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Stimulation within the cuneate nucleus suppresses synaptic activation of climbing fibers.

Geborek, Pontus LU ; Jörntell, Henrik LU and Bengtsson, Fredrik LU (2013) In Frontiers in Neural Circuits 6(120). p.1-9
Abstract
Several lines of research have shown that the excitability of the inferior olive is suppressed during different phases of movement. A number of different structures like the cerebral cortex, the red nucleus, and the cerebellum have been suggested as candidate structures for mediating this gating. The inhibition of the responses of the inferior olivary neurons from the red nucleus has been studied extensively and anatomical studies have found specific areas within the cuneate nucleus to be target areas for projections from the magnocellular red nucleus. In addition, GABA-ergic cells projecting from the cuneate nucleus to the inferior olive have been found. We therefore tested if direct stimulation of the cuneate nucleus had inhibitory... (More)
Several lines of research have shown that the excitability of the inferior olive is suppressed during different phases of movement. A number of different structures like the cerebral cortex, the red nucleus, and the cerebellum have been suggested as candidate structures for mediating this gating. The inhibition of the responses of the inferior olivary neurons from the red nucleus has been studied extensively and anatomical studies have found specific areas within the cuneate nucleus to be target areas for projections from the magnocellular red nucleus. In addition, GABA-ergic cells projecting from the cuneate nucleus to the inferior olive have been found. We therefore tested if direct stimulation of the cuneate nucleus had inhibitory effects on a climbing fiber field response, evoked by electrical stimulation of the pyramidal tract, recorded on the surface of the cerebellum. When the pyramidal tract stimulation was preceded by weak electrical stimulation (5-20 μA) within the cuneate nucleus, the amplitude of the climbing fiber field potential was strongly suppressed (approx. 90% reduction). The time course of this suppression was similar to that found after red nucleus stimulation, with a peak suppression occurring at 70 ms after the cuneate stimulation. Application of CNQX (6-cyano-7-nitroquinoxaline-2,3-dione, disodium salt) on the cuneate nucleus blocked the suppression almost completely. We conclude that a relay through the cuneate nucleus is a possible pathway for movement-related suppression of climbing fiber excitability. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Frontiers in Neural Circuits
volume
6
issue
120
pages
1 - 9
publisher
Frontiers Media S. A.
external identifiers
  • wos:000313615300001
  • pmid:23335886
  • scopus:84872082314
  • pmid:23335886
ISSN
1662-5110
DOI
10.3389/fncir.2012.00120
language
English
LU publication?
yes
id
99966cfa-d8ac-4023-8973-4993b9c1f3e6 (old id 3438532)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23335886?dopt=Abstract
date added to LUP
2016-04-01 14:34:25
date last changed
2022-01-28 01:19:27
@article{99966cfa-d8ac-4023-8973-4993b9c1f3e6,
  abstract     = {{Several lines of research have shown that the excitability of the inferior olive is suppressed during different phases of movement. A number of different structures like the cerebral cortex, the red nucleus, and the cerebellum have been suggested as candidate structures for mediating this gating. The inhibition of the responses of the inferior olivary neurons from the red nucleus has been studied extensively and anatomical studies have found specific areas within the cuneate nucleus to be target areas for projections from the magnocellular red nucleus. In addition, GABA-ergic cells projecting from the cuneate nucleus to the inferior olive have been found. We therefore tested if direct stimulation of the cuneate nucleus had inhibitory effects on a climbing fiber field response, evoked by electrical stimulation of the pyramidal tract, recorded on the surface of the cerebellum. When the pyramidal tract stimulation was preceded by weak electrical stimulation (5-20 μA) within the cuneate nucleus, the amplitude of the climbing fiber field potential was strongly suppressed (approx. 90% reduction). The time course of this suppression was similar to that found after red nucleus stimulation, with a peak suppression occurring at 70 ms after the cuneate stimulation. Application of CNQX (6-cyano-7-nitroquinoxaline-2,3-dione, disodium salt) on the cuneate nucleus blocked the suppression almost completely. We conclude that a relay through the cuneate nucleus is a possible pathway for movement-related suppression of climbing fiber excitability.}},
  author       = {{Geborek, Pontus and Jörntell, Henrik and Bengtsson, Fredrik}},
  issn         = {{1662-5110}},
  language     = {{eng}},
  number       = {{120}},
  pages        = {{1--9}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Neural Circuits}},
  title        = {{Stimulation within the cuneate nucleus suppresses synaptic activation of climbing fibers.}},
  url          = {{https://lup.lub.lu.se/search/files/4043015/3900963.pdf}},
  doi          = {{10.3389/fncir.2012.00120}},
  volume       = {{6}},
  year         = {{2013}},
}