this age group. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMJ (Clinical Research Edition)
volume
332
issue
7543
pages
689 - 691
publisher
British Medical Association
external identifiers
  • wos:000236443300015
  • pmid:16517548
  • scopus:33645513485
ISSN
0959-8138
DOI
10.1136/bmj.38764.572569.7C
language
English
LU publication?
yes
id
9613ecd8-2b07-423b-8b0d-7bb3d515b692 (old id 154797)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16517548&dopt=Abstract
date added to LUP
2007-07-30 13:26:43
date last changed
2019-09-17 03:15:26
@article{9613ecd8-2b07-423b-8b0d-7bb3d515b692,
  abstract     = {Objective To evaluate the rate of over-diagnosis of breast cancer 15 years after the end of the Malmo mammographic screening trial. Design Follow-up Study. Setting Malmo, Sweden. Subjects 42 283 women aged 45-69 years at randomisation. Interventions Screening for breast cancer with mammography or not (controls). Screening was offered at end of randomisation design to both groups aged 45-54 at randomisation but not to groups aged 55-69 at randomisation. Main outcome measures Rate of over-diagnosis of breast cancer (in situ and invasive), calculated as incidence in the invited and control groups, during period of randomised design (period 1), during period randomised design ended (period 2), and at end of follow-up. Results In women aged 55-69 years at randomisation the relative rates of over-diagnosis of breast cancer (95% confidence intervals) were 1.32 (1.14 to 1.53) for period 1, 0.92 (0.79 to 1.06) for period 2, and 1.10 (0.99 to 1.22) at the end of follow-up. Conclusion Conclusions on over-diagnosis of breast cancer in the Malmo mammographic screening trial can be drawn mainly in women aged 55-69 years at randomisation whose control groups were never screened. Fifteen years after die trial ended the rate of over-diagnosis of breast cancer was 10% in this age group.},
  author       = {Zackrisson, Sophia and Andersson, Ingvar and Janzon, Lars and Manjer, Jonas and Garne, Jens Peter},
  issn         = {0959-8138},
  language     = {eng},
  number       = {7543},
  pages        = {689--691},
  publisher    = {British Medical Association},
  series       = {BMJ (Clinical Research Edition)},
  title        = {Rate of over-diagnosis of breast cancer 15 years after end of Malmö mammographic screening trial: follow-up study.},
  url          = {http://dx.doi.org/10.1136/bmj.38764.572569.7C},
  volume       = {332},
  year         = {2006},
}