Actions of platelet-activating factor on isolated feline and human cerebral arteries
(1990) In Journal of Cerebral Blood Flow and Metabolism 10(3). p.428-431- Abstract
- The effects of platelet-activating factor (PAF) were studied on isolated feline basilar arteries (BAs) and human pial arteries (PAs). PAF contracted the BAs by 67% of the contraction induced by 124 mM K+ and the PAs by 80%. The contraction in BAs was unaffected by both indomethacin and the thromboxane receptor antagonist AH23848. PAF relaxed prostaglandin F2 alpha-contracted arteries. In BAs 10(-6) M PAF reduced the contraction by 17% and in PAs by 47%. The relaxant effects in both arteries were unaffected by indomethacin. In conclusion, PAF can act both as a constrictor and as a dilator of isolated feline and human cerebral arteries. The effects are seemingly unrelated to vascular prostanoid production.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1105159
- author
- Uski, Tore LU and Reinstrup, Peter LU
- organization
- publishing date
- 1990
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Cerebral Blood Flow and Metabolism
- volume
- 10
- issue
- 3
- pages
- 428 - 431
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:2329129
- scopus:0025228442
- ISSN
- 1559-7016
- language
- English
- LU publication?
- yes
- id
- 995303ba-8db7-456e-84e5-4179dd0c6770 (old id 1105159)
- date added to LUP
- 2016-04-01 16:09:29
- date last changed
- 2021-09-19 05:33:58
@article{995303ba-8db7-456e-84e5-4179dd0c6770, abstract = {{The effects of platelet-activating factor (PAF) were studied on isolated feline basilar arteries (BAs) and human pial arteries (PAs). PAF contracted the BAs by 67% of the contraction induced by 124 mM K+ and the PAs by 80%. The contraction in BAs was unaffected by both indomethacin and the thromboxane receptor antagonist AH23848. PAF relaxed prostaglandin F2 alpha-contracted arteries. In BAs 10(-6) M PAF reduced the contraction by 17% and in PAs by 47%. The relaxant effects in both arteries were unaffected by indomethacin. In conclusion, PAF can act both as a constrictor and as a dilator of isolated feline and human cerebral arteries. The effects are seemingly unrelated to vascular prostanoid production.}}, author = {{Uski, Tore and Reinstrup, Peter}}, issn = {{1559-7016}}, language = {{eng}}, number = {{3}}, pages = {{428--431}}, publisher = {{Nature Publishing Group}}, series = {{Journal of Cerebral Blood Flow and Metabolism}}, title = {{Actions of platelet-activating factor on isolated feline and human cerebral arteries}}, volume = {{10}}, year = {{1990}}, }