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Augmenting Glioblastoma Chemotherapy with Polymers

Skinner, Matthew; Ward, Sarah M.; Nilsson, Carol L. LU and Emrick, Todd (2018) In ACS Chemical Neuroscience 9(1). p.8-10
Abstract

Chemotherapeutics are vital for treating brain tumors such as glioblastoma, an aggressive and prolific cancer predominantly treated with DNA alkylating agents. The efficacy of antiglioblastoma drugs, such as temozolomide, is limited by their rapid clearance and instability under normal physiological conditions. Both local and systemic polymer-based therapeutics have shown promise for treating many cancers, and as such there is a growing interest in applying polymer techniques to augment the efficacy and stability of glioblastoma chemotherapeutics. Notably, brain tumor chemotherapy presents unique challenges and will require tailored delivery systems to develop markedly improved treatments.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
brain tumor, chemotherapy, Glioblastoma
in
ACS Chemical Neuroscience
volume
9
issue
1
pages
3 pages
publisher
The American Chemical Society
external identifiers
  • scopus:85040648021
ISSN
1948-7193
DOI
10.1021/acschemneuro.7b00168
language
English
LU publication?
yes
id
96fc7be5-e4a0-4417-baa0-946a55595423
date added to LUP
2018-01-30 10:59:39
date last changed
2018-05-29 11:06:14
@article{96fc7be5-e4a0-4417-baa0-946a55595423,
  abstract     = {<p>Chemotherapeutics are vital for treating brain tumors such as glioblastoma, an aggressive and prolific cancer predominantly treated with DNA alkylating agents. The efficacy of antiglioblastoma drugs, such as temozolomide, is limited by their rapid clearance and instability under normal physiological conditions. Both local and systemic polymer-based therapeutics have shown promise for treating many cancers, and as such there is a growing interest in applying polymer techniques to augment the efficacy and stability of glioblastoma chemotherapeutics. Notably, brain tumor chemotherapy presents unique challenges and will require tailored delivery systems to develop markedly improved treatments.</p>},
  author       = {Skinner, Matthew and Ward, Sarah M. and Nilsson, Carol L. and Emrick, Todd},
  issn         = {1948-7193},
  keyword      = {brain tumor,chemotherapy,Glioblastoma},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {8--10},
  publisher    = {The American Chemical Society},
  series       = {ACS Chemical Neuroscience},
  title        = {Augmenting Glioblastoma Chemotherapy with Polymers},
  url          = {http://dx.doi.org/10.1021/acschemneuro.7b00168},
  volume       = {9},
  year         = {2018},
}