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Oscillations in coupled enzymic reactions at high concentration of enzyme

Ryde-Pettersson, Ulf LU (1992) In Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology 1119(2). p.118-122
Abstract

The transient-state kinetic consequences of the coupling of a single-enzyme reaction to other metabolic reactions have been examined in generalized terms. Analytical data are presented which specify under what conditions such coupling may lead to an oscillatory transient rate behaviour of a reaction system involving an enzyme operating by a Michaelian mechanism. The results indicate that the presence of enzyme in concentrations comparable to those of substrate and product may represent a hitherto unforeseen possible source of weakly damped, or even sustained, oscillations in metabolic networks. This observation has some important implications with regard to the occurrence of oscillations in biochemical reaction systems and to... (More)

The transient-state kinetic consequences of the coupling of a single-enzyme reaction to other metabolic reactions have been examined in generalized terms. Analytical data are presented which specify under what conditions such coupling may lead to an oscillatory transient rate behaviour of a reaction system involving an enzyme operating by a Michaelian mechanism. The results indicate that the presence of enzyme in concentrations comparable to those of substrate and product may represent a hitherto unforeseen possible source of weakly damped, or even sustained, oscillations in metabolic networks. This observation has some important implications with regard to the occurrence of oscillations in biochemical reaction systems and to transient-state kinetic modelling of metabolic systems. © 1992.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
End-product inhibition, High enzyme concentration, Metabolic oscillation, Ribulose 1,5-bisphosphate carboxylase, Steady-state approximation
in
Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology
volume
1119
issue
2
pages
5 pages
publisher
Elsevier
external identifiers
  • scopus:0026529511
ISSN
0167-4838
DOI
10.1016/0167-4838(92)90380-V
language
English
LU publication?
yes
id
98ac949e-b4da-4481-a3ec-045a27221487
date added to LUP
2017-02-04 11:16:57
date last changed
2017-03-06 16:18:30
@article{98ac949e-b4da-4481-a3ec-045a27221487,
  abstract     = {<p>The transient-state kinetic consequences of the coupling of a single-enzyme reaction to other metabolic reactions have been examined in generalized terms. Analytical data are presented which specify under what conditions such coupling may lead to an oscillatory transient rate behaviour of a reaction system involving an enzyme operating by a Michaelian mechanism. The results indicate that the presence of enzyme in concentrations comparable to those of substrate and product may represent a hitherto unforeseen possible source of weakly damped, or even sustained, oscillations in metabolic networks. This observation has some important implications with regard to the occurrence of oscillations in biochemical reaction systems and to transient-state kinetic modelling of metabolic systems. © 1992.</p>},
  author       = {Ryde-Pettersson, Ulf},
  issn         = {0167-4838},
  keyword      = {End-product inhibition,High enzyme concentration,Metabolic oscillation,Ribulose 1,5-bisphosphate carboxylase,Steady-state approximation},
  language     = {eng},
  month        = {02},
  number       = {2},
  pages        = {118--122},
  publisher    = {Elsevier},
  series       = {Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology},
  title        = {Oscillations in coupled enzymic reactions at high concentration of enzyme},
  url          = {http://dx.doi.org/10.1016/0167-4838(92)90380-V},
  volume       = {1119},
  year         = {1992},
}