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PET biomarkers for Tau pathology

Leuzy, Antoine LU ; Heurling, Kerstin and Schöll, Michael LU (2024) p.235-242
Abstract

The aggregation and accumulation of pathologic forms of the microtubule-associated tau protein into fibrils, eventually forming characteristic tangle pathology, hallmarks the majority of all dementia disorders which constitute the most prevalent family of neurodegenerative disorders. These so-called tauopathies are difficult to identify and diagnose, especially at early disease stages. The relatively recent development of positron emission tomography tracers to visualize, map, and quantify tau pathology in the living brain has already provided substantial information about the temporal and spatial characteristics of tau accumulation during disease development, holding promise to serve as a highly valuable diagnostic tool in research and... (More)

The aggregation and accumulation of pathologic forms of the microtubule-associated tau protein into fibrils, eventually forming characteristic tangle pathology, hallmarks the majority of all dementia disorders which constitute the most prevalent family of neurodegenerative disorders. These so-called tauopathies are difficult to identify and diagnose, especially at early disease stages. The relatively recent development of positron emission tomography tracers to visualize, map, and quantify tau pathology in the living brain has already provided substantial information about the temporal and spatial characteristics of tau accumulation during disease development, holding promise to serve as a highly valuable diagnostic tool in research and clinical settings. This chapter describes the current state of research employing tau biomarkers derived from neuroimaging with PET as well as recent technical developments in this field.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Radiopharmaceuticals : A Guide to PET/CT and PET/MRI - A Guide to PET/CT and PET/MRI
pages
8 pages
publisher
Springer Nature
external identifiers
  • scopus:105001271000
ISBN
9783031541964
9783031541957
DOI
10.1007/978-3-031-54196-4_13
language
English
LU publication?
yes
id
9763b120-3a97-45af-a853-b1767cab139f
date added to LUP
2025-09-15 12:26:38
date last changed
2025-10-02 13:37:48
@inbook{9763b120-3a97-45af-a853-b1767cab139f,
  abstract     = {{<p>The aggregation and accumulation of pathologic forms of the microtubule-associated tau protein into fibrils, eventually forming characteristic tangle pathology, hallmarks the majority of all dementia disorders which constitute the most prevalent family of neurodegenerative disorders. These so-called tauopathies are difficult to identify and diagnose, especially at early disease stages. The relatively recent development of positron emission tomography tracers to visualize, map, and quantify tau pathology in the living brain has already provided substantial information about the temporal and spatial characteristics of tau accumulation during disease development, holding promise to serve as a highly valuable diagnostic tool in research and clinical settings. This chapter describes the current state of research employing tau biomarkers derived from neuroimaging with PET as well as recent technical developments in this field.</p>}},
  author       = {{Leuzy, Antoine and Heurling, Kerstin and Schöll, Michael}},
  booktitle    = {{Radiopharmaceuticals : A Guide to PET/CT and PET/MRI}},
  isbn         = {{9783031541964}},
  language     = {{eng}},
  pages        = {{235--242}},
  publisher    = {{Springer Nature}},
  title        = {{PET biomarkers for Tau pathology}},
  url          = {{http://dx.doi.org/10.1007/978-3-031-54196-4_13}},
  doi          = {{10.1007/978-3-031-54196-4_13}},
  year         = {{2024}},
}