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Evaluation of the toxicity of onyx compared with n-butyl 2-cyanoacrylate in the subarachnoid space of a rabbit model : An experimental research

Bakar, Bulent ; Oruckaptan, Hakan H. ; Hazer, Burcu D. LU orcid ; Saatci, Isil ; Atilla, Pergin ; Kılıc, Kamer and Muftuoglu, Sevda F. (2010) In Neuroradiology 52(2). p.125-134
Abstract

Introduction: The toxic effects of onyx, its solvent dimethyl sulphoxide (DMSO), and n-butyl 2-cyanoacrylate (NBCA) were evaluated after infusion into the subaracnoid space of a rabbit model. Methods: Each of the two various concentrations of onyx, pure DMSO, NBCA, and normal saline solution were percutaneously infused into the pontocerebellar cisternae of 39 domestic male albino rabbits, after which, the brain stems and medial cerebellar tissues were harvested for biochemical and histopathological studies. Results: The specimens infused in various concentration of onyx, DMSO, and NBCA showed neural tissue necrosis and edema with inflammatory cell infitration in the acute stage. Although the mean values of the lipid peroxidase in the... (More)

Introduction: The toxic effects of onyx, its solvent dimethyl sulphoxide (DMSO), and n-butyl 2-cyanoacrylate (NBCA) were evaluated after infusion into the subaracnoid space of a rabbit model. Methods: Each of the two various concentrations of onyx, pure DMSO, NBCA, and normal saline solution were percutaneously infused into the pontocerebellar cisternae of 39 domestic male albino rabbits, after which, the brain stems and medial cerebellar tissues were harvested for biochemical and histopathological studies. Results: The specimens infused in various concentration of onyx, DMSO, and NBCA showed neural tissue necrosis and edema with inflammatory cell infitration in the acute stage. Although the mean values of the lipid peroxidase in the control, saline, and NBCA groups were found to be almost similar, they were found to be low in the onyx and DMSO groups. Conclusion: This experimental study suggests that NBCA, and various concentrations of onyx and DMSO have toxic effects on the neural tissues of rabbits when infused into the subarachnoid space.

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author
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publishing date
type
Contribution to journal
publication status
published
keywords
DMSO, NBCA, Onyx, Subarachnoid, Toxicity
in
Neuroradiology
volume
52
issue
2
pages
125 - 134
publisher
Springer
external identifiers
  • scopus:77749249442
  • pmid:19756562
ISSN
0028-3940
DOI
10.1007/s00234-009-0594-8
language
English
LU publication?
no
id
97a3b9cb-06ef-466c-9ab8-cbedb09e4d7f
date added to LUP
2025-05-11 22:39:46
date last changed
2025-05-14 03:17:47
@article{97a3b9cb-06ef-466c-9ab8-cbedb09e4d7f,
  abstract     = {{<p>Introduction: The toxic effects of onyx, its solvent dimethyl sulphoxide (DMSO), and n-butyl 2-cyanoacrylate (NBCA) were evaluated after infusion into the subaracnoid space of a rabbit model. Methods: Each of the two various concentrations of onyx, pure DMSO, NBCA, and normal saline solution were percutaneously infused into the pontocerebellar cisternae of 39 domestic male albino rabbits, after which, the brain stems and medial cerebellar tissues were harvested for biochemical and histopathological studies. Results: The specimens infused in various concentration of onyx, DMSO, and NBCA showed neural tissue necrosis and edema with inflammatory cell infitration in the acute stage. Although the mean values of the lipid peroxidase in the control, saline, and NBCA groups were found to be almost similar, they were found to be low in the onyx and DMSO groups. Conclusion: This experimental study suggests that NBCA, and various concentrations of onyx and DMSO have toxic effects on the neural tissues of rabbits when infused into the subarachnoid space.</p>}},
  author       = {{Bakar, Bulent and Oruckaptan, Hakan H. and Hazer, Burcu D. and Saatci, Isil and Atilla, Pergin and Kılıc, Kamer and Muftuoglu, Sevda F.}},
  issn         = {{0028-3940}},
  keywords     = {{DMSO; NBCA; Onyx; Subarachnoid; Toxicity}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{125--134}},
  publisher    = {{Springer}},
  series       = {{Neuroradiology}},
  title        = {{Evaluation of the toxicity of onyx compared with n-butyl 2-cyanoacrylate in the subarachnoid space of a rabbit model : An experimental research}},
  url          = {{http://dx.doi.org/10.1007/s00234-009-0594-8}},
  doi          = {{10.1007/s00234-009-0594-8}},
  volume       = {{52}},
  year         = {{2010}},
}