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Photoluminescent and tough hydrogels from silk fibroin and polyacrylic acid complexed with europium

Zhao, Yu ; Puthia, Manoj LU ; Jo, Seong Min ; Guan, Juan ; Liu, Mingjie and Wu, Sujun (2024) In Journal of Applied Polymer Science
Abstract

Biocompatible, tough, and photoluminescent hydrogels are highly desirable for biomedical applications in vivo. Herein, hybrid hydrogels prepared from silk fibroin (SF) and polyacrylic acid (PAA) and complexed with europium, named as SF-PAA-Eu3+ hydrogels, exhibit good comprehensive properties. Owing to the intensive molecular interactions among SF, PAA, and Eu3+, SF-PAA-Eu3+ hydrogels show a greatest tensile strength of 0.58 MPa, elongation of 443%, and work of fracture of 1.65 MJ/m. In vivo imaging experiment in a mouse subcutaneous implantation model revealed excellent and sustained photoluminescence of the SF-PAA-Eu3+ hydrogels for 24 h. The work provides a strategy for designing functional... (More)

Biocompatible, tough, and photoluminescent hydrogels are highly desirable for biomedical applications in vivo. Herein, hybrid hydrogels prepared from silk fibroin (SF) and polyacrylic acid (PAA) and complexed with europium, named as SF-PAA-Eu3+ hydrogels, exhibit good comprehensive properties. Owing to the intensive molecular interactions among SF, PAA, and Eu3+, SF-PAA-Eu3+ hydrogels show a greatest tensile strength of 0.58 MPa, elongation of 443%, and work of fracture of 1.65 MJ/m. In vivo imaging experiment in a mouse subcutaneous implantation model revealed excellent and sustained photoluminescence of the SF-PAA-Eu3+ hydrogels for 24 h. The work provides a strategy for designing functional SF-based hydrogels for imaging applications in vivo.

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author
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organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
double network, europium, hydrogel, photoluminescence, silk fibroin
in
Journal of Applied Polymer Science
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85182426027
ISSN
0021-8995
DOI
10.1002/app.55213
language
English
LU publication?
yes
id
99ac25dc-ec40-495a-9b87-2fc62936fe7c
date added to LUP
2024-02-16 13:22:04
date last changed
2024-02-16 13:24:23
@article{99ac25dc-ec40-495a-9b87-2fc62936fe7c,
  abstract     = {{<p>Biocompatible, tough, and photoluminescent hydrogels are highly desirable for biomedical applications in vivo. Herein, hybrid hydrogels prepared from silk fibroin (SF) and polyacrylic acid (PAA) and complexed with europium, named as SF-PAA-Eu<sup>3+</sup> hydrogels, exhibit good comprehensive properties. Owing to the intensive molecular interactions among SF, PAA, and Eu<sup>3+</sup>, SF-PAA-Eu<sup>3+</sup> hydrogels show a greatest tensile strength of 0.58 MPa, elongation of 443%, and work of fracture of 1.65 MJ/m. In vivo imaging experiment in a mouse subcutaneous implantation model revealed excellent and sustained photoluminescence of the SF-PAA-Eu<sup>3+</sup> hydrogels for 24 h. The work provides a strategy for designing functional SF-based hydrogels for imaging applications in vivo.</p>}},
  author       = {{Zhao, Yu and Puthia, Manoj and Jo, Seong Min and Guan, Juan and Liu, Mingjie and Wu, Sujun}},
  issn         = {{0021-8995}},
  keywords     = {{double network; europium; hydrogel; photoluminescence; silk fibroin}},
  language     = {{eng}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Journal of Applied Polymer Science}},
  title        = {{Photoluminescent and tough hydrogels from silk fibroin and polyacrylic acid complexed with europium}},
  url          = {{http://dx.doi.org/10.1002/app.55213}},
  doi          = {{10.1002/app.55213}},
  year         = {{2024}},
}