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Fine-needle aspiration cytology of soft tissue lesions: Diagnostic challenges

Domanski, Henryk LU (2007) In Diagnostic Cytopathology 35(12). p.768-773
Abstract
Clinical and radiographic data provide important information in the evaluation of soft tissue lesions/neoplasms. Morphologic tissue and cytologic examination is considered to be a necessary part of the diagnostic work-up. The standard procedure for obtaining tumor tissue for morphologic evaluation has been incisional (open) or core needle biopsy. An increasing use of minimally invasive diagnostic procedures has resulted in better acceptance of fine-needle aspiration cytology (FNAC) in the diagnosis of soft tissue lesions. This article discusses challenges in FNAC of soft tissue lesions based on the experience at a multidisciplinary referral sarcoma center. Obtaining sufficient specimens from deeply seated small and necrotic/cystic lesions... (More)
Clinical and radiographic data provide important information in the evaluation of soft tissue lesions/neoplasms. Morphologic tissue and cytologic examination is considered to be a necessary part of the diagnostic work-up. The standard procedure for obtaining tumor tissue for morphologic evaluation has been incisional (open) or core needle biopsy. An increasing use of minimally invasive diagnostic procedures has resulted in better acceptance of fine-needle aspiration cytology (FNAC) in the diagnosis of soft tissue lesions. This article discusses challenges in FNAC of soft tissue lesions based on the experience at a multidisciplinary referral sarcoma center. Obtaining sufficient specimens from deeply seated small and necrotic/cystic lesions is technically a potential pitfall and misdiagnosis of cells from reactive zones surrounding the tumor as well as the correct evaluation of spindle cell lesions, rare soft tissue neoplasms, and "new entities" lacking reproducible cytological criteria are other important challenges in FNAC of sofa tissues. The succes, successful cytological evaluation of soft tissue lesions requires the application of strict, reproducible morphological criteria in the context of the clinical findings as well as ancillary techniques. The minimal criteria for diagnostic intervention in various clinical settings and the relative advantages and disadvantages of FNAC must be understood. FNAC (of soft tissue lesions is facilitated when limited to specialized orthopedic-oncologic centers with a well- integrated multidisciplinary team and experience in the evaluation and therapy of soft tissue lesions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biopsy, sarcoma, ancillary techniques, fine-needle aspiration, cytology, soft tissue
in
Diagnostic Cytopathology
volume
35
issue
12
pages
768 - 773
publisher
John Wiley & Sons
external identifiers
  • wos:000251561900005
  • scopus:37049017086
ISSN
8755-1039
DOI
10.1002/dc.20765
language
English
LU publication?
yes
id
dfd8d05b-5ccf-4663-914b-06dc74eafe2c (old id 966134)
date added to LUP
2008-01-29 14:37:03
date last changed
2017-11-05 03:27:43
@article{dfd8d05b-5ccf-4663-914b-06dc74eafe2c,
  abstract     = {Clinical and radiographic data provide important information in the evaluation of soft tissue lesions/neoplasms. Morphologic tissue and cytologic examination is considered to be a necessary part of the diagnostic work-up. The standard procedure for obtaining tumor tissue for morphologic evaluation has been incisional (open) or core needle biopsy. An increasing use of minimally invasive diagnostic procedures has resulted in better acceptance of fine-needle aspiration cytology (FNAC) in the diagnosis of soft tissue lesions. This article discusses challenges in FNAC of soft tissue lesions based on the experience at a multidisciplinary referral sarcoma center. Obtaining sufficient specimens from deeply seated small and necrotic/cystic lesions is technically a potential pitfall and misdiagnosis of cells from reactive zones surrounding the tumor as well as the correct evaluation of spindle cell lesions, rare soft tissue neoplasms, and "new entities" lacking reproducible cytological criteria are other important challenges in FNAC of sofa tissues. The succes, successful cytological evaluation of soft tissue lesions requires the application of strict, reproducible morphological criteria in the context of the clinical findings as well as ancillary techniques. The minimal criteria for diagnostic intervention in various clinical settings and the relative advantages and disadvantages of FNAC must be understood. FNAC (of soft tissue lesions is facilitated when limited to specialized orthopedic-oncologic centers with a well- integrated multidisciplinary team and experience in the evaluation and therapy of soft tissue lesions.},
  author       = {Domanski, Henryk},
  issn         = {8755-1039},
  keyword      = {biopsy,sarcoma,ancillary techniques,fine-needle aspiration,cytology,soft tissue},
  language     = {eng},
  number       = {12},
  pages        = {768--773},
  publisher    = {John Wiley & Sons},
  series       = {Diagnostic Cytopathology},
  title        = {Fine-needle aspiration cytology of soft tissue lesions: Diagnostic challenges},
  url          = {http://dx.doi.org/10.1002/dc.20765},
  volume       = {35},
  year         = {2007},
}