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Syndecan Heparan Sulfate Proteoglycans: Regulation, Signaling and Impact on Tumor Biology

Maciel Gomes, Angelica; Sinkeviciute, Dovile LU ; Multhaupt, Hinke Arnolda B.; Yoneda, Atsuko and Couchman, John Robert (2016) In Trends in Glycoscience and Glycotechnology 28(163). p.79-90
Abstract
Virtually all animal cells express heparan sulfate proteoglycans on the cell surface and in the extracellular matrix. Syndecans are a major group of transmembrane proteoglycans functioning as receptors that mediate signal transmission from the extracellular microenvironment to the cell. Their heparan sulfate chains, due to their vast structural diversity, interact with a wide array of ligands including potent regulators of adhesion, migration, growth and survival. Frequently, ligands interact with cell surface heparan sulfate in conjunction with high affinity receptors. The consequent signaling can therefore be complex, but it is now known that syndecans are capable of independent signaling. This review is divided in two sections, and will... (More)
Virtually all animal cells express heparan sulfate proteoglycans on the cell surface and in the extracellular matrix. Syndecans are a major group of transmembrane proteoglycans functioning as receptors that mediate signal transmission from the extracellular microenvironment to the cell. Their heparan sulfate chains, due to their vast structural diversity, interact with a wide array of ligands including potent regulators of adhesion, migration, growth and survival. Frequently, ligands interact with cell surface heparan sulfate in conjunction with high affinity receptors. The consequent signaling can therefore be complex, but it is now known that syndecans are capable of independent signaling. This review is divided in two sections, and will first discuss how the assembly of heparan sulfate, the anabolic process, encodes information related to ligand binding and signaling. Second, we discuss how, in partial catabolic processes, new roles for HSPGs emerge that affect cell behavior. Examples from tumor studies are emphasized, since HSPGs may be altered in composition and distribution and may also represent targets for the development of new therapeutics. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
in
Trends in Glycoscience and Glycotechnology
volume
28
issue
163
pages
79 - 90
publisher
Gakushin Publishing Company
external identifiers
  • scopus:84988859636
ISSN
0915-7352
DOI
10.4052/tigg.1422.1E
language
English
LU publication?
no
id
96b57351-2032-4462-b83f-0c353b52cc8f
date added to LUP
2017-06-01 11:01:50
date last changed
2017-06-04 05:00:17
@article{96b57351-2032-4462-b83f-0c353b52cc8f,
  abstract     = {Virtually all animal cells express heparan sulfate proteoglycans on the cell surface and in the extracellular matrix. Syndecans are a major group of transmembrane proteoglycans functioning as receptors that mediate signal transmission from the extracellular microenvironment to the cell. Their heparan sulfate chains, due to their vast structural diversity, interact with a wide array of ligands including potent regulators of adhesion, migration, growth and survival. Frequently, ligands interact with cell surface heparan sulfate in conjunction with high affinity receptors. The consequent signaling can therefore be complex, but it is now known that syndecans are capable of independent signaling. This review is divided in two sections, and will first discuss how the assembly of heparan sulfate, the anabolic process, encodes information related to ligand binding and signaling. Second, we discuss how, in partial catabolic processes, new roles for HSPGs emerge that affect cell behavior. Examples from tumor studies are emphasized, since HSPGs may be altered in composition and distribution and may also represent targets for the development of new therapeutics. },
  author       = {Maciel Gomes, Angelica and Sinkeviciute, Dovile and Multhaupt, Hinke Arnolda B. and Yoneda, Atsuko and Couchman, John Robert},
  issn         = {0915-7352},
  language     = {eng},
  number       = {163},
  pages        = {79--90},
  publisher    = {Gakushin Publishing Company},
  series       = {Trends in Glycoscience and Glycotechnology},
  title        = {Syndecan Heparan Sulfate Proteoglycans: Regulation, Signaling and Impact on Tumor Biology},
  url          = {http://dx.doi.org/10.4052/tigg.1422.1E},
  volume       = {28},
  year         = {2016},
}