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Signal frequency studies of an environmental application of a 65 nm region ion sensitive field effect transistor sensor

Risveden, Klas LU ; Bhand, Sunil LU ; Pontén, Fredrik LU ; Anden, Thomas; Calander, Nils; Willander, Magnus and Danielsson, Bengt LU (2007) In Sensors and Actuators B: Chemical 127(1). p.198-203
Abstract
A rapid and sensitive novel type of bioelectronic Region Ion Sensitive Field Effect Transistor (RISFET) nanosensor was constructed on a chip with a 65 nm sensing electrode gap. The RISFET nanosensor was demonstrated for the environmental pesticide analysis of neurotoxic organocarbamate/carbofuran. The linear range for carbofuran analysis is ac signal frequency dependent, studied in the range (500 down-0.5 Hz, 50 mV(peak-peak) ac) and a bias voltage applied between the bottom capacitor plate and the electrodes. The signal current response is measured using a low-noise pico ammeter. The inhibition of acetylcholinesterase (AChE) by carbofuran was detectable in a logarithmic linear range (0.1-100nM) at 1.08 Hz, with a lower limit of detection... (More)
A rapid and sensitive novel type of bioelectronic Region Ion Sensitive Field Effect Transistor (RISFET) nanosensor was constructed on a chip with a 65 nm sensing electrode gap. The RISFET nanosensor was demonstrated for the environmental pesticide analysis of neurotoxic organocarbamate/carbofuran. The linear range for carbofuran analysis is ac signal frequency dependent, studied in the range (500 down-0.5 Hz, 50 mV(peak-peak) ac) and a bias voltage applied between the bottom capacitor plate and the electrodes. The signal current response is measured using a low-noise pico ammeter. The inhibition of acetylcholinesterase (AChE) by carbofuran was detectable in a logarithmic linear range (0.1-100nM) at 1.08 Hz, with a lower limit of detection of inhibition 0.1 nM with 10 min incubation time. The sensor is based on the principle of focusing charged reaction products with an electrical field in a region between the sensing electrodes. The current measurement by the sensor electrodes is correlated to the composition of the sample. The carbofuran detection is based on the ability to inhibit the enzyme AChE. The RISFET sensor chip is fabricated using conventional electron beam lithography. The encompassed sensor volume in the "nanocell" is in the attoliter range. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
carbofuran, nanosensor, bioelectronic, RISFET, conducting channel
in
Sensors and Actuators B: Chemical
volume
127
issue
1
pages
198 - 203
publisher
Elsevier
external identifiers
  • wos:000250691100031
  • scopus:34848846350
ISSN
0925-4005
DOI
10.1016/j.snb.2007.07.046
language
English
LU publication?
yes
id
8161c4f7-9b9d-4018-aa58-b65eedfab816 (old id 972382)
date added to LUP
2008-01-30 14:09:04
date last changed
2017-01-01 07:01:51
@article{8161c4f7-9b9d-4018-aa58-b65eedfab816,
  abstract     = {A rapid and sensitive novel type of bioelectronic Region Ion Sensitive Field Effect Transistor (RISFET) nanosensor was constructed on a chip with a 65 nm sensing electrode gap. The RISFET nanosensor was demonstrated for the environmental pesticide analysis of neurotoxic organocarbamate/carbofuran. The linear range for carbofuran analysis is ac signal frequency dependent, studied in the range (500 down-0.5 Hz, 50 mV(peak-peak) ac) and a bias voltage applied between the bottom capacitor plate and the electrodes. The signal current response is measured using a low-noise pico ammeter. The inhibition of acetylcholinesterase (AChE) by carbofuran was detectable in a logarithmic linear range (0.1-100nM) at 1.08 Hz, with a lower limit of detection of inhibition 0.1 nM with 10 min incubation time. The sensor is based on the principle of focusing charged reaction products with an electrical field in a region between the sensing electrodes. The current measurement by the sensor electrodes is correlated to the composition of the sample. The carbofuran detection is based on the ability to inhibit the enzyme AChE. The RISFET sensor chip is fabricated using conventional electron beam lithography. The encompassed sensor volume in the "nanocell" is in the attoliter range.},
  author       = {Risveden, Klas and Bhand, Sunil and Pontén, Fredrik and Anden, Thomas and Calander, Nils and Willander, Magnus and Danielsson, Bengt},
  issn         = {0925-4005},
  keyword      = {carbofuran,nanosensor,bioelectronic,RISFET,conducting channel},
  language     = {eng},
  number       = {1},
  pages        = {198--203},
  publisher    = {Elsevier},
  series       = {Sensors and Actuators B: Chemical},
  title        = {Signal frequency studies of an environmental application of a 65 nm region ion sensitive field effect transistor sensor},
  url          = {http://dx.doi.org/10.1016/j.snb.2007.07.046},
  volume       = {127},
  year         = {2007},
}