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On the influence of heart rate and coupling interval prematurity on heart rate turbulence

Barquero-Perez, Oscar; Figuera, Carlos; Goya-Esteban, Rebeca; Mora-Jimenez, Inmaculada; Gimeno-Blanes, Francisco Javier; Laguna, Pablo; Martinez, Juan Pablo; Gil, Eduardo; Sornmo, Leif LU and Garcia-Alberola, Arcadi, et al. (2017) In IEEE Transactions on Biomedical Engineering 64(2). p.302-309
Abstract

Objective: Heart rate turbulence (HRT) has been successfully explored for cardiac risk stratification. While HRT is known to be influenced by the heart rate (HR) and the coupling interval (CI), nonconcordant results have been reported on how the CI influences HRT. The purpose of this study is to investigate HRT changes in terms of CI and HR by means of an especially designed protocol. Methods: A dataset was acquired from 11 patients with structurally normal hearts for which CI was altered by different pacing trains and HR by isoproterenol during electrophysiological study (EPS). The protocol was designed so that, first, the effect of HR changes on HRT and, second, the combined effect of HR and CI could be explored. As a complement to... (More)

Objective: Heart rate turbulence (HRT) has been successfully explored for cardiac risk stratification. While HRT is known to be influenced by the heart rate (HR) and the coupling interval (CI), nonconcordant results have been reported on how the CI influences HRT. The purpose of this study is to investigate HRT changes in terms of CI and HR by means of an especially designed protocol. Methods: A dataset was acquired from 11 patients with structurally normal hearts for which CI was altered by different pacing trains and HR by isoproterenol during electrophysiological study (EPS). The protocol was designed so that, first, the effect of HR changes on HRT and, second, the combined effect of HR and CI could be explored. As a complement to the EPS dataset, a database of 24-h Holters from 61 acute myocardial infarction (AMI) patients was studied for the purpose of assessing risk. Data analysis was performed by using different nonlinear ridge regression models, and the relevance of model variables was assessed using resampling methods. The EPS subjects, with and without isoproterenol, were analyzed separately. Results: The proposed nonlinear regression models were found to account for the influence of HR and CI on HRT, both in patients undergoing EPS without isoproterenol and in low-risk AMI patients, whereas this influence was absent in high-risk AMI patients. Moreover, model coefficients related to CI were not statistically significant, p > 0.05, on EPS subjects with isoproterenol. Conclusion: The observed relationship between CI and HRT, being in agreement with the baroreflex hypothesis, was statistically significant (p < 0.05), when decoupling the effect of HR and normalizing the CI by the HR. Significance: The results of this study can help to provide new risk indicators that take into account physiological influence on HRT, as well as to model how this influence changes in different cardiac conditions.

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keywords
Coupling interval, electrophysiological study, heart rate, heart rate turbulence, myocardial infarction
in
IEEE Transactions on Biomedical Engineering
volume
64
issue
2
pages
8 pages
publisher
IEEE--Institute of Electrical and Electronics Engineers Inc.
external identifiers
  • scopus:85014967101
  • wos:000394686900006
ISSN
0018-9294
DOI
10.1109/TBME.2016.2554614
language
English
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yes
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994e3161-3055-4d68-bf42-e149f49d3963
date added to LUP
2017-03-23 10:41:52
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2018-01-07 11:56:51
@article{994e3161-3055-4d68-bf42-e149f49d3963,
  abstract     = {<p>Objective: Heart rate turbulence (HRT) has been successfully explored for cardiac risk stratification. While HRT is known to be influenced by the heart rate (HR) and the coupling interval (CI), nonconcordant results have been reported on how the CI influences HRT. The purpose of this study is to investigate HRT changes in terms of CI and HR by means of an especially designed protocol. Methods: A dataset was acquired from 11 patients with structurally normal hearts for which CI was altered by different pacing trains and HR by isoproterenol during electrophysiological study (EPS). The protocol was designed so that, first, the effect of HR changes on HRT and, second, the combined effect of HR and CI could be explored. As a complement to the EPS dataset, a database of 24-h Holters from 61 acute myocardial infarction (AMI) patients was studied for the purpose of assessing risk. Data analysis was performed by using different nonlinear ridge regression models, and the relevance of model variables was assessed using resampling methods. The EPS subjects, with and without isoproterenol, were analyzed separately. Results: The proposed nonlinear regression models were found to account for the influence of HR and CI on HRT, both in patients undergoing EPS without isoproterenol and in low-risk AMI patients, whereas this influence was absent in high-risk AMI patients. Moreover, model coefficients related to CI were not statistically significant, p &gt; 0.05, on EPS subjects with isoproterenol. Conclusion: The observed relationship between CI and HRT, being in agreement with the baroreflex hypothesis, was statistically significant (p &lt; 0.05), when decoupling the effect of HR and normalizing the CI by the HR. Significance: The results of this study can help to provide new risk indicators that take into account physiological influence on HRT, as well as to model how this influence changes in different cardiac conditions.</p>},
  articleno    = {7453140},
  author       = {Barquero-Perez, Oscar and Figuera, Carlos and Goya-Esteban, Rebeca and Mora-Jimenez, Inmaculada and Gimeno-Blanes, Francisco Javier and Laguna, Pablo and Martinez, Juan Pablo and Gil, Eduardo and Sornmo, Leif and Garcia-Alberola, Arcadi and Rojo-Alvarez, Jose Luis},
  issn         = {0018-9294},
  keyword      = {Coupling interval,electrophysiological study,heart rate,heart rate turbulence,myocardial infarction},
  language     = {eng},
  month        = {02},
  number       = {2},
  pages        = {302--309},
  publisher    = {IEEE--Institute of Electrical and Electronics Engineers Inc.},
  series       = {IEEE Transactions on Biomedical Engineering},
  title        = {On the influence of heart rate and coupling interval prematurity on heart rate turbulence},
  url          = {http://dx.doi.org/10.1109/TBME.2016.2554614},
  volume       = {64},
  year         = {2017},
}