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Swedish Chronic Pain Biobank : Protocol for a multicentre registry and biomarker project

Ghafouri, Bijar ; Ernberg, Malin ; Andréll, Paulin ; Bäckryd, Emmanuel ; Fisher, Marcelo Rivano LU ; Freund-Levi, Yvonne ; Grelz, Henrik LU orcid ; Gräbel, Olaf ; Karlsten, Rolf and Kosek, Eva , et al. (2022) In BMJ Open 12(11).
Abstract

Introduction About 20% of the adult population have chronic pain, often associated with psychological distress, sick leave and poor health. There are large variations in the clinical picture. A biopsychosocial approach is used in investigation and treatment. The concept of personalised medicine, that is, optimising medication types and dosages for individual patients based on biomarkers and other patient-related factors, has received increasing attention in different diseases but used less in chronic pain. This cooperative project from all Swedish University Hospitals will investigate whether there are changes in inflammation and metabolism patterns in saliva and blood in chronic pain patients and whether the changes correlate with... (More)

Introduction About 20% of the adult population have chronic pain, often associated with psychological distress, sick leave and poor health. There are large variations in the clinical picture. A biopsychosocial approach is used in investigation and treatment. The concept of personalised medicine, that is, optimising medication types and dosages for individual patients based on biomarkers and other patient-related factors, has received increasing attention in different diseases but used less in chronic pain. This cooperative project from all Swedish University Hospitals will investigate whether there are changes in inflammation and metabolism patterns in saliva and blood in chronic pain patients and whether the changes correlate with clinical characteristics and rehabilitation outcomes. Methods and analysis Patients at multidisciplinary pain centres at University Hospitals in Sweden who have chosen to participate in the Swedish Quality Registry for Pain Rehabilitation and healthy sex-matched and age-matched individuals will be included in the study. Saliva and blood samples will be collected in addition to questionnaire data obtained from the register. From the samples, proteins, lipids, metabolites and micro-RNA will be analysed in relation to, for example, diagnosis, pain characteristics, psychological distress, body weight, pharmacological treatment and clinical rehabilitation results using advanced multivariate data analysis and bioinformatics. Ethics and dissemination The study is approved by the Swedish Ethical Review Authority (Dnr 2021-04929) and will be conducted in accordance with the declaration of Helsinki. The results will be published in open access scientific journals and in popular scientific relevant journals such as those from patient organisations. Data will be also presented in scientific meetings, meeting with healthcare organisations and disseminated in different lecturers at the clinics and universities.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
back pain, neurological pain, pain management, rehabilitation medicine
in
BMJ Open
volume
12
issue
11
article number
e066834
publisher
BMJ Publishing Group
external identifiers
  • scopus:85143108937
  • pmid:36450421
ISSN
2044-6055
DOI
10.1136/bmjopen-2022-066834
language
English
LU publication?
yes
id
98c07649-04d6-4306-8358-bc96336586ab
date added to LUP
2022-12-23 09:42:32
date last changed
2024-05-28 22:46:49
@article{98c07649-04d6-4306-8358-bc96336586ab,
  abstract     = {{<p>Introduction About 20% of the adult population have chronic pain, often associated with psychological distress, sick leave and poor health. There are large variations in the clinical picture. A biopsychosocial approach is used in investigation and treatment. The concept of personalised medicine, that is, optimising medication types and dosages for individual patients based on biomarkers and other patient-related factors, has received increasing attention in different diseases but used less in chronic pain. This cooperative project from all Swedish University Hospitals will investigate whether there are changes in inflammation and metabolism patterns in saliva and blood in chronic pain patients and whether the changes correlate with clinical characteristics and rehabilitation outcomes. Methods and analysis Patients at multidisciplinary pain centres at University Hospitals in Sweden who have chosen to participate in the Swedish Quality Registry for Pain Rehabilitation and healthy sex-matched and age-matched individuals will be included in the study. Saliva and blood samples will be collected in addition to questionnaire data obtained from the register. From the samples, proteins, lipids, metabolites and micro-RNA will be analysed in relation to, for example, diagnosis, pain characteristics, psychological distress, body weight, pharmacological treatment and clinical rehabilitation results using advanced multivariate data analysis and bioinformatics. Ethics and dissemination The study is approved by the Swedish Ethical Review Authority (Dnr 2021-04929) and will be conducted in accordance with the declaration of Helsinki. The results will be published in open access scientific journals and in popular scientific relevant journals such as those from patient organisations. Data will be also presented in scientific meetings, meeting with healthcare organisations and disseminated in different lecturers at the clinics and universities.</p>}},
  author       = {{Ghafouri, Bijar and Ernberg, Malin and Andréll, Paulin and Bäckryd, Emmanuel and Fisher, Marcelo Rivano and Freund-Levi, Yvonne and Grelz, Henrik and Gräbel, Olaf and Karlsten, Rolf and Kosek, Eva and Löfgren, Monika and Ringqvist, Åsa and Rudling, Karin and Stålnacke, Britt Marie and Sörlén, Niklas and Uhlin, Karin and Westergren, Hans and Gerdle, Björn}},
  issn         = {{2044-6055}},
  keywords     = {{back pain; neurological pain; pain management; rehabilitation medicine}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{11}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{BMJ Open}},
  title        = {{Swedish Chronic Pain Biobank : Protocol for a multicentre registry and biomarker project}},
  url          = {{http://dx.doi.org/10.1136/bmjopen-2022-066834}},
  doi          = {{10.1136/bmjopen-2022-066834}},
  volume       = {{12}},
  year         = {{2022}},
}