Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Epithelial synthesis of tenascin at tips of growing bronchi and graded accumulation in basement membrane and mesenchyme

Koch, M ; Wehrle-Haller, B ; Baumgartner, S LU orcid ; Spring, J ; Brubacher, D and Chiquet, M (1991) In Experimental Cell Research 194(2). p.297-300
Abstract

The extracellular matrix protein, tenascin, has been proposed as mediator in epithelial-mesenchymal interactions because of its characteristic distribution during embryogenesis. Here we compared the accumulation of tenascin and laminin in the early chicken lung bud. Laminin is deposited in the basement membrane, starting at the tips and increasing along the shafts of growing primary and secondary bronchi. In contrast, tenascin accumulation is highest in basement membranes and mesenchyme at sites where new bronchial branches are formed. By in situ hybridization, tenascin mRNA was found to be produced exclusively by the epithelium at sites of active growth of bronchial tubes.

Please use this url to cite or link to this publication:
author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Antibodies, Monoclonal, Basement Membrane/cytology, Bronchi/cytology, Cell Adhesion Molecules, Neuronal/analysis, Chick Embryo, Cloning, Molecular, Epithelial Cells, Epithelium/physiology, Extracellular Matrix Proteins/analysis, Fluorescent Antibody Technique, Laminin/analysis, Nucleic Acid Hybridization, Tenascin
in
Experimental Cell Research
volume
194
issue
2
pages
297 - 300
publisher
Academic Press
external identifiers
  • pmid:1709104
  • scopus:0025729035
ISSN
0014-4827
DOI
10.1016/0014-4827(91)90368-5
language
English
LU publication?
no
id
97231c16-ab80-451c-9dee-07e11af6a9c5
date added to LUP
2019-05-21 14:25:08
date last changed
2024-04-02 03:50:12
@article{97231c16-ab80-451c-9dee-07e11af6a9c5,
  abstract     = {{<p>The extracellular matrix protein, tenascin, has been proposed as mediator in epithelial-mesenchymal interactions because of its characteristic distribution during embryogenesis. Here we compared the accumulation of tenascin and laminin in the early chicken lung bud. Laminin is deposited in the basement membrane, starting at the tips and increasing along the shafts of growing primary and secondary bronchi. In contrast, tenascin accumulation is highest in basement membranes and mesenchyme at sites where new bronchial branches are formed. By in situ hybridization, tenascin mRNA was found to be produced exclusively by the epithelium at sites of active growth of bronchial tubes.</p>}},
  author       = {{Koch, M and Wehrle-Haller, B and Baumgartner, S and Spring, J and Brubacher, D and Chiquet, M}},
  issn         = {{0014-4827}},
  keywords     = {{Animals; Antibodies, Monoclonal; Basement Membrane/cytology; Bronchi/cytology; Cell Adhesion Molecules, Neuronal/analysis; Chick Embryo; Cloning, Molecular; Epithelial Cells; Epithelium/physiology; Extracellular Matrix Proteins/analysis; Fluorescent Antibody Technique; Laminin/analysis; Nucleic Acid Hybridization; Tenascin}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{297--300}},
  publisher    = {{Academic Press}},
  series       = {{Experimental Cell Research}},
  title        = {{Epithelial synthesis of tenascin at tips of growing bronchi and graded accumulation in basement membrane and mesenchyme}},
  url          = {{http://dx.doi.org/10.1016/0014-4827(91)90368-5}},
  doi          = {{10.1016/0014-4827(91)90368-5}},
  volume       = {{194}},
  year         = {{1991}},
}