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The effect of total body microwave hyperthermia and hepatic artery ligation on liver tumors—an experimental study in rats

Carlsson, Goran ; Hafström, Larsolof ; Hugander, Anders ; Jönsson, Per‐Ebbe ‐E ; Bolmsjö, Magnus and Persson, Bertil LU (1983) In Journal of Surgical Oncology 22(1). p.37-40
Abstract

The effect of general microwave hyperthermia and hepatic artery ligation (HAL) was tested on Wistar rats with a transplanted N‐methyl‐N‐nitroso‐guanidine‐induced adenocarcinoma in the liver. Total body hyperthermia (41.5°C for 1 hour, three times during 24 hours) was given on the same day as HAL, and 1, 2, and 3 days after. HAL induced a slower tumor growth than untreated controls. No additive effect was registered when total body microwave hyperthermia was added to HAL. When hyperthermia was added 2 days after HAL, there was a transient decrease in tumor volume as in the HAL series. Total body microwave hyperthermia added 3 days after HAL induced a faster tumor growth than after HAL alone. When hyperthermia was added the same day and 1... (More)

The effect of general microwave hyperthermia and hepatic artery ligation (HAL) was tested on Wistar rats with a transplanted N‐methyl‐N‐nitroso‐guanidine‐induced adenocarcinoma in the liver. Total body hyperthermia (41.5°C for 1 hour, three times during 24 hours) was given on the same day as HAL, and 1, 2, and 3 days after. HAL induced a slower tumor growth than untreated controls. No additive effect was registered when total body microwave hyperthermia was added to HAL. When hyperthermia was added 2 days after HAL, there was a transient decrease in tumor volume as in the HAL series. Total body microwave hyperthermia added 3 days after HAL induced a faster tumor growth than after HAL alone. When hyperthermia was added the same day and 1 day after HAL, there was a 50% mortality.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
keywords
hepatic artery ligation, hyperthermia, liver tumor, microwaves
in
Journal of Surgical Oncology
volume
22
issue
1
pages
4 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:6823115
  • scopus:0020658114
ISSN
0022-4790
DOI
10.1002/jso.2930220110
language
English
LU publication?
yes
id
97050baa-b08e-4f57-a669-1452d9cdbd6b
date added to LUP
2020-05-07 21:28:55
date last changed
2021-01-03 06:16:22
@article{97050baa-b08e-4f57-a669-1452d9cdbd6b,
  abstract     = {<p>The effect of general microwave hyperthermia and hepatic artery ligation (HAL) was tested on Wistar rats with a transplanted N‐methyl‐N‐nitroso‐guanidine‐induced adenocarcinoma in the liver. Total body hyperthermia (41.5°C for 1 hour, three times during 24 hours) was given on the same day as HAL, and 1, 2, and 3 days after. HAL induced a slower tumor growth than untreated controls. No additive effect was registered when total body microwave hyperthermia was added to HAL. When hyperthermia was added 2 days after HAL, there was a transient decrease in tumor volume as in the HAL series. Total body microwave hyperthermia added 3 days after HAL induced a faster tumor growth than after HAL alone. When hyperthermia was added the same day and 1 day after HAL, there was a 50% mortality.</p>},
  author       = {Carlsson, Goran and Hafström, Larsolof and Hugander, Anders and Jönsson, Per‐Ebbe ‐E and Bolmsjö, Magnus and Persson, Bertil},
  issn         = {0022-4790},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {37--40},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Surgical Oncology},
  title        = {The effect of total body microwave hyperthermia and hepatic artery ligation on liver tumors—an experimental study in rats},
  url          = {http://dx.doi.org/10.1002/jso.2930220110},
  doi          = {10.1002/jso.2930220110},
  volume       = {22},
  year         = {1983},
}