Differential modulation of inflammatory pain by a selective estrogen receptor beta agonist
Gardell, Luis R. ; Hyldtoft, Lene ; Del Tredici, Andria L. ; Andersen, Carsten B. ; Fairbairn, Luke C. ; Lund, Birgitte W. ; Gustafsson, Magnus ; Brann, Mark R. ; Olsson, Roger LU
and Piu, Fabrice
(2008)
In European Journal of Pharmacology
592(1-3).
p.158-159
- Abstract
To understand the contribution of the estrogen receptor beta, the potent and selective agonist ERb-131 was evaluated in animal models of inflammatory pain. In paradigms of acute and persistent inflammatory pain, ERb-131 did not alleviate the nociception induced by either carrageenan or formalin. However, in the chronic complete Freund's adjuvant model, ERb-131 resolved both inflammatory and hyperalgesic components. Thus, ERb-131 is sufficient to alleviate chronic but not acute inflammatory pain states.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/967d3a0f-eeca-488d-877e-c37a485c89c2
- author
- Gardell, Luis R.
; Hyldtoft, Lene
; Del Tredici, Andria L.
; Andersen, Carsten B.
; Fairbairn, Luke C.
; Lund, Birgitte W.
; Gustafsson, Magnus
; Brann, Mark R.
; Olsson, Roger
LU
and Piu, Fabrice
- publishing date
- 2008-09-11
- type
- Contribution to journal
- publication status
- published
- keywords
- Estrogen receptor beta, Inflammation, Pain
- in
- European Journal of Pharmacology
- volume
- 592
- issue
- 1-3
- pages
- 2 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:49749149139
- pmid:18644363
- ISSN
- 0014-2999
- DOI
- 10.1016/j.ejphar.2008.06.107
- language
- English
- LU publication?
- no
- id
- 967d3a0f-eeca-488d-877e-c37a485c89c2
- date added to LUP
- 2019-10-02 10:21:45
- date last changed
- 2024-01-01 21:25:42
@article{967d3a0f-eeca-488d-877e-c37a485c89c2,
abstract = {{<p>To understand the contribution of the estrogen receptor beta, the potent and selective agonist ERb-131 was evaluated in animal models of inflammatory pain. In paradigms of acute and persistent inflammatory pain, ERb-131 did not alleviate the nociception induced by either carrageenan or formalin. However, in the chronic complete Freund's adjuvant model, ERb-131 resolved both inflammatory and hyperalgesic components. Thus, ERb-131 is sufficient to alleviate chronic but not acute inflammatory pain states.</p>}},
author = {{Gardell, Luis R. and Hyldtoft, Lene and Del Tredici, Andria L. and Andersen, Carsten B. and Fairbairn, Luke C. and Lund, Birgitte W. and Gustafsson, Magnus and Brann, Mark R. and Olsson, Roger and Piu, Fabrice}},
issn = {{0014-2999}},
keywords = {{Estrogen receptor beta; Inflammation; Pain}},
language = {{eng}},
month = {{09}},
number = {{1-3}},
pages = {{158--159}},
publisher = {{Elsevier}},
series = {{European Journal of Pharmacology}},
title = {{Differential modulation of inflammatory pain by a selective estrogen receptor beta agonist}},
url = {{http://dx.doi.org/10.1016/j.ejphar.2008.06.107}},
doi = {{10.1016/j.ejphar.2008.06.107}},
volume = {{592}},
year = {{2008}},
}