An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

Mestdagh, P.; Fredlund, Erik; Pattyn, F.; Rihani, A.; Van Maerken, T.; Vermeulen, J.; Kumps, C.; Menten, B.; De Preter, K.; Schramm, A.; Schulte, J.; Noguera, R.; Schleiermacher, G.; Janoueix-Lerosey, I.; Laureys, G.; Powel, R.; Nittner, D.; Marine, J-C; Ringnér, Markus; Speleman, F.; Vandesompele, J.

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

Mark

Mestdagh, P. ; Fredlund, Erik ^LU ; Pattyn, F. ; Rihani, A. ; Van Maerken, T. ; Vermeulen, J. ; Kumps, C. ; Menten, B. ; De Preter, K. and Schramm, A. , et al. (2010) In Oncogene 29(24). p.3583-3592

Abstract: Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the expression and putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression pro. ling revealed correlations between specific T-UCR expression levels and important clinicogenetic parameters such as MYCN amplification status. A functional genomics approach based on the integration of multi-level transcriptome data was adapted to gain insights into T-UCR functions. Assignments of T-UCRs to cellular processes such as TP53 response, differentiation and proliferation were verified using various cellular... (More); Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the expression and putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression pro. ling revealed correlations between specific T-UCR expression levels and important clinicogenetic parameters such as MYCN amplification status. A functional genomics approach based on the integration of multi-level transcriptome data was adapted to gain insights into T-UCR functions. Assignments of T-UCRs to cellular processes such as TP53 response, differentiation and proliferation were verified using various cellular model systems. For the first time, our results de. ne a T-UCR expression landscape in neuroblastoma and suggest widespread T-UCR involvement in diverse cellular processes that are deregulated in the process of tumourigenesis. Oncogene (2010) 29, 3583-3592; doi:10.1038/onc.2010.106; published online 12 April 2010 (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/1630286

author

Mestdagh, P. ; Fredlund, Erik ^LU ; Pattyn, F. ; Rihani, A. ; Van Maerken, T. ; Vermeulen, J. ; Kumps, C. ; Menten, B. ; De Preter, K. and Schramm, A. , et al. (More)

Mestdagh, P. ; Fredlund, Erik ^LU ; Pattyn, F. ; Rihani, A. ; Van Maerken, T. ; Vermeulen, J. ; Kumps, C. ; Menten, B. ; De Preter, K. ; Schramm, A. ; Schulte, J. ; Noguera, R. ; Schleiermacher, G. ; Janoueix-Lerosey, I. ; Laureys, G. ; Powel, R. ; Nittner, D. ; Marine, J-C ; Ringnér, Markus ^LU

; Speleman, F. and Vandesompele, J. (Less)

organization

Breastcancer-genetics

publishing date

2010

type

Contribution to journal

publication status

published

subject

Cancer and Oncology

keywords

non-coding RNA, neuroblastoma, T-UCR

in

Oncogene

volume

29

issue

24

pages

3583 - 3592

publisher

Nature Publishing Group

external identifiers

wos:000278835400013
scopus:77953808788
pmid:20383195

ISSN

1476-5594

DOI

10.1038/onc.2010.106

language

English

LU publication?

yes

id

965ae2c6-2556-4dc2-86e7-f99a715ccb6f (old id 1630286)

date added to LUP

2016-04-01 11:10:05

date last changed

2022-04-28 07:44:05

@article{965ae2c6-2556-4dc2-86e7-f99a715ccb6f,
  abstract     = {{Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the expression and putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression pro. ling revealed correlations between specific T-UCR expression levels and important clinicogenetic parameters such as MYCN amplification status. A functional genomics approach based on the integration of multi-level transcriptome data was adapted to gain insights into T-UCR functions. Assignments of T-UCRs to cellular processes such as TP53 response, differentiation and proliferation were verified using various cellular model systems. For the first time, our results de. ne a T-UCR expression landscape in neuroblastoma and suggest widespread T-UCR involvement in diverse cellular processes that are deregulated in the process of tumourigenesis. Oncogene (2010) 29, 3583-3592; doi:10.1038/onc.2010.106; published online 12 April 2010}},
  author       = {{Mestdagh, P. and Fredlund, Erik and Pattyn, F. and Rihani, A. and Van Maerken, T. and Vermeulen, J. and Kumps, C. and Menten, B. and De Preter, K. and Schramm, A. and Schulte, J. and Noguera, R. and Schleiermacher, G. and Janoueix-Lerosey, I. and Laureys, G. and Powel, R. and Nittner, D. and Marine, J-C and Ringnér, Markus and Speleman, F. and Vandesompele, J.}},
  issn         = {{1476-5594}},
  keywords     = {{non-coding RNA; neuroblastoma; T-UCR}},
  language     = {{eng}},
  number       = {{24}},
  pages        = {{3583--3592}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Oncogene}},
  title        = {{An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours}},
  url          = {{http://dx.doi.org/10.1038/onc.2010.106}},
  doi          = {{10.1038/onc.2010.106}},
  volume       = {{29}},
  year         = {{2010}},
}

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An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours