Acute infection with the intestinal parasite Trichuris muris has long-term consequences on mucosal mast cell homeostasis and epithelial integrity
(2017) In European Journal of Immunology 47(2). p.257-268- Abstract
A hallmark of parasite infection is the accumulation of innate immune cells, notably granulocytes and mast cells, at the site of infection. While this is typically viewed as a transient response, with the tissue returning to steady state once the infection is cleared, we found that mast cells accumulated in the large-intestinal epithelium following infection with the nematode Trichuris muris and persisted at this site for several months after worm expulsion. Mast cell accumulation in the epithelium was associated with the induction of type-2 immunity and appeared to be driven by increased maturation of local progenitors in the intestinal lamina propria. Furthermore, we also detected increased local and systemic levels of the mucosal... (More)
A hallmark of parasite infection is the accumulation of innate immune cells, notably granulocytes and mast cells, at the site of infection. While this is typically viewed as a transient response, with the tissue returning to steady state once the infection is cleared, we found that mast cells accumulated in the large-intestinal epithelium following infection with the nematode Trichuris muris and persisted at this site for several months after worm expulsion. Mast cell accumulation in the epithelium was associated with the induction of type-2 immunity and appeared to be driven by increased maturation of local progenitors in the intestinal lamina propria. Furthermore, we also detected increased local and systemic levels of the mucosal mast cell protease MCPt-1, which correlated highly with the persistent epithelial mast cell population. Finally, the mast cells appeared to have striking consequences on epithelial barrier integrity, by regulation of gut permeability long after worm expulsion. These findings highlight the importance of mast cells not only in the early phases of infection but also at later stages, which has functional implications on the mucosal tissue.
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- author
- Sorobetea, Daniel LU ; Holm, Jacob Bak ; Henningsson, Henrietta LU ; Kristiansen, Karsten and Svensson-Frej, Marcus LU
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acute parasite infection, Large-intestinal epithelium, MCPt-1, Mucosal mast cell, Trichuris muris
- in
- European Journal of Immunology
- volume
- 47
- issue
- 2
- pages
- 257 - 268
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85009168186
- pmid:27891580
- wos:000394839800007
- ISSN
- 0014-2980
- DOI
- 10.1002/eji.201646738
- language
- English
- LU publication?
- yes
- id
- 9838cbfc-9612-4c1c-b148-97be645c13ec
- date added to LUP
- 2017-02-10 14:41:24
- date last changed
- 2024-06-24 14:29:04
@article{9838cbfc-9612-4c1c-b148-97be645c13ec,
abstract = {{<p>A hallmark of parasite infection is the accumulation of innate immune cells, notably granulocytes and mast cells, at the site of infection. While this is typically viewed as a transient response, with the tissue returning to steady state once the infection is cleared, we found that mast cells accumulated in the large-intestinal epithelium following infection with the nematode Trichuris muris and persisted at this site for several months after worm expulsion. Mast cell accumulation in the epithelium was associated with the induction of type-2 immunity and appeared to be driven by increased maturation of local progenitors in the intestinal lamina propria. Furthermore, we also detected increased local and systemic levels of the mucosal mast cell protease MCPt-1, which correlated highly with the persistent epithelial mast cell population. Finally, the mast cells appeared to have striking consequences on epithelial barrier integrity, by regulation of gut permeability long after worm expulsion. These findings highlight the importance of mast cells not only in the early phases of infection but also at later stages, which has functional implications on the mucosal tissue.</p>}},
author = {{Sorobetea, Daniel and Holm, Jacob Bak and Henningsson, Henrietta and Kristiansen, Karsten and Svensson-Frej, Marcus}},
issn = {{0014-2980}},
keywords = {{Acute parasite infection; Large-intestinal epithelium; MCPt-1; Mucosal mast cell; Trichuris muris}},
language = {{eng}},
number = {{2}},
pages = {{257--268}},
publisher = {{John Wiley & Sons Inc.}},
series = {{European Journal of Immunology}},
title = {{Acute infection with the intestinal parasite Trichuris muris has long-term consequences on mucosal mast cell homeostasis and epithelial integrity}},
url = {{https://lup.lub.lu.se/search/files/28760755/21274224.pdf}},
doi = {{10.1002/eji.201646738}},
volume = {{47}},
year = {{2017}},
}