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17 beta-estradiol expands IgA-Producing b cells in mice deficient for the mu chain

Lagerquist, M. K.; Erlandsson, M. C.; Islander, U.; Svensson, L.; Holmdahl, Rikard LU and Carlsten, H. (2008) In Scandinavian Journal of Immunology 67(1). p.12-17
Abstract
Oestrogen is not only a sex hormone but also an important regulator of the immune system. Expression of the heavy chain of IgM (mu) is essential for B-cell differentiation. However, a small number of IgA-positive B cells can be found in mice lacking the mu chain (mu MT-/-). The aim of this study was to investigate the effects of oestrogen on this alternative B-cell pathway in mu MT-/- mice. Our results clearly demonstrate that oestrogen increases the frequency of IgA-producing B cells in mu MT-/- mice in both bone marrow and spleen cells. We also show that mature IgM-producing B cells are not required for oestrogen-mediated suppression of granulocyte-mediated inflammation or thymic involution. In conclusion, we demonstrate that 17... (More)
Oestrogen is not only a sex hormone but also an important regulator of the immune system. Expression of the heavy chain of IgM (mu) is essential for B-cell differentiation. However, a small number of IgA-positive B cells can be found in mice lacking the mu chain (mu MT-/-). The aim of this study was to investigate the effects of oestrogen on this alternative B-cell pathway in mu MT-/- mice. Our results clearly demonstrate that oestrogen increases the frequency of IgA-producing B cells in mu MT-/- mice in both bone marrow and spleen cells. We also show that mature IgM-producing B cells are not required for oestrogen-mediated suppression of granulocyte-mediated inflammation or thymic involution. In conclusion, we demonstrate that 17 beta-estradiol benzoate increases the frequency of IgA-producing B cells in mu MT-/- mice, suggesting that oestrogen can influence the alternative B-cell pathway found in mu MT-/- mice. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Immunology
volume
67
issue
1
pages
12 - 17
publisher
Wiley-Blackwell
external identifiers
  • wos:000251329700002
  • scopus:36749043215
ISSN
1365-3083
DOI
10.1111/j.1365-3083.2007.02027.x
language
English
LU publication?
yes
id
0630c844-4980-4b79-aec1-f2d92a0358d4 (old id 966473)
date added to LUP
2009-07-08 14:21:56
date last changed
2017-01-01 05:20:40
@article{0630c844-4980-4b79-aec1-f2d92a0358d4,
  abstract     = {Oestrogen is not only a sex hormone but also an important regulator of the immune system. Expression of the heavy chain of IgM (mu) is essential for B-cell differentiation. However, a small number of IgA-positive B cells can be found in mice lacking the mu chain (mu MT-/-). The aim of this study was to investigate the effects of oestrogen on this alternative B-cell pathway in mu MT-/- mice. Our results clearly demonstrate that oestrogen increases the frequency of IgA-producing B cells in mu MT-/- mice in both bone marrow and spleen cells. We also show that mature IgM-producing B cells are not required for oestrogen-mediated suppression of granulocyte-mediated inflammation or thymic involution. In conclusion, we demonstrate that 17 beta-estradiol benzoate increases the frequency of IgA-producing B cells in mu MT-/- mice, suggesting that oestrogen can influence the alternative B-cell pathway found in mu MT-/- mice.},
  author       = {Lagerquist, M. K. and Erlandsson, M. C. and Islander, U. and Svensson, L. and Holmdahl, Rikard and Carlsten, H.},
  issn         = {1365-3083},
  language     = {eng},
  number       = {1},
  pages        = {12--17},
  publisher    = {Wiley-Blackwell},
  series       = {Scandinavian Journal of Immunology},
  title        = {17 beta-estradiol expands IgA-Producing b cells in mice deficient for the mu chain},
  url          = {http://dx.doi.org/10.1111/j.1365-3083.2007.02027.x},
  volume       = {67},
  year         = {2008},
}