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Cystatin C modulates cerebral beta-amyloidosis

Kaeser, Stephan A.; Herzig, Martin C.; Coomaraswamy, Janaky; Kilger, Ellen; Selenica, Maj-Linda; Winkler, David T.; Staufenbiel, Matthias; Levy, Efrat; Grubb, Anders LU and Jucker, Mathias (2007) In Nature Genetics 39(12). p.1437-1439
Abstract
The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Genetics
volume
39
issue
12
pages
1437 - 1439
publisher
Nature Publishing Group
external identifiers
  • wos:000251267400009
  • scopus:36549085086
ISSN
1546-1718
DOI
10.1038/ng.2007.23
language
English
LU publication?
yes
id
321157a5-f3cd-486d-93c6-92ba3f3b66b1 (old id 968576)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18026102
http://www.hih-tuebingen.de/fileadmin/files/Presse/Dokumente/ng.2007.23.pdf
http://www.nature.com/ng/journal/v39/n12/full/ng.2007.23.html
date added to LUP
2008-01-29 16:13:42
date last changed
2017-10-01 04:50:53
@article{321157a5-f3cd-486d-93c6-92ba3f3b66b1,
  abstract     = {The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.},
  author       = {Kaeser, Stephan A. and Herzig, Martin C. and Coomaraswamy, Janaky and Kilger, Ellen and Selenica, Maj-Linda and Winkler, David T. and Staufenbiel, Matthias and Levy, Efrat and Grubb, Anders and Jucker, Mathias},
  issn         = {1546-1718},
  language     = {eng},
  number       = {12},
  pages        = {1437--1439},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Cystatin C modulates cerebral beta-amyloidosis},
  url          = {http://dx.doi.org/10.1038/ng.2007.23},
  volume       = {39},
  year         = {2007},
}