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Detection of HPV mRNA in Self-collected Vaginal Samples Among Urban Ethiopian Women

Mekuria, Selamawit LU ; Jerkeman, Mats LU ; Forslund, Ola LU ; Fikru, Saba and Borgfeldt, Christer LU (2020) In Anticancer research 40(3). p.1513-1517
Abstract

BACKGROUND/AIM: Cervical cancer is the most common cancer among women in Ethiopia. The objective was to evaluate the participation rate of a free of charge vaginal self-sample (Aptima multitest swab, Hologic) for the detection of human papillomavirus (HPV) in an Ethiopian cohort. PATIENTS AND METHODS: Specimens were collected from women employed by Ethiopian Airlines in Addis Abeba (N=5950). Samples were analysed for the presence of high-risk (HR) HPV mRNA by the Aptima HPV assay (Hologic) and HPV positive women were referred for cytology. Identification of HPV types among HPV positive samples was performed by Modified general primer-PCR and Luminex assay. RESULTS: Participation rate was 3.1% and the prevalence of HPV mRNA was 20.6%... (More)

BACKGROUND/AIM: Cervical cancer is the most common cancer among women in Ethiopia. The objective was to evaluate the participation rate of a free of charge vaginal self-sample (Aptima multitest swab, Hologic) for the detection of human papillomavirus (HPV) in an Ethiopian cohort. PATIENTS AND METHODS: Specimens were collected from women employed by Ethiopian Airlines in Addis Abeba (N=5950). Samples were analysed for the presence of high-risk (HR) HPV mRNA by the Aptima HPV assay (Hologic) and HPV positive women were referred for cytology. Identification of HPV types among HPV positive samples was performed by Modified general primer-PCR and Luminex assay. RESULTS: Participation rate was 3.1% and the prevalence of HPV mRNA was 20.6% (37/180). CONCLUSION: Primary HPV mRNA screening with vaginal self-sampling may be an acceptable approach in Ethiopia. One out of five women harbor HPV in their vaginal self-sample in agreement with other similar studies from the region.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cervical cancer, Ethiopia, HPV, screening, self-sampling
in
Anticancer research
volume
40
issue
3
pages
1513 - 1517
publisher
International Institute of Cancer Research
external identifiers
  • scopus:85081311006
  • pmid:32132051
ISSN
1791-7530
DOI
10.21873/anticanres.14096
language
English
LU publication?
yes
id
9a45f00b-3774-46ff-9b77-a6267bf60f94
date added to LUP
2020-03-27 10:24:29
date last changed
2025-04-04 15:03:59
@article{9a45f00b-3774-46ff-9b77-a6267bf60f94,
  abstract     = {{<p>BACKGROUND/AIM: Cervical cancer is the most common cancer among women in Ethiopia. The objective was to evaluate the participation rate of a free of charge vaginal self-sample (Aptima multitest swab, Hologic) for the detection of human papillomavirus (HPV) in an Ethiopian cohort. PATIENTS AND METHODS: Specimens were collected from women employed by Ethiopian Airlines in Addis Abeba (N=5950). Samples were analysed for the presence of high-risk (HR) HPV mRNA by the Aptima HPV assay (Hologic) and HPV positive women were referred for cytology. Identification of HPV types among HPV positive samples was performed by Modified general primer-PCR and Luminex assay. RESULTS: Participation rate was 3.1% and the prevalence of HPV mRNA was 20.6% (37/180). CONCLUSION: Primary HPV mRNA screening with vaginal self-sampling may be an acceptable approach in Ethiopia. One out of five women harbor HPV in their vaginal self-sample in agreement with other similar studies from the region.</p>}},
  author       = {{Mekuria, Selamawit and Jerkeman, Mats and Forslund, Ola and Fikru, Saba and Borgfeldt, Christer}},
  issn         = {{1791-7530}},
  keywords     = {{cervical cancer; Ethiopia; HPV; screening; self-sampling}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{1513--1517}},
  publisher    = {{International Institute of Cancer Research}},
  series       = {{Anticancer research}},
  title        = {{Detection of HPV mRNA in Self-collected Vaginal Samples Among Urban Ethiopian Women}},
  url          = {{http://dx.doi.org/10.21873/anticanres.14096}},
  doi          = {{10.21873/anticanres.14096}},
  volume       = {{40}},
  year         = {{2020}},
}