Epithelial synthesis of tenascin at tips of growing bronchi and graded accumulation in basement membrane and mesenchyme
(1991) In Experimental Cell Research 194(2). p.297-300- Abstract
The extracellular matrix protein, tenascin, has been proposed as mediator in epithelial-mesenchymal interactions because of its characteristic distribution during embryogenesis. Here we compared the accumulation of tenascin and laminin in the early chicken lung bud. Laminin is deposited in the basement membrane, starting at the tips and increasing along the shafts of growing primary and secondary bronchi. In contrast, tenascin accumulation is highest in basement membranes and mesenchyme at sites where new bronchial branches are formed. By in situ hybridization, tenascin mRNA was found to be produced exclusively by the epithelium at sites of active growth of bronchial tubes.
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https://lup.lub.lu.se/record/97231c16-ab80-451c-9dee-07e11af6a9c5
- author
- Koch, M ; Wehrle-Haller, B ; Baumgartner, S LU ; Spring, J ; Brubacher, D and Chiquet, M
- publishing date
- 1991-06
- type
- Contribution to journal
- publication status
- published
- keywords
- Animals, Antibodies, Monoclonal, Basement Membrane/cytology, Bronchi/cytology, Cell Adhesion Molecules, Neuronal/analysis, Chick Embryo, Cloning, Molecular, Epithelial Cells, Epithelium/physiology, Extracellular Matrix Proteins/analysis, Fluorescent Antibody Technique, Laminin/analysis, Nucleic Acid Hybridization, Tenascin
- in
- Experimental Cell Research
- volume
- 194
- issue
- 2
- pages
- 297 - 300
- publisher
- Academic Press
- external identifiers
-
- pmid:1709104
- scopus:0025729035
- ISSN
- 0014-4827
- DOI
- 10.1016/0014-4827(91)90368-5
- language
- English
- LU publication?
- no
- id
- 97231c16-ab80-451c-9dee-07e11af6a9c5
- date added to LUP
- 2019-05-21 14:25:08
- date last changed
- 2024-04-02 03:50:12
@article{97231c16-ab80-451c-9dee-07e11af6a9c5, abstract = {{<p>The extracellular matrix protein, tenascin, has been proposed as mediator in epithelial-mesenchymal interactions because of its characteristic distribution during embryogenesis. Here we compared the accumulation of tenascin and laminin in the early chicken lung bud. Laminin is deposited in the basement membrane, starting at the tips and increasing along the shafts of growing primary and secondary bronchi. In contrast, tenascin accumulation is highest in basement membranes and mesenchyme at sites where new bronchial branches are formed. By in situ hybridization, tenascin mRNA was found to be produced exclusively by the epithelium at sites of active growth of bronchial tubes.</p>}}, author = {{Koch, M and Wehrle-Haller, B and Baumgartner, S and Spring, J and Brubacher, D and Chiquet, M}}, issn = {{0014-4827}}, keywords = {{Animals; Antibodies, Monoclonal; Basement Membrane/cytology; Bronchi/cytology; Cell Adhesion Molecules, Neuronal/analysis; Chick Embryo; Cloning, Molecular; Epithelial Cells; Epithelium/physiology; Extracellular Matrix Proteins/analysis; Fluorescent Antibody Technique; Laminin/analysis; Nucleic Acid Hybridization; Tenascin}}, language = {{eng}}, number = {{2}}, pages = {{297--300}}, publisher = {{Academic Press}}, series = {{Experimental Cell Research}}, title = {{Epithelial synthesis of tenascin at tips of growing bronchi and graded accumulation in basement membrane and mesenchyme}}, url = {{http://dx.doi.org/10.1016/0014-4827(91)90368-5}}, doi = {{10.1016/0014-4827(91)90368-5}}, volume = {{194}}, year = {{1991}}, }