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Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment

Tfelt-Hansen, P and Edvinsson, Lars LU (2007) In Cephalalgia 27(10). p.1091-1093
Abstract
The pharmacokinetics of antimigraine drugs zolmitriptan and sumatriptan varied considerably with a fourfold to 10-fold variation in plasma levels. In addition, the pharmacodynamics of triptans as investigated in vitro also varied considerably. In theory, there should probably be a 10-fold variation in doses available, but in clinical practice a fourfold difference in doses will probably cover the needs of most patients.
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pharmacokinetics, migraine, variability, pharmacodynamics
in
Cephalalgia
volume
27
issue
10
pages
1091 - 1093
publisher
SAGE Publications
external identifiers
  • wos:000249659500001
  • scopus:34748846390
ISSN
0333-1024
DOI
10.1111/j.1468-2982.2007.01372.x
language
English
LU publication?
yes
id
972a1f47-ed1d-4594-b6a0-5098321036dd (old id 656189)
date added to LUP
2016-04-01 17:03:55
date last changed
2025-10-14 12:54:13
@article{972a1f47-ed1d-4594-b6a0-5098321036dd,
  abstract     = {{The pharmacokinetics of antimigraine drugs zolmitriptan and sumatriptan varied considerably with a fourfold to 10-fold variation in plasma levels. In addition, the pharmacodynamics of triptans as investigated in vitro also varied considerably. In theory, there should probably be a 10-fold variation in doses available, but in clinical practice a fourfold difference in doses will probably cover the needs of most patients.}},
  author       = {{Tfelt-Hansen, P and Edvinsson, Lars}},
  issn         = {{0333-1024}},
  keywords     = {{pharmacokinetics; migraine; variability; pharmacodynamics}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1091--1093}},
  publisher    = {{SAGE Publications}},
  series       = {{Cephalalgia}},
  title        = {{Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment}},
  url          = {{http://dx.doi.org/10.1111/j.1468-2982.2007.01372.x}},
  doi          = {{10.1111/j.1468-2982.2007.01372.x}},
  volume       = {{27}},
  year         = {{2007}},
}