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High need for intensive care in paediatric acute myeloid leukaemia : A population-based study

Ranta, Susanna ; Broman, Lars Mikael ; Abrahamsson, Jonas ; Karlsson, Lene ; Norén-Nyström, Ulrika ; Palle, Josefine ; Svahn, Johan E. LU ; Törnudd, Lisa ; Heyman, Mats and Harila-Saari, Arja (2022) In Acta Paediatrica, International Journal of Paediatrics 111(11). p.2235-2241
Abstract

Aim: Risk of treatment-related life-threatening toxicity is high in childhood acute myeloid leukaemia (AML), and access to intensive care units (ICU) is crucial. We explored the ICU admission rate and outcome after intensive care in childhood AML in Sweden. Methods: Patients diagnosed between 2008 and 2016 were identified from the Swedish Childhood Cancer Registry (SCCR), a national quality registry. Data from SCCR was cross-referenced with clinical questionnaire data from paediatric oncology centers and the Swedish Intensive Care Registry (SIR), another national quality registry. Results: According to combined data, 46% of the children (58/126) were admitted to ICU, 17% (21/126) within 1 month from diagnosis. Overall, ICU mortality per... (More)

Aim: Risk of treatment-related life-threatening toxicity is high in childhood acute myeloid leukaemia (AML), and access to intensive care units (ICU) is crucial. We explored the ICU admission rate and outcome after intensive care in childhood AML in Sweden. Methods: Patients diagnosed between 2008 and 2016 were identified from the Swedish Childhood Cancer Registry (SCCR), a national quality registry. Data from SCCR was cross-referenced with clinical questionnaire data from paediatric oncology centers and the Swedish Intensive Care Registry (SIR), another national quality registry. Results: According to combined data, 46% of the children (58/126) were admitted to ICU, 17% (21/126) within 1 month from diagnosis. Overall, ICU mortality per admission was 12% and 6% during first-line treatment. There was a discrepancy between admission rate from the clinical questionnaires and SCCR (29%; 36/126 children) and SIR (44%; 55/126) All deaths during first-line treatment occurred at or after ICU care. Conclusion: Although admission rate under AML treatment was high, the treatment-related mortality under first-line treatment was low. No child died under first-line treatment without admission to ICU, suggesting good availability. The discrepancy between the two registries, SCCR and SIR, highlights the need for future validation of registry data.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
AML, children, incidence, intensive care
in
Acta Paediatrica, International Journal of Paediatrics
volume
111
issue
11
pages
2235 - 2241
publisher
Wiley-Blackwell
external identifiers
  • pmid:35869573
  • scopus:85135136864
ISSN
0803-5253
DOI
10.1111/apa.16497
language
English
LU publication?
yes
id
987b40b8-dc85-4177-b6ca-341b232fb6d8
date added to LUP
2022-10-11 11:27:02
date last changed
2024-11-15 07:50:18
@article{987b40b8-dc85-4177-b6ca-341b232fb6d8,
  abstract     = {{<p>Aim: Risk of treatment-related life-threatening toxicity is high in childhood acute myeloid leukaemia (AML), and access to intensive care units (ICU) is crucial. We explored the ICU admission rate and outcome after intensive care in childhood AML in Sweden. Methods: Patients diagnosed between 2008 and 2016 were identified from the Swedish Childhood Cancer Registry (SCCR), a national quality registry. Data from SCCR was cross-referenced with clinical questionnaire data from paediatric oncology centers and the Swedish Intensive Care Registry (SIR), another national quality registry. Results: According to combined data, 46% of the children (58/126) were admitted to ICU, 17% (21/126) within 1 month from diagnosis. Overall, ICU mortality per admission was 12% and 6% during first-line treatment. There was a discrepancy between admission rate from the clinical questionnaires and SCCR (29%; 36/126 children) and SIR (44%; 55/126) All deaths during first-line treatment occurred at or after ICU care. Conclusion: Although admission rate under AML treatment was high, the treatment-related mortality under first-line treatment was low. No child died under first-line treatment without admission to ICU, suggesting good availability. The discrepancy between the two registries, SCCR and SIR, highlights the need for future validation of registry data.</p>}},
  author       = {{Ranta, Susanna and Broman, Lars Mikael and Abrahamsson, Jonas and Karlsson, Lene and Norén-Nyström, Ulrika and Palle, Josefine and Svahn, Johan E. and Törnudd, Lisa and Heyman, Mats and Harila-Saari, Arja}},
  issn         = {{0803-5253}},
  keywords     = {{AML; children; incidence; intensive care}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{2235--2241}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Paediatrica, International Journal of Paediatrics}},
  title        = {{High need for intensive care in paediatric acute myeloid leukaemia : A population-based study}},
  url          = {{http://dx.doi.org/10.1111/apa.16497}},
  doi          = {{10.1111/apa.16497}},
  volume       = {{111}},
  year         = {{2022}},
}