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Insights into the changes in the proteome of Alzheimer disease elucidated by a meta-analysis

Haytural, Hazal ; Benfeitas, Rui ; Schedin-Weiss, Sophia ; Bereczki, Erika ; Rezeli, Melinda LU orcid ; Unwin, Richard D. ; Wang, Xusheng ; Dammer, Eric B. ; Johnson, Erik C.B. and Seyfried, Nicholas T. , et al. (2021) In Scientific Data 8(1).
Abstract

Mass spectrometry (MS)-based proteomics is a powerful tool to explore pathogenic changes of a disease in an unbiased manner and has been used extensively in Alzheimer disease (AD) research. Here, by performing a meta-analysis of high-quality proteomic studies, we address which pathological changes are observed consistently and therefore most likely are of great importance for AD pathogenesis. We retrieved datasets, comprising a total of 21,588 distinct proteins identified across 857 postmortem human samples, from ten studies using labeled or label-free MS approaches. Our meta-analysis findings showed significant alterations of 757 and 1,195 proteins in AD in the labeled and label-free datasets, respectively. Only 33 proteins, some of... (More)

Mass spectrometry (MS)-based proteomics is a powerful tool to explore pathogenic changes of a disease in an unbiased manner and has been used extensively in Alzheimer disease (AD) research. Here, by performing a meta-analysis of high-quality proteomic studies, we address which pathological changes are observed consistently and therefore most likely are of great importance for AD pathogenesis. We retrieved datasets, comprising a total of 21,588 distinct proteins identified across 857 postmortem human samples, from ten studies using labeled or label-free MS approaches. Our meta-analysis findings showed significant alterations of 757 and 1,195 proteins in AD in the labeled and label-free datasets, respectively. Only 33 proteins, some of which were associated with synaptic signaling, had the same directional change across the individual studies. However, despite alterations in individual proteins being different between the labeled and the label-free datasets, several pathways related to synaptic signaling, oxidative phosphorylation, immune response and extracellular matrix were commonly dysregulated in AD. These pathways represent robust changes in the human AD brain and warrant further investigation.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Data
volume
8
issue
1
article number
312
publisher
Nature Publishing Group
external identifiers
  • scopus:85120913808
  • pmid:34862388
ISSN
2052-4463
DOI
10.1038/s41597-021-01090-8
language
English
LU publication?
yes
id
96283117-09a7-4603-ab95-6b326bdbed69
date added to LUP
2022-01-27 12:51:33
date last changed
2024-05-04 20:48:54
@article{96283117-09a7-4603-ab95-6b326bdbed69,
  abstract     = {{<p>Mass spectrometry (MS)-based proteomics is a powerful tool to explore pathogenic changes of a disease in an unbiased manner and has been used extensively in Alzheimer disease (AD) research. Here, by performing a meta-analysis of high-quality proteomic studies, we address which pathological changes are observed consistently and therefore most likely are of great importance for AD pathogenesis. We retrieved datasets, comprising a total of 21,588 distinct proteins identified across 857 postmortem human samples, from ten studies using labeled or label-free MS approaches. Our meta-analysis findings showed significant alterations of 757 and 1,195 proteins in AD in the labeled and label-free datasets, respectively. Only 33 proteins, some of which were associated with synaptic signaling, had the same directional change across the individual studies. However, despite alterations in individual proteins being different between the labeled and the label-free datasets, several pathways related to synaptic signaling, oxidative phosphorylation, immune response and extracellular matrix were commonly dysregulated in AD. These pathways represent robust changes in the human AD brain and warrant further investigation.</p>}},
  author       = {{Haytural, Hazal and Benfeitas, Rui and Schedin-Weiss, Sophia and Bereczki, Erika and Rezeli, Melinda and Unwin, Richard D. and Wang, Xusheng and Dammer, Eric B. and Johnson, Erik C.B. and Seyfried, Nicholas T. and Winblad, Bengt and Tijms, Betty M. and Visser, Pieter Jelle and Frykman, Susanne and Tjernberg, Lars O.}},
  issn         = {{2052-4463}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Data}},
  title        = {{Insights into the changes in the proteome of Alzheimer disease elucidated by a meta-analysis}},
  url          = {{http://dx.doi.org/10.1038/s41597-021-01090-8}},
  doi          = {{10.1038/s41597-021-01090-8}},
  volume       = {{8}},
  year         = {{2021}},
}