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Quantification of [18F]florbetaben amyloid-PET imaging in a mixed memory clinic population : The ABIDE project

Collij, Lyduine E. LU ; Salvadó, Gemma LU ; de Wilde, Arno ; Altomare, Daniele ; Shekari, Mahnaz ; Gispert, Juan Domingo ; Bullich, Santiago ; Stephens, Andrew ; Barkhof, Frederik and Scheltens, Philip , et al. (2023) In Alzheimer's and Dementia 19(6). p.2397-2407
Abstract

Introduction: We investigated amyloid-burden quantification in a mixed memory clinic population. Methods: [18F]Florbetaben amyloid-PET (positron emission tomography) scans of 348 patients were visually read and quantified using the Centiloid (CL) method. General linear models were used to assess CL differences across syndromic and etiological diagnosis. Linear mixed models were fitted to assess the predictive value of visual read (VR) and CL on longitudinal Mini-Mental Status Examination (MMSE). Results: CL was associated with syndromic (F = 4.42, p = 0.014) and etiological diagnosis (F = -12.66, p < 0.001), with Alzheimer's disease (AD) patients showing the highest amyloid burden (62.9 ± 27.5), followed by dementia with... (More)

Introduction: We investigated amyloid-burden quantification in a mixed memory clinic population. Methods: [18F]Florbetaben amyloid-PET (positron emission tomography) scans of 348 patients were visually read and quantified using the Centiloid (CL) method. General linear models were used to assess CL differences across syndromic and etiological diagnosis. Linear mixed models were fitted to assess the predictive value of visual read (VR) and CL on longitudinal Mini-Mental Status Examination (MMSE). Results: CL was associated with syndromic (F = 4.42, p = 0.014) and etiological diagnosis (F = -12.66, p < 0.001), with Alzheimer's disease (AD) patients showing the highest amyloid burden (62.9 ± 27.5), followed by dementia with Lewy bodies (DLB) (25.3 ± 35.5) and cardiovascular disease (CVD) (16.7 ± 24.5), and finally frontotemporal lobe degeneration (FTLD) (5.0 ± 17.22, t = –12.66, p < 0.001). CL remained predictive of etiological diagnosis (t = –2.41, p = 0.017) within the VR+ population (N = 157). VR was not a significant predictor of MMSE (t = –1.53, p = 0.13) for the SCD population (N = 90), whereas CL was (t = -3.30, p = 0.001). Discussion: The extent of amyloid pathology through quantification holds clinical value, potentially in the context of differential diagnosis as well as prognosis.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Amyloid-PET, Centiloid quantification, Dementia, Diagnosis, Prognosis
in
Alzheimer's and Dementia
volume
19
issue
6
pages
2397 - 2407
publisher
Wiley
external identifiers
  • scopus:85144070304
  • pmid:36478646
ISSN
1552-5260
DOI
10.1002/alz.12886
language
English
LU publication?
yes
id
99ad149f-46b8-410e-9047-1b7aad86c450
date added to LUP
2023-01-25 13:10:48
date last changed
2024-06-27 15:13:30
@article{99ad149f-46b8-410e-9047-1b7aad86c450,
  abstract     = {{<p>Introduction: We investigated amyloid-burden quantification in a mixed memory clinic population. Methods: [<sup>18</sup>F]Florbetaben amyloid-PET (positron emission tomography) scans of 348 patients were visually read and quantified using the Centiloid (CL) method. General linear models were used to assess CL differences across syndromic and etiological diagnosis. Linear mixed models were fitted to assess the predictive value of visual read (VR) and CL on longitudinal Mini-Mental Status Examination (MMSE). Results: CL was associated with syndromic (F = 4.42, p = 0.014) and etiological diagnosis (F = -12.66, p &lt; 0.001), with Alzheimer's disease (AD) patients showing the highest amyloid burden (62.9 ± 27.5), followed by dementia with Lewy bodies (DLB) (25.3 ± 35.5) and cardiovascular disease (CVD) (16.7 ± 24.5), and finally frontotemporal lobe degeneration (FTLD) (5.0 ± 17.22, t = –12.66, p &lt; 0.001). CL remained predictive of etiological diagnosis (t = –2.41, p = 0.017) within the VR+ population (N = 157). VR was not a significant predictor of MMSE (t = –1.53, p = 0.13) for the SCD population (N = 90), whereas CL was (t = -3.30, p = 0.001). Discussion: The extent of amyloid pathology through quantification holds clinical value, potentially in the context of differential diagnosis as well as prognosis.</p>}},
  author       = {{Collij, Lyduine E. and Salvadó, Gemma and de Wilde, Arno and Altomare, Daniele and Shekari, Mahnaz and Gispert, Juan Domingo and Bullich, Santiago and Stephens, Andrew and Barkhof, Frederik and Scheltens, Philip and Bouwman, Femke and van der Flier, Wiesje M.}},
  issn         = {{1552-5260}},
  keywords     = {{Amyloid-PET; Centiloid quantification; Dementia; Diagnosis; Prognosis}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{2397--2407}},
  publisher    = {{Wiley}},
  series       = {{Alzheimer's and Dementia}},
  title        = {{Quantification of [<sup>18</sup>F]florbetaben amyloid-PET imaging in a mixed memory clinic population : The ABIDE project}},
  url          = {{http://dx.doi.org/10.1002/alz.12886}},
  doi          = {{10.1002/alz.12886}},
  volume       = {{19}},
  year         = {{2023}},
}