Cardiovascular effects of intrauterine exposure to maternal HIV and antiretroviral therapy in Ethiopian infants followed from fetal life
García-Otero, Laura ; Walles, John LU
; Balcha, Taye Tolera
LU
; Merga, Gadissa
LU
; López, Marta
; Crispi, Fatima
and Björkman, Per
LU
(2022)
In AIDS
36(7).
p.941-951
- Abstract
Objective:To assess cardiovascular effects of in-utero HIV and antiretroviral treatment (ART) exposure on offspring of HIV-positive mothers in Ethiopia.Design:HIV-positive and HIV-negative pregnancies were identified from a prospective cohort of women recruited at their first antenatal care visit in Ethiopia, using a nested case-control design.Methods:Fetal standard ultrasound and echocardiography were performed at 2237 weeks of pregnancy to assess fetal biometry and cardiac structure. Postnatal cardiovascular evaluation, including echocardiography and vascular assessment, was performed at 6 months of age. Cardiovascular data were correlated to HIV serostatus, antiretroviral drug exposure and HIV-unrelated maternal... (More)
Objective:To assess cardiovascular effects of in-utero HIV and antiretroviral treatment (ART) exposure on offspring of HIV-positive mothers in Ethiopia.Design:HIV-positive and HIV-negative pregnancies were identified from a prospective cohort of women recruited at their first antenatal care visit in Ethiopia, using a nested case-control design.Methods:Fetal standard ultrasound and echocardiography were performed at 2237 weeks of pregnancy to assess fetal biometry and cardiac structure. Postnatal cardiovascular evaluation, including echocardiography and vascular assessment, was performed at 6 months of age. Cardiovascular data were correlated to HIV serostatus, antiretroviral drug exposure and HIV-unrelated maternal characteristics.Results:Fetuses from 29 HIV-positive and 67 HIV-negative women paired by gestational age at scan were included. Among HIV-positive women, 25 were on ART before conception, and 4 initiated ART during pregnancy. Estimated fetal weight was similar in both groups [mean 1873 g (standard deviation; SD 569) vs. 1839 g (SD 579) P = 0.79, respectively]. Fetal cardiac morphometry was similar with regard to maternal HIV serostatus: cardiothoracic ratio mean 0.26 (SD 0.05) vs. 0.25 (SD 0.06), P = 0.48; and septal wall thickness mean 4.03 mm (SD 0.58) vs. 3.98 mm (SD 0.70), P = 0.94. No significant cardiovascular differences were detected postnatally according to maternal HIV serostatus: septal wall thickness mean 5.46 mm (SD 0.65) vs. 5.49 (SD 0.89); P = 0.896; isovolumic relaxation time 55.08 ms (SD 6.57) vs. 56.56 (SD 6.74); P = 0.359.Conclusion:In offspring of Ethiopian women, intrauterine exposure to HIV and ART were not associated with cardiovascular changes from fetal life up to infanthood.
(Less)
- author
- García-Otero, Laura
; Walles, John
LU
; Balcha, Taye Tolera
LU
; Merga, Gadissa
LU
; López, Marta
; Crispi, Fatima
and Björkman, Per
LU
- organization
- publishing date
- 2022-06-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Antiretroviral therapy, cardiac, echocardiography, fetal heart, HIV, sub-Saharan Africa
- in
- AIDS
- volume
- 36
- issue
- 7
- pages
- 11 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:85131270545
- pmid:35142707
- ISSN
- 0269-9370
- DOI
- 10.1097/QAD.0000000000003188
- language
- English
- LU publication?
- yes
- id
- 9985a8fe-820d-43f6-93a7-7cf1863a8565
- date added to LUP
- 2022-08-19 17:08:20
- date last changed
- 2024-04-18 05:19:41
@article{9985a8fe-820d-43f6-93a7-7cf1863a8565,
abstract = {{<p>Objective:To assess cardiovascular effects of in-utero HIV and antiretroviral treatment (ART) exposure on offspring of HIV-positive mothers in Ethiopia.Design:HIV-positive and HIV-negative pregnancies were identified from a prospective cohort of women recruited at their first antenatal care visit in Ethiopia, using a nested case-control design.Methods:Fetal standard ultrasound and echocardiography were performed at 2237 weeks of pregnancy to assess fetal biometry and cardiac structure. Postnatal cardiovascular evaluation, including echocardiography and vascular assessment, was performed at 6 months of age. Cardiovascular data were correlated to HIV serostatus, antiretroviral drug exposure and HIV-unrelated maternal characteristics.Results:Fetuses from 29 HIV-positive and 67 HIV-negative women paired by gestational age at scan were included. Among HIV-positive women, 25 were on ART before conception, and 4 initiated ART during pregnancy. Estimated fetal weight was similar in both groups [mean 1873 g (standard deviation; SD 569) vs. 1839 g (SD 579) P = 0.79, respectively]. Fetal cardiac morphometry was similar with regard to maternal HIV serostatus: cardiothoracic ratio mean 0.26 (SD 0.05) vs. 0.25 (SD 0.06), P = 0.48; and septal wall thickness mean 4.03 mm (SD 0.58) vs. 3.98 mm (SD 0.70), P = 0.94. No significant cardiovascular differences were detected postnatally according to maternal HIV serostatus: septal wall thickness mean 5.46 mm (SD 0.65) vs. 5.49 (SD 0.89); P = 0.896; isovolumic relaxation time 55.08 ms (SD 6.57) vs. 56.56 (SD 6.74); P = 0.359.Conclusion:In offspring of Ethiopian women, intrauterine exposure to HIV and ART were not associated with cardiovascular changes from fetal life up to infanthood.</p>}},
author = {{García-Otero, Laura and Walles, John and Balcha, Taye Tolera and Merga, Gadissa and López, Marta and Crispi, Fatima and Björkman, Per}},
issn = {{0269-9370}},
keywords = {{Antiretroviral therapy; cardiac; echocardiography; fetal heart; HIV; sub-Saharan Africa}},
language = {{eng}},
month = {{06}},
number = {{7}},
pages = {{941--951}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{AIDS}},
title = {{Cardiovascular effects of intrauterine exposure to maternal HIV and antiretroviral therapy in Ethiopian infants followed from fetal life}},
url = {{http://dx.doi.org/10.1097/QAD.0000000000003188}},
doi = {{10.1097/QAD.0000000000003188}},
volume = {{36}},
year = {{2022}},
}