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Fetal growth restriction in preterm infants and cardiovascular function at five years of age

Mikkola, Kaija; Leipala, Jaana; Boldt, Talvikki and Fellman, Vineta LU (2007) In Journal of Pediatrics 151(5). p.494-499
Abstract
Objectives We have previously reported an increased cardiac workload in newborn preterm small (SGA) infants, but not in infants appropriate for gestational age (AGA). We hypothesized that these cardiovascular changes win persist at follow-tip at 5 years of age. Study design We assessed blood pressure, echocardiography, and shin perfusion with laser Doppler flowmetry in 22 SGA (S21 +/- 248 g. 28.5 +/- 2:5 gestational weeks) and in 25 AGA (1065 +/- 241 g, 27.6 +/- 0.8 weeks) preterm children at age 5 years. Laser Doppler flowmetry also was used in 13 control children (3982 +/- 425 g, 40.4 +/- 1.8 weeks). Results The preterm children in both the SGA and AGA groups had similar higher systolic blood pressures, increased interventricular septum... (More)
Objectives We have previously reported an increased cardiac workload in newborn preterm small (SGA) infants, but not in infants appropriate for gestational age (AGA). We hypothesized that these cardiovascular changes win persist at follow-tip at 5 years of age. Study design We assessed blood pressure, echocardiography, and shin perfusion with laser Doppler flowmetry in 22 SGA (S21 +/- 248 g. 28.5 +/- 2:5 gestational weeks) and in 25 AGA (1065 +/- 241 g, 27.6 +/- 0.8 weeks) preterm children at age 5 years. Laser Doppler flowmetry also was used in 13 control children (3982 +/- 425 g, 40.4 +/- 1.8 weeks). Results The preterm children in both the SGA and AGA groups had similar higher systolic blood pressures, increased interventricular septum thicknesses, and smaller left ventricular end-diastolic diameters compared with population reference values. Maximal endothelium-independent perfusion to sodium nitroprusside was higher and maximal endothelium-dependent perfusion to acetylcholine reached a plateau earlier in the AGA preterm group than in the control group. Conclusions Prematurity may, impair cardiovascular function independently of intrauterine growth restriction. Altered cardiac dimensions and differences in perfusion responses may reflect increased cardiac afterload. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Pediatrics
volume
151
issue
5
pages
494 - 499
publisher
Academic Press
external identifiers
  • wos:000250815900012
  • scopus:38449088069
ISSN
1097-6833
DOI
10.1016/j.jpeds.2007.04.030
language
English
LU publication?
yes
id
5ceb6c27-4114-4987-afb9-83235ee22344 (old id 971872)
date added to LUP
2008-01-30 13:24:48
date last changed
2017-08-13 03:28:40
@article{5ceb6c27-4114-4987-afb9-83235ee22344,
  abstract     = {Objectives We have previously reported an increased cardiac workload in newborn preterm small (SGA) infants, but not in infants appropriate for gestational age (AGA). We hypothesized that these cardiovascular changes win persist at follow-tip at 5 years of age. Study design We assessed blood pressure, echocardiography, and shin perfusion with laser Doppler flowmetry in 22 SGA (S21 +/- 248 g. 28.5 +/- 2:5 gestational weeks) and in 25 AGA (1065 +/- 241 g, 27.6 +/- 0.8 weeks) preterm children at age 5 years. Laser Doppler flowmetry also was used in 13 control children (3982 +/- 425 g, 40.4 +/- 1.8 weeks). Results The preterm children in both the SGA and AGA groups had similar higher systolic blood pressures, increased interventricular septum thicknesses, and smaller left ventricular end-diastolic diameters compared with population reference values. Maximal endothelium-independent perfusion to sodium nitroprusside was higher and maximal endothelium-dependent perfusion to acetylcholine reached a plateau earlier in the AGA preterm group than in the control group. Conclusions Prematurity may, impair cardiovascular function independently of intrauterine growth restriction. Altered cardiac dimensions and differences in perfusion responses may reflect increased cardiac afterload.},
  author       = {Mikkola, Kaija and Leipala, Jaana and Boldt, Talvikki and Fellman, Vineta},
  issn         = {1097-6833},
  language     = {eng},
  number       = {5},
  pages        = {494--499},
  publisher    = {Academic Press},
  series       = {Journal of Pediatrics},
  title        = {Fetal growth restriction in preterm infants and cardiovascular function at five years of age},
  url          = {http://dx.doi.org/10.1016/j.jpeds.2007.04.030},
  volume       = {151},
  year         = {2007},
}