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Changing pattern in the prescription of biological treatment in rheumatoid arthritis. A 7-year follow-up of 1839 patients in southern Sweden

Soderlin, M. K. and Geborek, Pierre LU (2008) In Annals of the Rheumatic Diseases 67(1). p.37-42
Abstract
Objective: To study prescription patterns of biological treatment in rheumatoid arthritis ( RA) patients in southern Sweden, a region with no formal or economic restrictions for the use of biological treatment in rheumatological diseases. Specifically, we studied conformity with the national Swedish guidelines for biologics in RA. Methods: Rheumatologists in southern Sweden contribute to a voluntary register on the use of biologics in treating arthritis patients ( the South Swedish Arthritis Treatment Group ( SSATG)). This register covers >90% of all the prescriptions of biologics for arthritis patients in the region. The treatment of 1839 patients ( 2704 treatment occasions) was recorded in the SSATG register during 1999-2006. Baseline... (More)
Objective: To study prescription patterns of biological treatment in rheumatoid arthritis ( RA) patients in southern Sweden, a region with no formal or economic restrictions for the use of biological treatment in rheumatological diseases. Specifically, we studied conformity with the national Swedish guidelines for biologics in RA. Methods: Rheumatologists in southern Sweden contribute to a voluntary register on the use of biologics in treating arthritis patients ( the South Swedish Arthritis Treatment Group ( SSATG)). This register covers >90% of all the prescriptions of biologics for arthritis patients in the region. The treatment of 1839 patients ( 2704 treatment occasions) was recorded in the SSATG register during 1999-2006. Baseline characteristics were analysed. Results: Baseline Health Assessment Questionnaire ( HAQ) scores and Disease Activity Scores ( DASs) decreased significantly between 1999 and 2006, but disease activity remained high in RA patients. RA patients were treated with biologics earlier, but only 16% of the patients received biologics within 2 years of disease onset in 2006. The percentage of RA patients who were prescribed biologics after only one previous non-biological DMARD ( disease-modifying anti-inflammatory rheumatic drug) was 27% in 2006. Thirty-five per cent of all RA patients changed from one biological treatment to another. Conclusions: Baseline DASs in RA patients remained high at the start of biological treatment. The national Swedish guidelines for the prescription of biologics in RA were followed. More patients with early RA were treated with biologics. The proportion of RA patients changing from one biological drug to another increased. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of the Rheumatic Diseases
volume
67
issue
1
pages
37 - 42
publisher
British Medical Association
external identifiers
  • wos:000251615600007
  • scopus:37749021991
ISSN
1468-2060
DOI
10.1136/ard.2007.070714
language
English
LU publication?
yes
id
9567766a-1806-4b94-905a-d90ba0e9a416 (old id 966202)
date added to LUP
2008-08-08 13:56:38
date last changed
2017-05-07 03:46:46
@article{9567766a-1806-4b94-905a-d90ba0e9a416,
  abstract     = {Objective: To study prescription patterns of biological treatment in rheumatoid arthritis ( RA) patients in southern Sweden, a region with no formal or economic restrictions for the use of biological treatment in rheumatological diseases. Specifically, we studied conformity with the national Swedish guidelines for biologics in RA. Methods: Rheumatologists in southern Sweden contribute to a voluntary register on the use of biologics in treating arthritis patients ( the South Swedish Arthritis Treatment Group ( SSATG)). This register covers >90% of all the prescriptions of biologics for arthritis patients in the region. The treatment of 1839 patients ( 2704 treatment occasions) was recorded in the SSATG register during 1999-2006. Baseline characteristics were analysed. Results: Baseline Health Assessment Questionnaire ( HAQ) scores and Disease Activity Scores ( DASs) decreased significantly between 1999 and 2006, but disease activity remained high in RA patients. RA patients were treated with biologics earlier, but only 16% of the patients received biologics within 2 years of disease onset in 2006. The percentage of RA patients who were prescribed biologics after only one previous non-biological DMARD ( disease-modifying anti-inflammatory rheumatic drug) was 27% in 2006. Thirty-five per cent of all RA patients changed from one biological treatment to another. Conclusions: Baseline DASs in RA patients remained high at the start of biological treatment. The national Swedish guidelines for the prescription of biologics in RA were followed. More patients with early RA were treated with biologics. The proportion of RA patients changing from one biological drug to another increased.},
  author       = {Soderlin, M. K. and Geborek, Pierre},
  issn         = {1468-2060},
  language     = {eng},
  number       = {1},
  pages        = {37--42},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Changing pattern in the prescription of biological treatment in rheumatoid arthritis. A 7-year follow-up of 1839 patients in southern Sweden},
  url          = {http://dx.doi.org/10.1136/ard.2007.070714},
  volume       = {67},
  year         = {2008},
}