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Allergic Contact Dermatitis from Methylisothiazolinone in Residential Wall Paint

Goodier, Molly C.; Ljungberg, Linda LU ; Persson, Christina LU ; Engfeldt, Malin LU ; Bruze, Magnus LU and Warshaw, Erin M (2017) In Dermatitis 28(4). p.284-287
Abstract

A 33-year-old woman presented to our clinic for suspected photoallergic contact dermatitis with a recent episode of severe, vesicular dermatitis involving exposed skin and correlating with relocation to a new home. Biopsy results showed spongiotic and lichenoid dermatitis with eosinophils. Patch test results showed a very strong (+++) reaction to methylisothiazolinone (MI), mild (+) reaction to MI/methylchloroisothiazolinone, and no reaction to benzisothiazolinone. These allergens were found in several personal products. However, the patient was suspicious of 4 wall paints recently used in her home. Semiopen patch tests to 3 Behr interior paints showed positive results. Nine controls showed negative results. High-performance liquid... (More)

A 33-year-old woman presented to our clinic for suspected photoallergic contact dermatitis with a recent episode of severe, vesicular dermatitis involving exposed skin and correlating with relocation to a new home. Biopsy results showed spongiotic and lichenoid dermatitis with eosinophils. Patch test results showed a very strong (+++) reaction to methylisothiazolinone (MI), mild (+) reaction to MI/methylchloroisothiazolinone, and no reaction to benzisothiazolinone. These allergens were found in several personal products. However, the patient was suspicious of 4 wall paints recently used in her home. Semiopen patch tests to 3 Behr interior paints showed positive results. Nine controls showed negative results. High-performance liquid chromatography demonstrated MI and benzisothiazolinone in all 4 paints at concentrations ranging from 50 to 100 ppm and 290 to 340 ppm, respectively. Although MI has been reported to cause occupational airborne contact dermatitis in European household painters, to our knowledge, this is the first documented case of paint-related MI allergy in the United States.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dermatitis
volume
28
issue
4
pages
4 pages
publisher
BC Decker
external identifiers
  • scopus:85025135407
  • wos:000405707400010
ISSN
1710-3568
DOI
10.1097/DER.0000000000000294
language
English
LU publication?
yes
id
99b0b0ec-0336-4bea-9860-a3bbbcf71674
date added to LUP
2017-08-25 14:26:41
date last changed
2017-09-18 11:43:15
@article{99b0b0ec-0336-4bea-9860-a3bbbcf71674,
  abstract     = {<p>A 33-year-old woman presented to our clinic for suspected photoallergic contact dermatitis with a recent episode of severe, vesicular dermatitis involving exposed skin and correlating with relocation to a new home. Biopsy results showed spongiotic and lichenoid dermatitis with eosinophils. Patch test results showed a very strong (+++) reaction to methylisothiazolinone (MI), mild (+) reaction to MI/methylchloroisothiazolinone, and no reaction to benzisothiazolinone. These allergens were found in several personal products. However, the patient was suspicious of 4 wall paints recently used in her home. Semiopen patch tests to 3 Behr interior paints showed positive results. Nine controls showed negative results. High-performance liquid chromatography demonstrated MI and benzisothiazolinone in all 4 paints at concentrations ranging from 50 to 100 ppm and 290 to 340 ppm, respectively. Although MI has been reported to cause occupational airborne contact dermatitis in European household painters, to our knowledge, this is the first documented case of paint-related MI allergy in the United States.</p>},
  author       = {Goodier, Molly C. and Ljungberg, Linda and Persson, Christina and Engfeldt, Malin and Bruze, Magnus and Warshaw, Erin M},
  issn         = {1710-3568},
  language     = {eng},
  month        = {07},
  number       = {4},
  pages        = {284--287},
  publisher    = {BC Decker},
  series       = {Dermatitis},
  title        = {Allergic Contact Dermatitis from Methylisothiazolinone in Residential Wall Paint},
  url          = {http://dx.doi.org/10.1097/DER.0000000000000294},
  volume       = {28},
  year         = {2017},
}