17 beta-estradiol expands IgA-Producing b cells in mice deficient for the mu chain
(2008) In Scandinavian Journal of Immunology 67(1). p.12-17- Abstract
- Oestrogen is not only a sex hormone but also an important regulator of the immune system. Expression of the heavy chain of IgM (mu) is essential for B-cell differentiation. However, a small number of IgA-positive B cells can be found in mice lacking the mu chain (mu MT-/-). The aim of this study was to investigate the effects of oestrogen on this alternative B-cell pathway in mu MT-/- mice. Our results clearly demonstrate that oestrogen increases the frequency of IgA-producing B cells in mu MT-/- mice in both bone marrow and spleen cells. We also show that mature IgM-producing B cells are not required for oestrogen-mediated suppression of granulocyte-mediated inflammation or thymic involution. In conclusion, we demonstrate that 17... (More)
- Oestrogen is not only a sex hormone but also an important regulator of the immune system. Expression of the heavy chain of IgM (mu) is essential for B-cell differentiation. However, a small number of IgA-positive B cells can be found in mice lacking the mu chain (mu MT-/-). The aim of this study was to investigate the effects of oestrogen on this alternative B-cell pathway in mu MT-/- mice. Our results clearly demonstrate that oestrogen increases the frequency of IgA-producing B cells in mu MT-/- mice in both bone marrow and spleen cells. We also show that mature IgM-producing B cells are not required for oestrogen-mediated suppression of granulocyte-mediated inflammation or thymic involution. In conclusion, we demonstrate that 17 beta-estradiol benzoate increases the frequency of IgA-producing B cells in mu MT-/- mice, suggesting that oestrogen can influence the alternative B-cell pathway found in mu MT-/- mice. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/966473
- author
- Lagerquist, M. K. ; Erlandsson, M. C. ; Islander, U. ; Svensson, L. ; Holmdahl, Rikard LU and Carlsten, H.
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Immunology
- volume
- 67
- issue
- 1
- pages
- 12 - 17
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000251329700002
- scopus:36749043215
- pmid:18021189
- ISSN
- 1365-3083
- DOI
- 10.1111/j.1365-3083.2007.02027.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
- id
- 0630c844-4980-4b79-aec1-f2d92a0358d4 (old id 966473)
- date added to LUP
- 2016-04-01 12:52:55
- date last changed
- 2022-01-27 08:07:03
@article{0630c844-4980-4b79-aec1-f2d92a0358d4,
abstract = {{Oestrogen is not only a sex hormone but also an important regulator of the immune system. Expression of the heavy chain of IgM (mu) is essential for B-cell differentiation. However, a small number of IgA-positive B cells can be found in mice lacking the mu chain (mu MT-/-). The aim of this study was to investigate the effects of oestrogen on this alternative B-cell pathway in mu MT-/- mice. Our results clearly demonstrate that oestrogen increases the frequency of IgA-producing B cells in mu MT-/- mice in both bone marrow and spleen cells. We also show that mature IgM-producing B cells are not required for oestrogen-mediated suppression of granulocyte-mediated inflammation or thymic involution. In conclusion, we demonstrate that 17 beta-estradiol benzoate increases the frequency of IgA-producing B cells in mu MT-/- mice, suggesting that oestrogen can influence the alternative B-cell pathway found in mu MT-/- mice.}},
author = {{Lagerquist, M. K. and Erlandsson, M. C. and Islander, U. and Svensson, L. and Holmdahl, Rikard and Carlsten, H.}},
issn = {{1365-3083}},
language = {{eng}},
number = {{1}},
pages = {{12--17}},
publisher = {{Wiley-Blackwell}},
series = {{Scandinavian Journal of Immunology}},
title = {{17 beta-estradiol expands IgA-Producing b cells in mice deficient for the mu chain}},
url = {{http://dx.doi.org/10.1111/j.1365-3083.2007.02027.x}},
doi = {{10.1111/j.1365-3083.2007.02027.x}},
volume = {{67}},
year = {{2008}},
}