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Differential modulation of inflammatory pain by a selective estrogen receptor beta agonist

Gardell, Luis R. ; Hyldtoft, Lene ; Del Tredici, Andria L. ; Andersen, Carsten B. ; Fairbairn, Luke C. ; Lund, Birgitte W. ; Gustafsson, Magnus ; Brann, Mark R. ; Olsson, Roger LU and Piu, Fabrice (2008) In European Journal of Pharmacology 592(1-3). p.158-159
Abstract

To understand the contribution of the estrogen receptor beta, the potent and selective agonist ERb-131 was evaluated in animal models of inflammatory pain. In paradigms of acute and persistent inflammatory pain, ERb-131 did not alleviate the nociception induced by either carrageenan or formalin. However, in the chronic complete Freund's adjuvant model, ERb-131 resolved both inflammatory and hyperalgesic components. Thus, ERb-131 is sufficient to alleviate chronic but not acute inflammatory pain states.

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author
; ; ; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Estrogen receptor beta, Inflammation, Pain
in
European Journal of Pharmacology
volume
592
issue
1-3
pages
2 pages
publisher
Elsevier
external identifiers
  • pmid:18644363
  • scopus:49749149139
ISSN
0014-2999
DOI
10.1016/j.ejphar.2008.06.107
language
English
LU publication?
no
id
967d3a0f-eeca-488d-877e-c37a485c89c2
date added to LUP
2019-10-02 10:21:45
date last changed
2020-02-12 10:15:39
@misc{967d3a0f-eeca-488d-877e-c37a485c89c2,
  abstract     = {<p>To understand the contribution of the estrogen receptor beta, the potent and selective agonist ERb-131 was evaluated in animal models of inflammatory pain. In paradigms of acute and persistent inflammatory pain, ERb-131 did not alleviate the nociception induced by either carrageenan or formalin. However, in the chronic complete Freund's adjuvant model, ERb-131 resolved both inflammatory and hyperalgesic components. Thus, ERb-131 is sufficient to alleviate chronic but not acute inflammatory pain states.</p>},
  author       = {Gardell, Luis R. and Hyldtoft, Lene and Del Tredici, Andria L. and Andersen, Carsten B. and Fairbairn, Luke C. and Lund, Birgitte W. and Gustafsson, Magnus and Brann, Mark R. and Olsson, Roger and Piu, Fabrice},
  issn         = {0014-2999},
  language     = {eng},
  month        = {09},
  number       = {1-3},
  pages        = {158--159},
  publisher    = {Elsevier},
  series       = {European Journal of Pharmacology},
  title        = {Differential modulation of inflammatory pain by a selective estrogen receptor beta agonist},
  url          = {http://dx.doi.org/10.1016/j.ejphar.2008.06.107},
  doi          = {10.1016/j.ejphar.2008.06.107},
  volume       = {592},
  year         = {2008},
}