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Comparison of Ultrafast Dynamic Contrast-Enhanced (DCE) MRI with Conventional DCE MRI in the Morphological Assessment of Malignant Breast Lesions

Ohashi, Akane LU ; Kataoka, Masako ; Iima, Mami ; Honda, Maya ; Ota, Rie ; Urushibata, Yuta ; Nickel, Marcel Dominik ; Toi, Masakazu ; Zackrisson, Sophia LU and Nakamoto, Yuji (2023) In Diagnostics 13(6).
Abstract

Ultrafast (UF) dynamic contrast-enhanced (DCE)-MRI offers the potential for a faster and, therefore, less expensive examination of breast lesions; however, there are no reports that have evaluated whether UF DCE-MRI can be used the same as conventional DCE-MRI in the reading of morphological information. This study evaluated the agreement in morphological information obtained from malignant breast mass lesions between UF DCE-MRI and conventional DCE-MRI. UF DCE-MRI data were obtained over the first 60 s post-contrast injection, followed by the conventional DCE images. Two readers evaluated the size and morphology of the lesions in the final phase of the UF DCE-MRI and the early phase of the conventional DCE-MRI. Inter-method agreement... (More)

Ultrafast (UF) dynamic contrast-enhanced (DCE)-MRI offers the potential for a faster and, therefore, less expensive examination of breast lesions; however, there are no reports that have evaluated whether UF DCE-MRI can be used the same as conventional DCE-MRI in the reading of morphological information. This study evaluated the agreement in morphological information obtained from malignant breast mass lesions between UF DCE-MRI and conventional DCE-MRI. UF DCE-MRI data were obtained over the first 60 s post-contrast injection, followed by the conventional DCE images. Two readers evaluated the size and morphology of the lesions in the final phase of the UF DCE-MRI and the early phase of the conventional DCE-MRI. Inter-method agreement in morphological information was evaluated for the two readers using the intraclass correlation coefficient for size, and the kappa statistics for the morphological descriptors. Differences in the proportion of each descriptor were examined using Fisher’s test of independence. Most inter-method agreements were higher than substantial. UF DCE-MRI showed a circumscribed margin and homogeneous enhancement more often than conventional imaging. However, the percentages of readings showing the same morphology assessment between the UF DCE-MRI and conventional DCE-MRI were 71.2% (136/191) for Reader 1 and 69.1% (132/191) for Reader 2. We conclude that UF DCE-MRI may replace conventional DCE-MRI to evaluate the morphological information of malignant breast mass lesions.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
breast MRI, morphology, ultrafast DCE-MRI
in
Diagnostics
volume
13
issue
6
article number
1105
publisher
MDPI AG
external identifiers
  • pmid:36980417
  • scopus:85151352001
ISSN
2075-4418
DOI
10.3390/diagnostics13061105
language
English
LU publication?
yes
id
99d9ebcb-3ebc-4634-aa05-e70366fb0b39
date added to LUP
2023-05-23 12:12:51
date last changed
2024-04-19 22:06:46
@article{99d9ebcb-3ebc-4634-aa05-e70366fb0b39,
  abstract     = {{<p>Ultrafast (UF) dynamic contrast-enhanced (DCE)-MRI offers the potential for a faster and, therefore, less expensive examination of breast lesions; however, there are no reports that have evaluated whether UF DCE-MRI can be used the same as conventional DCE-MRI in the reading of morphological information. This study evaluated the agreement in morphological information obtained from malignant breast mass lesions between UF DCE-MRI and conventional DCE-MRI. UF DCE-MRI data were obtained over the first 60 s post-contrast injection, followed by the conventional DCE images. Two readers evaluated the size and morphology of the lesions in the final phase of the UF DCE-MRI and the early phase of the conventional DCE-MRI. Inter-method agreement in morphological information was evaluated for the two readers using the intraclass correlation coefficient for size, and the kappa statistics for the morphological descriptors. Differences in the proportion of each descriptor were examined using Fisher’s test of independence. Most inter-method agreements were higher than substantial. UF DCE-MRI showed a circumscribed margin and homogeneous enhancement more often than conventional imaging. However, the percentages of readings showing the same morphology assessment between the UF DCE-MRI and conventional DCE-MRI were 71.2% (136/191) for Reader 1 and 69.1% (132/191) for Reader 2. We conclude that UF DCE-MRI may replace conventional DCE-MRI to evaluate the morphological information of malignant breast mass lesions.</p>}},
  author       = {{Ohashi, Akane and Kataoka, Masako and Iima, Mami and Honda, Maya and Ota, Rie and Urushibata, Yuta and Nickel, Marcel Dominik and Toi, Masakazu and Zackrisson, Sophia and Nakamoto, Yuji}},
  issn         = {{2075-4418}},
  keywords     = {{breast MRI; morphology; ultrafast DCE-MRI}},
  language     = {{eng}},
  number       = {{6}},
  publisher    = {{MDPI AG}},
  series       = {{Diagnostics}},
  title        = {{Comparison of Ultrafast Dynamic Contrast-Enhanced (DCE) MRI with Conventional DCE MRI in the Morphological Assessment of Malignant Breast Lesions}},
  url          = {{http://dx.doi.org/10.3390/diagnostics13061105}},
  doi          = {{10.3390/diagnostics13061105}},
  volume       = {{13}},
  year         = {{2023}},
}