Condensed Supramolecular Helices : The Twisted Sisters of DNA
Du, Guanqun LU ; Belić, Domagoj LU ; Del Giudice, Alessandra ; Alfredsson, Viveka LU ; Carnerup, Anna M. LU ; Zhu, Kaizheng ; Nyström, Bo ; Wang, Yilin ; Galantini, Luciano and Schillén, Karin LU
(2022)
In Angewandte Chemie (International edition)
61(4).
- Abstract
Condensation of DNA helices into hexagonally packed bundles and toroids represents an intriguing example of functional organization of biological macromolecules at the nanoscale. The condensation models are based on the unique polyelectrolyte features of DNA, however here we could reproduce a DNA-like condensation with supramolecular helices of small chiral molecules, thereby demonstrating that it is a more general phenomenon. We show that the bile salt sodium deoxycholate can form supramolecular helices upon interaction with oppositely charged polyelectrolytes of homopolymer or block copolymers. At higher order, a controlled hexagonal packing of the helices into DNA-like bundles and toroids could be accomplished. The results disclose... (More)
Condensation of DNA helices into hexagonally packed bundles and toroids represents an intriguing example of functional organization of biological macromolecules at the nanoscale. The condensation models are based on the unique polyelectrolyte features of DNA, however here we could reproduce a DNA-like condensation with supramolecular helices of small chiral molecules, thereby demonstrating that it is a more general phenomenon. We show that the bile salt sodium deoxycholate can form supramolecular helices upon interaction with oppositely charged polyelectrolytes of homopolymer or block copolymers. At higher order, a controlled hexagonal packing of the helices into DNA-like bundles and toroids could be accomplished. The results disclose unknown similarities between covalent and supramolecular non-covalent helical polyelectrolytes, which inspire visionary ideas of constructing supramolecular versions of biological macromolecules. As drug nanocarriers the polymer-bile salt superstructures would get advantage of a complex chirality at molecular and supramolecular levels, whose effect on the nanocarrier assisted drug efficiency is a still unexplored fascinating issue.
(Less)
- author
- Du, Guanqun
LU
; Belić, Domagoj
LU
; Del Giudice, Alessandra
; Alfredsson, Viveka
LU
; Carnerup, Anna M.
LU
; Zhu, Kaizheng
; Nyström, Bo
; Wang, Yilin
; Galantini, Luciano
and Schillén, Karin
LU
- organization
- publishing date
- 2022-01-21
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Angewandte Chemie (International edition)
- volume
- 61
- issue
- 4
- article number
- e202113279
- pages
- 9 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:34757695
- scopus:85120434560
- ISSN
- 1521-3773
- DOI
- 10.1002/anie.202113279
- language
- English
- LU publication?
- yes
- additional info
- © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
- id
- 9800c0d3-6968-4b6a-9c6a-9c4558029e5c
- date added to LUP
- 2021-12-13 22:46:02
- date last changed
- 2024-06-29 23:38:14
@article{9800c0d3-6968-4b6a-9c6a-9c4558029e5c,
abstract = {{<p>Condensation of DNA helices into hexagonally packed bundles and toroids represents an intriguing example of functional organization of biological macromolecules at the nanoscale. The condensation models are based on the unique polyelectrolyte features of DNA, however here we could reproduce a DNA-like condensation with supramolecular helices of small chiral molecules, thereby demonstrating that it is a more general phenomenon. We show that the bile salt sodium deoxycholate can form supramolecular helices upon interaction with oppositely charged polyelectrolytes of homopolymer or block copolymers. At higher order, a controlled hexagonal packing of the helices into DNA-like bundles and toroids could be accomplished. The results disclose unknown similarities between covalent and supramolecular non-covalent helical polyelectrolytes, which inspire visionary ideas of constructing supramolecular versions of biological macromolecules. As drug nanocarriers the polymer-bile salt superstructures would get advantage of a complex chirality at molecular and supramolecular levels, whose effect on the nanocarrier assisted drug efficiency is a still unexplored fascinating issue.</p>}},
author = {{Du, Guanqun and Belić, Domagoj and Del Giudice, Alessandra and Alfredsson, Viveka and Carnerup, Anna M. and Zhu, Kaizheng and Nyström, Bo and Wang, Yilin and Galantini, Luciano and Schillén, Karin}},
issn = {{1521-3773}},
language = {{eng}},
month = {{01}},
number = {{4}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Angewandte Chemie (International edition)}},
title = {{Condensed Supramolecular Helices : The Twisted Sisters of DNA}},
url = {{http://dx.doi.org/10.1002/anie.202113279}},
doi = {{10.1002/anie.202113279}},
volume = {{61}},
year = {{2022}},
}