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Cross-reacting Tumor-associated Antigen(s) of Adenovirus Type 9-induced Fibroadenomas and a Chemically Induced Mammary Carcinoma in Rats

Ankerst, J. LU orcid ; Steele, G. and Sjögren, H. O. LU (1974) In Cancer Research 34(8). p.1794-1800
Abstract

Cross-reactivities among tumor-associated antigens of rat mammary fibroadenomas and among these fribroadenomas and a rat mammary carcinoma were investigated by in vitro techniques. Lymphocytes from five female W/Fu rats bearing mammary fibroadenomas were found to share a common reactivity against fibroadenoma target cells, as demonstrated by lymphocyte cytotoxicity tests on iododeoxyuridine-l25I-labeled target cells and by microcytotoxicity tests. These lymphocytes were also cytotoxic to target cells derived from a rat mammary carcinoma induced by 3,2'-dimethyl-4-aminobiphenyl. Inversely, lymphocytes from a female W/Fu rat bearing this 3,2'-dimethyl-4-aminobiphenyl-induced mammary carcinoma were cytotoxic to the carcinoma and... (More)

Cross-reactivities among tumor-associated antigens of rat mammary fibroadenomas and among these fribroadenomas and a rat mammary carcinoma were investigated by in vitro techniques. Lymphocytes from five female W/Fu rats bearing mammary fibroadenomas were found to share a common reactivity against fibroadenoma target cells, as demonstrated by lymphocyte cytotoxicity tests on iododeoxyuridine-l25I-labeled target cells and by microcytotoxicity tests. These lymphocytes were also cytotoxic to target cells derived from a rat mammary carcinoma induced by 3,2'-dimethyl-4-aminobiphenyl. Inversely, lymphocytes from a female W/Fu rat bearing this 3,2'-dimethyl-4-aminobiphenyl-induced mammary carcinoma were cytotoxic to the carcinoma and the fibroadenoma target cells. Neither the immune lymphocytes from fibroadenoma-bearing rats nor those from the rats with the mammary carcinoma were cytotoxic to polyoma virus-induced sarcoma cells or to normal rat breast cells. Neither immune lymphocytes from rats with polyoma tumors nor those bearing chemically induced colon carcinomas demonstrated cellular immunity against either mammary fibroadenoma or mammary carcinoma target cells. Sera from each of the fibroadenoma-bearing rats inhibited the cytotoxic effect of lymphocytes from rats bearing fibroadenoma or carcinoma against both mammary fibroadenoma and carcinoma target cells. Sera from the rat with the 3,2'-dimethyl-4-aminobiphenyl-induced mammary carcinoma inhibited the activity of its own lymphocytes on either fibroadenoma or carcinoma target cells. They also blocked the cytotoxicity of fibroadenoma-immune lymphocytes to fibroadenoma or to carcinoma target cells. The blocking sera of mammary fibroadenomatous and carcinomatous rats did not inhibit the cytotoxic effect of lymphocytes from polyoma sarcoma-bearing rats against polyoma tumor cells. Additionally, sera from rats with either polyoma virus-induced tumors or colon carcinomas, which blocked in their respective systems, did not inhibit the in vitro activity of mammary fibroadenoma or carcinomaimmune lymphocytes on mammary fibroadenoma or cacinoma target cells. These results indicate a common tumor-associated antigenicity among the mammary fibroadenomas and a shared (tissue type-specific?) antigen between the mammary fibroadenomas and the chemically induced mammary carcinoma.

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Contribution to journal
publication status
published
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in
Cancer Research
volume
34
issue
8
pages
7 pages
publisher
American Association for Cancer Research Inc.
external identifiers
  • scopus:0016156008
  • pmid:4367178
ISSN
0008-5472
language
English
LU publication?
yes
id
9778d32f-d9c2-4b40-a6e9-021948c7666b
date added to LUP
2021-01-25 10:38:19
date last changed
2024-01-03 05:48:17
@article{9778d32f-d9c2-4b40-a6e9-021948c7666b,
  abstract     = {{<p>Cross-reactivities among tumor-associated antigens of rat mammary fibroadenomas and among these fribroadenomas and a rat mammary carcinoma were investigated by in vitro techniques. Lymphocytes from five female W/Fu rats bearing mammary fibroadenomas were found to share a common reactivity against fibroadenoma target cells, as demonstrated by lymphocyte cytotoxicity tests on iododeoxyuridine-<sup>l25</sup>I-labeled target cells and by microcytotoxicity tests. These lymphocytes were also cytotoxic to target cells derived from a rat mammary carcinoma induced by 3,2'-dimethyl-4-aminobiphenyl. Inversely, lymphocytes from a female W/Fu rat bearing this 3,2'-dimethyl-4-aminobiphenyl-induced mammary carcinoma were cytotoxic to the carcinoma and the fibroadenoma target cells. Neither the immune lymphocytes from fibroadenoma-bearing rats nor those from the rats with the mammary carcinoma were cytotoxic to polyoma virus-induced sarcoma cells or to normal rat breast cells. Neither immune lymphocytes from rats with polyoma tumors nor those bearing chemically induced colon carcinomas demonstrated cellular immunity against either mammary fibroadenoma or mammary carcinoma target cells. Sera from each of the fibroadenoma-bearing rats inhibited the cytotoxic effect of lymphocytes from rats bearing fibroadenoma or carcinoma against both mammary fibroadenoma and carcinoma target cells. Sera from the rat with the 3,2'-dimethyl-4-aminobiphenyl-induced mammary carcinoma inhibited the activity of its own lymphocytes on either fibroadenoma or carcinoma target cells. They also blocked the cytotoxicity of fibroadenoma-immune lymphocytes to fibroadenoma or to carcinoma target cells. The blocking sera of mammary fibroadenomatous and carcinomatous rats did not inhibit the cytotoxic effect of lymphocytes from polyoma sarcoma-bearing rats against polyoma tumor cells. Additionally, sera from rats with either polyoma virus-induced tumors or colon carcinomas, which blocked in their respective systems, did not inhibit the in vitro activity of mammary fibroadenoma or carcinomaimmune lymphocytes on mammary fibroadenoma or cacinoma target cells. These results indicate a common tumor-associated antigenicity among the mammary fibroadenomas and a shared (tissue type-specific?) antigen between the mammary fibroadenomas and the chemically induced mammary carcinoma.</p>}},
  author       = {{Ankerst, J. and Steele, G. and Sjögren, H. O.}},
  issn         = {{0008-5472}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1794--1800}},
  publisher    = {{American Association for Cancer Research Inc.}},
  series       = {{Cancer Research}},
  title        = {{Cross-reacting Tumor-associated Antigen(s) of Adenovirus Type 9-induced Fibroadenomas and a Chemically Induced Mammary Carcinoma in Rats}},
  volume       = {{34}},
  year         = {{1974}},
}