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Plasmodium parasites of birds have the most AT-rich genes of eukaryotes

Videvall, Elin LU (2018) In Microbial Genomics
Abstract
The genomic architecture of organisms, including nucleotide composition, can be highly variable, even among closely-related species. To better understand the causes leading to structural variation in genomes, information on distinct and diverse genomic features is needed. Malaria parasites are known for encompassing a wide range of genomic GC-content and it has long been thought that Plasmodium falciparum, the virulent malaria parasite of humans, has the most AT-biased eukaryotic genome. Here, I perform comparative genomic analyses of the most AT-rich eukaryotes sequenced to date, and show that the avian malaria parasites Plasmodium gallinaceum, P. ashfordi, and P. relictum have the most extreme coding sequences in terms of AT-bias. Their... (More)
The genomic architecture of organisms, including nucleotide composition, can be highly variable, even among closely-related species. To better understand the causes leading to structural variation in genomes, information on distinct and diverse genomic features is needed. Malaria parasites are known for encompassing a wide range of genomic GC-content and it has long been thought that Plasmodium falciparum, the virulent malaria parasite of humans, has the most AT-biased eukaryotic genome. Here, I perform comparative genomic analyses of the most AT-rich eukaryotes sequenced to date, and show that the avian malaria parasites Plasmodium gallinaceum, P. ashfordi, and P. relictum have the most extreme coding sequences in terms of AT-bias. Their mean GC-content is 21.21, 21.22 and 21.60 %, respectively, which is considerably lower than the transcriptome of P. falciparum (23.79 %) and other eukaryotes. This information enables a better understanding of genome evolution and raises the question of how certain organisms are able to prosper despite severe compositional constraints. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
keywords
GC-content, genome evolution, AT-bias
in
Microbial Genomics
DOI
10.1099/mgen.0.000150
language
English
LU publication?
no
id
96be4559-5c1a-4353-bcef-ad5654e7f5a5
alternative location
http://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.000150.v1
date added to LUP
2018-02-27 13:19:56
date last changed
2018-05-30 03:00:14
@article{96be4559-5c1a-4353-bcef-ad5654e7f5a5,
  abstract     = {The genomic architecture of organisms, including nucleotide composition, can be highly variable, even among closely-related species. To better understand the causes leading to structural variation in genomes, information on distinct and diverse genomic features is needed. Malaria parasites are known for encompassing a wide range of genomic GC-content and it has long been thought that Plasmodium falciparum, the virulent malaria parasite of humans, has the most AT-biased eukaryotic genome. Here, I perform comparative genomic analyses of the most AT-rich eukaryotes sequenced to date, and show that the avian malaria parasites Plasmodium gallinaceum, P. ashfordi, and P. relictum have the most extreme coding sequences in terms of AT-bias. Their mean GC-content is 21.21, 21.22 and 21.60 %, respectively, which is considerably lower than the transcriptome of P. falciparum (23.79 %) and other eukaryotes. This information enables a better understanding of genome evolution and raises the question of how certain organisms are able to prosper despite severe compositional constraints.},
  author       = {Videvall, Elin},
  keyword      = {GC-content,genome evolution,AT-bias},
  language     = {eng},
  month        = {01},
  series       = {Microbial Genomics},
  title        = {Plasmodium parasites of birds have the most AT-rich genes of eukaryotes},
  url          = {http://dx.doi.org/10.1099/mgen.0.000150},
  year         = {2018},
}