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A longitudinal study of semantic memory impairment in patients with Alzheimer's disease

Mardh, Selina; Nägga, Katarina LU and Samuelsson, Stefan (2013) In Cortex 49(2). p.528-533
Abstract
Introduction: The present study explored the nature of the semantic deterioration normally displayed in the course of Alzheimer's disease (AD). The aim was to disentangle the extent to which semantic memory problems in patients with AD are best characterized as loss of semantic knowledge rather than difficulties in accessing semantic knowledge. Method: A longitudinal approach was applied. The same semantic-tests as well as same items were used across three test occasions a year apart. Twelve Alzheimer patients and 20 matched control subjects, out of a total of 25 cases in each group, remained at the final test occasion. Results and Conclusions: Alzheimer patients were impaired in all the semantic tasks as compared to the matched comparison... (More)
Introduction: The present study explored the nature of the semantic deterioration normally displayed in the course of Alzheimer's disease (AD). The aim was to disentangle the extent to which semantic memory problems in patients with AD are best characterized as loss of semantic knowledge rather than difficulties in accessing semantic knowledge. Method: A longitudinal approach was applied. The same semantic-tests as well as same items were used across three test occasions a year apart. Twelve Alzheimer patients and 20 matched control subjects, out of a total of 25 cases in each group, remained at the final test occasion. Results and Conclusions: Alzheimer patients were impaired in all the semantic tasks as compared to the matched comparison group. A progressing deterioration was evident during the study period. Our findings suggest that semantic impairment is mainly due to loss of information rather than problems in accessing semantic information. (C) 2012 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, Semantic memory impairment, Longitudinal study
in
Cortex
volume
49
issue
2
pages
528 - 533
publisher
Elsevier
external identifiers
  • wos:000316926800016
  • scopus:84875267066
ISSN
1973-8102
DOI
10.1016/j.cortex.2012.02.004
language
English
LU publication?
yes
id
981b6035-e076-4bd8-bfe4-b44da6d5835c (old id 3749469)
date added to LUP
2013-06-03 08:38:41
date last changed
2019-06-04 01:08:10
@article{981b6035-e076-4bd8-bfe4-b44da6d5835c,
  abstract     = {Introduction: The present study explored the nature of the semantic deterioration normally displayed in the course of Alzheimer's disease (AD). The aim was to disentangle the extent to which semantic memory problems in patients with AD are best characterized as loss of semantic knowledge rather than difficulties in accessing semantic knowledge. Method: A longitudinal approach was applied. The same semantic-tests as well as same items were used across three test occasions a year apart. Twelve Alzheimer patients and 20 matched control subjects, out of a total of 25 cases in each group, remained at the final test occasion. Results and Conclusions: Alzheimer patients were impaired in all the semantic tasks as compared to the matched comparison group. A progressing deterioration was evident during the study period. Our findings suggest that semantic impairment is mainly due to loss of information rather than problems in accessing semantic information. (C) 2012 Elsevier Ltd. All rights reserved.},
  author       = {Mardh, Selina and Nägga, Katarina and Samuelsson, Stefan},
  issn         = {1973-8102},
  keyword      = {Alzheimer's disease,Semantic memory impairment,Longitudinal study},
  language     = {eng},
  number       = {2},
  pages        = {528--533},
  publisher    = {Elsevier},
  series       = {Cortex},
  title        = {A longitudinal study of semantic memory impairment in patients with Alzheimer's disease},
  url          = {http://dx.doi.org/10.1016/j.cortex.2012.02.004},
  volume       = {49},
  year         = {2013},
}