A series of case studies illustrating the role of flow cytometry in the diagnostic work-up of myelodysplastic syndromes
(2023) In Cytometry Part B - Clinical Cytometry 104(1). p.87-97- Abstract
Current guidelines recommend flow cytometric analysis as part of the diagnostic assessment of patients with cytopenia suspected for myelodysplastic syndrome. Herein we describe the complete work-up of six cases using multimodal integrated diagnostics. Flow cytometry assessments are illustrated by plots from conventional and more recent analysis tools. The cases demonstrate the added value of flow cytometry in case of hypocellular, poor quality, or ambiguous bone marrow cytomorphology. Moreover, they demonstrate how immunophenotyping results support clinical decision-making in inconclusive and clinically ‘difficult’ cases.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/97e8388a-98ff-4ee3-b30f-ef4b8292999d
- author
- Westers, Theresia M. ; Saft, Leonie ; van der Velden, Vincent H.J. ; te Marvelde, Jeroen G. ; Dunlop, Alan ; Ireland, Robin ; Valent, Peter ; Porwit, Anna LU ; Béné, Marie C. and van de Loosdrecht, Arjan A.
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cytopenia, dysplasia, flow cytometry, integrated diagnostics, MDS
- in
- Cytometry Part B - Clinical Cytometry
- volume
- 104
- issue
- 1
- pages
- 87 - 97
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:35179296
- scopus:85124725693
- ISSN
- 1552-4949
- DOI
- 10.1002/cyto.b.22061
- language
- English
- LU publication?
- yes
- id
- 97e8388a-98ff-4ee3-b30f-ef4b8292999d
- date added to LUP
- 2022-04-14 11:36:41
- date last changed
- 2024-09-12 10:10:17
@article{97e8388a-98ff-4ee3-b30f-ef4b8292999d, abstract = {{<p>Current guidelines recommend flow cytometric analysis as part of the diagnostic assessment of patients with cytopenia suspected for myelodysplastic syndrome. Herein we describe the complete work-up of six cases using multimodal integrated diagnostics. Flow cytometry assessments are illustrated by plots from conventional and more recent analysis tools. The cases demonstrate the added value of flow cytometry in case of hypocellular, poor quality, or ambiguous bone marrow cytomorphology. Moreover, they demonstrate how immunophenotyping results support clinical decision-making in inconclusive and clinically ‘difficult’ cases.</p>}}, author = {{Westers, Theresia M. and Saft, Leonie and van der Velden, Vincent H.J. and te Marvelde, Jeroen G. and Dunlop, Alan and Ireland, Robin and Valent, Peter and Porwit, Anna and Béné, Marie C. and van de Loosdrecht, Arjan A.}}, issn = {{1552-4949}}, keywords = {{cytopenia; dysplasia; flow cytometry; integrated diagnostics; MDS}}, language = {{eng}}, number = {{1}}, pages = {{87--97}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Cytometry Part B - Clinical Cytometry}}, title = {{A series of case studies illustrating the role of flow cytometry in the diagnostic work-up of myelodysplastic syndromes}}, url = {{http://dx.doi.org/10.1002/cyto.b.22061}}, doi = {{10.1002/cyto.b.22061}}, volume = {{104}}, year = {{2023}}, }