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Risk for schizophrenia in intercountry adoptees: a Danish population-based cohort study

Cantor-Graae, Elizabeth LU and Pedersen, Carsten Bocker (2007) In Journal of Child Psychology and Psychiatry and Allied Disciplines 48(11). p.1053-1060
Abstract
Background: Increasing numbers of intercountry adoptees are reaching adulthood, the age of onset for most serious mental disorders. Little is known about the development of schizophrenia in intercountry adoptees, a group with potentially increased vulnerability. The aim of this study was to investigate the risk of developing schizophrenia in adoptees and in non-adoptees. Methods: Utilising data from the Danish Civil Registration System, we established a population-based cohort of 1.06 million persons resident in Denmark before the age of 15, whose legal mother lived in Denmark at the child's birth. Intercountry adoptees were identified as children born abroad. Record linkage provided information on psychiatric admissions. Results:... (More)
Background: Increasing numbers of intercountry adoptees are reaching adulthood, the age of onset for most serious mental disorders. Little is known about the development of schizophrenia in intercountry adoptees, a group with potentially increased vulnerability. The aim of this study was to investigate the risk of developing schizophrenia in adoptees and in non-adoptees. Methods: Utilising data from the Danish Civil Registration System, we established a population-based cohort of 1.06 million persons resident in Denmark before the age of 15, whose legal mother lived in Denmark at the child's birth. Intercountry adoptees were identified as children born abroad. Record linkage provided information on psychiatric admissions. Results: Intercountry adoptees had an increased relative risk (RR) (RR = 2.90, 95% CI 2.41-3.50) of developing schizophrenia compared to native Danes. The increased risk was independent of age at onset and age at, or region of, adoption, and was not attributable to mental illness in a foster parent, the foster parent's age, or to urbanisation. The foster mother's own biological offspring had also an increased risk of developing schizophrenia (1.92, 95% Cl 1.23-3.02). Conclusions: Young adult intercountry adoptees are at increased risk for schizophrenia. Although the underlying cause is unknown, a complex interplay of factors presumably may be involved, including heredity, adversity prior to adoption, and post-adoption adjustment difficulties during upbringing. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
intercountry adoptees, schizophrenia, age at onset, Denmark, parental, age, urbanisation, siblings, epidemiology
in
Journal of Child Psychology and Psychiatry and Allied Disciplines
volume
48
issue
11
pages
1053 - 1060
publisher
Wiley-Blackwell
external identifiers
  • wos:000251082200002
  • scopus:36049039253
ISSN
1469-7610
DOI
10.1111/j.1469-7610.2007.01788.x
language
English
LU publication?
yes
id
378c15e3-9e3f-4907-bb34-07ed9216e804 (old id 969062)
date added to LUP
2008-01-29 13:56:19
date last changed
2017-05-21 03:37:32
@article{378c15e3-9e3f-4907-bb34-07ed9216e804,
  abstract     = {Background: Increasing numbers of intercountry adoptees are reaching adulthood, the age of onset for most serious mental disorders. Little is known about the development of schizophrenia in intercountry adoptees, a group with potentially increased vulnerability. The aim of this study was to investigate the risk of developing schizophrenia in adoptees and in non-adoptees. Methods: Utilising data from the Danish Civil Registration System, we established a population-based cohort of 1.06 million persons resident in Denmark before the age of 15, whose legal mother lived in Denmark at the child's birth. Intercountry adoptees were identified as children born abroad. Record linkage provided information on psychiatric admissions. Results: Intercountry adoptees had an increased relative risk (RR) (RR = 2.90, 95% CI 2.41-3.50) of developing schizophrenia compared to native Danes. The increased risk was independent of age at onset and age at, or region of, adoption, and was not attributable to mental illness in a foster parent, the foster parent's age, or to urbanisation. The foster mother's own biological offspring had also an increased risk of developing schizophrenia (1.92, 95% Cl 1.23-3.02). Conclusions: Young adult intercountry adoptees are at increased risk for schizophrenia. Although the underlying cause is unknown, a complex interplay of factors presumably may be involved, including heredity, adversity prior to adoption, and post-adoption adjustment difficulties during upbringing.},
  author       = {Cantor-Graae, Elizabeth and Pedersen, Carsten Bocker},
  issn         = {1469-7610},
  keyword      = {intercountry adoptees,schizophrenia,age at onset,Denmark,parental,age,urbanisation,siblings,epidemiology},
  language     = {eng},
  number       = {11},
  pages        = {1053--1060},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Child Psychology and Psychiatry and Allied Disciplines},
  title        = {Risk for schizophrenia in intercountry adoptees: a Danish population-based cohort study},
  url          = {http://dx.doi.org/10.1111/j.1469-7610.2007.01788.x},
  volume       = {48},
  year         = {2007},
}