Analysis of Endotoxin Adsorption in Two Swedish Patients with Septic Shock
(2019) In Blood Purification 47. p.1-3- Abstract
BACKGROUND: Lipopolysaccharide (endotoxin) from the outer Gram-negative bacterial wall can induce a harmful immunologic response, involving hemodynamic deprivation, and is one important motor driving the septic cascade. The positively charged poly-imine ethylene layer on the oXiris membrane is capable of adsorbing negatively charged endotoxin molecules and removing them from the blood compartment. Endotoxin is detrimental and should be removed from blood. SUMMARY: The adsorbable endotoxin fraction in blood arises from a tight balance between seeding from an infectious focus and removal by an overwhelmed immune system. The net sum of remaining endotoxin in blood is available for an adsorption process in the oXiris filter. Endotoxin data... (More)
BACKGROUND: Lipopolysaccharide (endotoxin) from the outer Gram-negative bacterial wall can induce a harmful immunologic response, involving hemodynamic deprivation, and is one important motor driving the septic cascade. The positively charged poly-imine ethylene layer on the oXiris membrane is capable of adsorbing negatively charged endotoxin molecules and removing them from the blood compartment. Endotoxin is detrimental and should be removed from blood. SUMMARY: The adsorbable endotoxin fraction in blood arises from a tight balance between seeding from an infectious focus and removal by an overwhelmed immune system. The net sum of remaining endotoxin in blood is available for an adsorption process in the oXiris filter. Endotoxin data from 2 patients with severe Gram-negative septic shock and endotoxemia in this case series, speaks for a considerable share of the adsorption of the oXiris filter in the endotoxin net removal over time. Key Messages: Analysis of combined in vitro and in vivo data speaks for an effect of the oXiris filter in lowering endotoxin.
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- author
- Broman, Marcus Ewert LU and Bodelsson, Mikael LU
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acute kidney injury, Endotoxin, Sepsis
- in
- Blood Purification
- volume
- 47
- pages
- 1 - 3
- publisher
- Karger
- external identifiers
-
- scopus:85064962618
- pmid:30982027
- ISSN
- 0253-5068
- DOI
- 10.1159/000499546
- language
- English
- LU publication?
- no
- id
- 98c9b524-ffaf-4ac4-9d9e-48159017f0e6
- date added to LUP
- 2019-05-17 12:29:28
- date last changed
- 2024-04-16 05:59:43
@article{98c9b524-ffaf-4ac4-9d9e-48159017f0e6,
abstract = {{<p>BACKGROUND: Lipopolysaccharide (endotoxin) from the outer Gram-negative bacterial wall can induce a harmful immunologic response, involving hemodynamic deprivation, and is one important motor driving the septic cascade. The positively charged poly-imine ethylene layer on the oXiris membrane is capable of adsorbing negatively charged endotoxin molecules and removing them from the blood compartment. Endotoxin is detrimental and should be removed from blood. SUMMARY: The adsorbable endotoxin fraction in blood arises from a tight balance between seeding from an infectious focus and removal by an overwhelmed immune system. The net sum of remaining endotoxin in blood is available for an adsorption process in the oXiris filter. Endotoxin data from 2 patients with severe Gram-negative septic shock and endotoxemia in this case series, speaks for a considerable share of the adsorption of the oXiris filter in the endotoxin net removal over time. Key Messages: Analysis of combined in vitro and in vivo data speaks for an effect of the oXiris filter in lowering endotoxin.</p>}},
author = {{Broman, Marcus Ewert and Bodelsson, Mikael}},
issn = {{0253-5068}},
keywords = {{Acute kidney injury; Endotoxin; Sepsis}},
language = {{eng}},
pages = {{1--3}},
publisher = {{Karger}},
series = {{Blood Purification}},
title = {{Analysis of Endotoxin Adsorption in Two Swedish Patients with Septic Shock}},
url = {{http://dx.doi.org/10.1159/000499546}},
doi = {{10.1159/000499546}},
volume = {{47}},
year = {{2019}},
}