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Starvation to Glucose Reprograms Development of Neurovascular Unit in Embryonic Retinal Cells

Özgümüs, Türküler ; Sulaieva, Oksana LU ; Jain, Ruchi LU ; Artner, Isabella LU and Lyssenko, Valeriya LU (2021) In Frontiers in Cell and Developmental Biology 9. p.1-11
Abstract

Perinatal exposure to starvation is a risk factor for development of severe retinopathy in adult patients with diabetes. However, the underlying mechanisms are not completely understood. In the present study, we shed light on molecular consequences of exposure to short-time glucose starvation on the transcriptome profile of mouse embryonic retinal cells. We found a profound downregulation of genes regulating development of retinal neurons, which was accompanied by reduced expression of genes encoding for glycolytic enzymes and glutamatergic signaling. At the same time, glial and vascular markers were upregulated, mimicking the diabetes-associated increase of angiogenesis-a hallmark of pathogenic features in diabetic retinopathy. Energy... (More)

Perinatal exposure to starvation is a risk factor for development of severe retinopathy in adult patients with diabetes. However, the underlying mechanisms are not completely understood. In the present study, we shed light on molecular consequences of exposure to short-time glucose starvation on the transcriptome profile of mouse embryonic retinal cells. We found a profound downregulation of genes regulating development of retinal neurons, which was accompanied by reduced expression of genes encoding for glycolytic enzymes and glutamatergic signaling. At the same time, glial and vascular markers were upregulated, mimicking the diabetes-associated increase of angiogenesis-a hallmark of pathogenic features in diabetic retinopathy. Energy deprivation as a consequence of starvation to glucose seems to be compensated by upregulation of genes involved in fatty acid elongation. Results from the present study demonstrate that short-term glucose deprivation during early fetal life differentially alters expression of metabolism- and function-related genes and could have detrimental and lasting effects on gene expression in the retinal neurons, glial cells, and vascular elements and thus potentially disrupting gene regulatory networks essential for the formation of the retinal neurovascular unit. Abnormal developmental programming during retinogenesis may serve as a trigger of reactive gliosis, accelerated neurodegeneration, and increased vascularization, which may promote development of severe retinopathy in patients with diabetes later in life.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Frontiers in Cell and Developmental Biology
volume
9
article number
726852
pages
1 - 11
publisher
Frontiers Media S. A.
external identifiers
  • pmid:34869314
  • scopus:85120486718
ISSN
2296-634X
DOI
10.3389/fcell.2021.726852
language
English
LU publication?
yes
additional info
Copyright © 2021 Özgümüs, Sulaieva, Jain, Artner and Lyssenko.
id
97b9c851-2a3f-4c71-9756-6ae66afdd4a2
date added to LUP
2022-01-17 11:16:14
date last changed
2025-01-13 21:12:36
@article{97b9c851-2a3f-4c71-9756-6ae66afdd4a2,
  abstract     = {{<p>Perinatal exposure to starvation is a risk factor for development of severe retinopathy in adult patients with diabetes. However, the underlying mechanisms are not completely understood. In the present study, we shed light on molecular consequences of exposure to short-time glucose starvation on the transcriptome profile of mouse embryonic retinal cells. We found a profound downregulation of genes regulating development of retinal neurons, which was accompanied by reduced expression of genes encoding for glycolytic enzymes and glutamatergic signaling. At the same time, glial and vascular markers were upregulated, mimicking the diabetes-associated increase of angiogenesis-a hallmark of pathogenic features in diabetic retinopathy. Energy deprivation as a consequence of starvation to glucose seems to be compensated by upregulation of genes involved in fatty acid elongation. Results from the present study demonstrate that short-term glucose deprivation during early fetal life differentially alters expression of metabolism- and function-related genes and could have detrimental and lasting effects on gene expression in the retinal neurons, glial cells, and vascular elements and thus potentially disrupting gene regulatory networks essential for the formation of the retinal neurovascular unit. Abnormal developmental programming during retinogenesis may serve as a trigger of reactive gliosis, accelerated neurodegeneration, and increased vascularization, which may promote development of severe retinopathy in patients with diabetes later in life.</p>}},
  author       = {{Özgümüs, Türküler and Sulaieva, Oksana and Jain, Ruchi and Artner, Isabella and Lyssenko, Valeriya}},
  issn         = {{2296-634X}},
  language     = {{eng}},
  pages        = {{1--11}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Cell and Developmental Biology}},
  title        = {{Starvation to Glucose Reprograms Development of Neurovascular Unit in Embryonic Retinal Cells}},
  url          = {{http://dx.doi.org/10.3389/fcell.2021.726852}},
  doi          = {{10.3389/fcell.2021.726852}},
  volume       = {{9}},
  year         = {{2021}},
}