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Five-year follow-up during antipsychotic treatment: efficacy, safety, functional and social outcome

Lindstrom, E.; Eberhard, Jonas LU and Levander, Sten LU (2007) In Acta Psychiatrica Scandinavica 116. p.5-16
Abstract
Objective: Explore the long-term course of schizophrenia and related disorders. Method: Naturalistic study of 225 patients initially treated with risperidone (monotherapy or in combination with other psychotropic drugs) over 5 years. Results: Stable symptomatology and side effects were observed. Clinician GAF scores were 55-61, but patients' self-ratings were higher. Clinician and patient CGI scores were at the same level. Annual in-patient days decreased but days in sheltered accommodations increased still more. Only 12% of the patients studied or worked fulltime. One in four had no social contacts except with staff. Eight patients died during the 5 years. Conclusion: The findings underline the chronicity and seriousness of psychotic... (More)
Objective: Explore the long-term course of schizophrenia and related disorders. Method: Naturalistic study of 225 patients initially treated with risperidone (monotherapy or in combination with other psychotropic drugs) over 5 years. Results: Stable symptomatology and side effects were observed. Clinician GAF scores were 55-61, but patients' self-ratings were higher. Clinician and patient CGI scores were at the same level. Annual in-patient days decreased but days in sheltered accommodations increased still more. Only 12% of the patients studied or worked fulltime. One in four had no social contacts except with staff. Eight patients died during the 5 years. Conclusion: The findings underline the chronicity and seriousness of psychotic disorders in terms of social outcome and, indirectly, the low quality of life of this group of persons. Patients were generally well aware of their illness and able to sort out symptoms from drug side effects. This opens for more active involvement of patients in monitoring their own treatment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
schizophrenia, antipsychotics, longitudinal, risperidone
in
Acta Psychiatrica Scandinavica
volume
116
pages
5 - 16
publisher
Wiley-Blackwell
external identifiers
  • wos:000251503800002
  • scopus:33847626524
ISSN
1600-0447
DOI
10.1111/j.1600-0447.2007.01083.x
language
English
LU publication?
yes
id
86ea4d19-04f4-4081-bfb2-aa2a12edfde5 (old id 966441)
date added to LUP
2008-01-30 09:04:53
date last changed
2017-08-09 14:34:02
@article{86ea4d19-04f4-4081-bfb2-aa2a12edfde5,
  abstract     = {Objective: Explore the long-term course of schizophrenia and related disorders. Method: Naturalistic study of 225 patients initially treated with risperidone (monotherapy or in combination with other psychotropic drugs) over 5 years. Results: Stable symptomatology and side effects were observed. Clinician GAF scores were 55-61, but patients' self-ratings were higher. Clinician and patient CGI scores were at the same level. Annual in-patient days decreased but days in sheltered accommodations increased still more. Only 12% of the patients studied or worked fulltime. One in four had no social contacts except with staff. Eight patients died during the 5 years. Conclusion: The findings underline the chronicity and seriousness of psychotic disorders in terms of social outcome and, indirectly, the low quality of life of this group of persons. Patients were generally well aware of their illness and able to sort out symptoms from drug side effects. This opens for more active involvement of patients in monitoring their own treatment.},
  author       = {Lindstrom, E. and Eberhard, Jonas and Levander, Sten},
  issn         = {1600-0447},
  keyword      = {schizophrenia,antipsychotics,longitudinal,risperidone},
  language     = {eng},
  pages        = {5--16},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Psychiatrica Scandinavica},
  title        = {Five-year follow-up during antipsychotic treatment: efficacy, safety, functional and social outcome},
  url          = {http://dx.doi.org/10.1111/j.1600-0447.2007.01083.x},
  volume       = {116},
  year         = {2007},
}