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Acute infection with the intestinal parasite Trichuris muris has long-term consequences on mucosal mast cell homeostasis and epithelial integrity

Sorobetea, Daniel LU ; Holm, Jacob Bak; Henningsson, Henrietta LU ; Kristiansen, Karsten and Svensson-Frej, Marcus LU (2017) In European Journal of Immunology 47(2). p.257-268
Abstract

A hallmark of parasite infection is the accumulation of innate immune cells, notably granulocytes and mast cells, at the site of infection. While this is typically viewed as a transient response, with the tissue returning to steady state once the infection is cleared, we found that mast cells accumulated in the large-intestinal epithelium following infection with the nematode Trichuris muris and persisted at this site for several months after worm expulsion. Mast cell accumulation in the epithelium was associated with the induction of type-2 immunity and appeared to be driven by increased maturation of local progenitors in the intestinal lamina propria. Furthermore, we also detected increased local and systemic levels of the mucosal... (More)

A hallmark of parasite infection is the accumulation of innate immune cells, notably granulocytes and mast cells, at the site of infection. While this is typically viewed as a transient response, with the tissue returning to steady state once the infection is cleared, we found that mast cells accumulated in the large-intestinal epithelium following infection with the nematode Trichuris muris and persisted at this site for several months after worm expulsion. Mast cell accumulation in the epithelium was associated with the induction of type-2 immunity and appeared to be driven by increased maturation of local progenitors in the intestinal lamina propria. Furthermore, we also detected increased local and systemic levels of the mucosal mast cell protease MCPt-1, which correlated highly with the persistent epithelial mast cell population. Finally, the mast cells appeared to have striking consequences on epithelial barrier integrity, by regulation of gut permeability long after worm expulsion. These findings highlight the importance of mast cells not only in the early phases of infection but also at later stages, which has functional implications on the mucosal tissue.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acute parasite infection, Large-intestinal epithelium, MCPt-1, Mucosal mast cell, Trichuris muris
in
European Journal of Immunology
volume
47
issue
2
pages
257 - 268
publisher
John Wiley & Sons
external identifiers
  • scopus:85009168186
  • wos:000394839800007
ISSN
0014-2980
DOI
10.1002/eji.201646738
language
English
LU publication?
yes
id
9838cbfc-9612-4c1c-b148-97be645c13ec
date added to LUP
2017-02-10 14:41:24
date last changed
2018-05-06 04:30:43
@article{9838cbfc-9612-4c1c-b148-97be645c13ec,
  abstract     = {<p>A hallmark of parasite infection is the accumulation of innate immune cells, notably granulocytes and mast cells, at the site of infection. While this is typically viewed as a transient response, with the tissue returning to steady state once the infection is cleared, we found that mast cells accumulated in the large-intestinal epithelium following infection with the nematode Trichuris muris and persisted at this site for several months after worm expulsion. Mast cell accumulation in the epithelium was associated with the induction of type-2 immunity and appeared to be driven by increased maturation of local progenitors in the intestinal lamina propria. Furthermore, we also detected increased local and systemic levels of the mucosal mast cell protease MCPt-1, which correlated highly with the persistent epithelial mast cell population. Finally, the mast cells appeared to have striking consequences on epithelial barrier integrity, by regulation of gut permeability long after worm expulsion. These findings highlight the importance of mast cells not only in the early phases of infection but also at later stages, which has functional implications on the mucosal tissue.</p>},
  author       = {Sorobetea, Daniel and Holm, Jacob Bak and Henningsson, Henrietta and Kristiansen, Karsten and Svensson-Frej, Marcus},
  issn         = {0014-2980},
  keyword      = {Acute parasite infection,Large-intestinal epithelium,MCPt-1,Mucosal mast cell,Trichuris muris},
  language     = {eng},
  number       = {2},
  pages        = {257--268},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Immunology},
  title        = {Acute infection with the intestinal parasite Trichuris muris has long-term consequences on mucosal mast cell homeostasis and epithelial integrity},
  url          = {http://dx.doi.org/10.1002/eji.201646738},
  volume       = {47},
  year         = {2017},
}