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A series of case studies illustrating the role of flow cytometry in the diagnostic work-up of myelodysplastic syndromes

Westers, Theresia M. ; Saft, Leonie ; van der Velden, Vincent H.J. ; te Marvelde, Jeroen G. ; Dunlop, Alan ; Ireland, Robin ; Valent, Peter ; Porwit, Anna LU ; Béné, Marie C. and van de Loosdrecht, Arjan A. (2023) In Cytometry Part B - Clinical Cytometry 104(1). p.87-97
Abstract

Current guidelines recommend flow cytometric analysis as part of the diagnostic assessment of patients with cytopenia suspected for myelodysplastic syndrome. Herein we describe the complete work-up of six cases using multimodal integrated diagnostics. Flow cytometry assessments are illustrated by plots from conventional and more recent analysis tools. The cases demonstrate the added value of flow cytometry in case of hypocellular, poor quality, or ambiguous bone marrow cytomorphology. Moreover, they demonstrate how immunophenotyping results support clinical decision-making in inconclusive and clinically ‘difficult’ cases.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cytopenia, dysplasia, flow cytometry, integrated diagnostics, MDS
in
Cytometry Part B - Clinical Cytometry
volume
104
issue
1
pages
87 - 97
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85124725693
  • pmid:35179296
ISSN
1552-4949
DOI
10.1002/cyto.b.22061
language
English
LU publication?
yes
id
97e8388a-98ff-4ee3-b30f-ef4b8292999d
date added to LUP
2022-04-14 11:36:41
date last changed
2024-06-20 01:49:49
@article{97e8388a-98ff-4ee3-b30f-ef4b8292999d,
  abstract     = {{<p>Current guidelines recommend flow cytometric analysis as part of the diagnostic assessment of patients with cytopenia suspected for myelodysplastic syndrome. Herein we describe the complete work-up of six cases using multimodal integrated diagnostics. Flow cytometry assessments are illustrated by plots from conventional and more recent analysis tools. The cases demonstrate the added value of flow cytometry in case of hypocellular, poor quality, or ambiguous bone marrow cytomorphology. Moreover, they demonstrate how immunophenotyping results support clinical decision-making in inconclusive and clinically ‘difficult’ cases.</p>}},
  author       = {{Westers, Theresia M. and Saft, Leonie and van der Velden, Vincent H.J. and te Marvelde, Jeroen G. and Dunlop, Alan and Ireland, Robin and Valent, Peter and Porwit, Anna and Béné, Marie C. and van de Loosdrecht, Arjan A.}},
  issn         = {{1552-4949}},
  keywords     = {{cytopenia; dysplasia; flow cytometry; integrated diagnostics; MDS}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{87--97}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Cytometry Part B - Clinical Cytometry}},
  title        = {{A series of case studies illustrating the role of flow cytometry in the diagnostic work-up of myelodysplastic syndromes}},
  url          = {{http://dx.doi.org/10.1002/cyto.b.22061}},
  doi          = {{10.1002/cyto.b.22061}},
  volume       = {{104}},
  year         = {{2023}},
}