A dual role of Cdk2 in DNA damage response
Satyanarayana, Ande and Kaldis, Philipp LU
(2009)
In Cell Division
4.
- Abstract
Once it was believed that Cdk2 was the master regulator of S phase entry. Gene knockout mouse studies of cell cycle regulators revealed that Cdk2 is dispensable for S phase initiation and progression whereby Cdk1 can compensate for the loss of Cdk2. Nevertheless, recent evidence indicates that Cdk2 is involved in cell cycle independent functions such as DNA damage repair. Whether these properties are unique to Cdk2 or also being compensated by other Cdks in the absence of Cdk2 is under extensive investigation. Here we review the emerging new role of Cdk2 in DNA damage repair and also discuss how the loss of Cdk2 impacts the G1/S phase DNA damage checkpoint.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/97fc40aa-f1d6-496a-a43d-73aa20961275
- author
- Satyanarayana, Ande
and Kaldis, Philipp
LU
- publishing date
- 2009-05-18
- type
- Contribution to journal
- publication status
- published
- in
- Cell Division
- volume
- 4
- article number
- 9
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:67449149014
- DOI
- 10.1186/1747-1028-4-9
- language
- English
- LU publication?
- no
- id
- 97fc40aa-f1d6-496a-a43d-73aa20961275
- date added to LUP
- 2019-09-18 14:10:19
- date last changed
- 2022-03-03 03:19:59
@article{97fc40aa-f1d6-496a-a43d-73aa20961275,
abstract = {{<p>Once it was believed that Cdk2 was the master regulator of S phase entry. Gene knockout mouse studies of cell cycle regulators revealed that Cdk2 is dispensable for S phase initiation and progression whereby Cdk1 can compensate for the loss of Cdk2. Nevertheless, recent evidence indicates that Cdk2 is involved in cell cycle independent functions such as DNA damage repair. Whether these properties are unique to Cdk2 or also being compensated by other Cdks in the absence of Cdk2 is under extensive investigation. Here we review the emerging new role of Cdk2 in DNA damage repair and also discuss how the loss of Cdk2 impacts the G1/S phase DNA damage checkpoint.</p>}},
author = {{Satyanarayana, Ande and Kaldis, Philipp}},
language = {{eng}},
month = {{05}},
publisher = {{BioMed Central (BMC)}},
series = {{Cell Division}},
title = {{A dual role of Cdk2 in DNA damage response}},
url = {{http://dx.doi.org/10.1186/1747-1028-4-9}},
doi = {{10.1186/1747-1028-4-9}},
volume = {{4}},
year = {{2009}},
}