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Association between serum urate and CSF markers of Alzheimer's disease pathology in a population-based sample of 70-year-olds

Fatima, Tahzeeb LU ; Jacobsson, Lennart T.H. LU ; Kern, Silke ; Zettergren, Anna ; Blennow, Kaj LU ; Zetterberg, Henrik LU ; Johansson, Lena LU ; Dehlin, Mats and Skoog, Ingmar (2021) In Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 13(1).
Abstract

Introduction: The relationship between urate and biomarkers for Alzheimer's disease (AD) pathophysiology has not been investigated. Methods: We examined whether serum concentration of urate was associated with cerebrospinal fluid biomarkers, amyloid beta (Aβ)42, Aβ40, phosphorylated tau (p-tau), total tau (t-tau), neurofilament light (NfL), and Aβ42/Aβ40 ratio, in cognitively unimpaired 70-year-old individuals from Gothenburg, Sweden. We also evaluated whether possible associations were modulated by the apolipoprotein E (APOE) ε4 allele. Results: Serum urate was positively associated with Aβ42 in males (β = 0.55 pg/mL, P =.04). There was a positive urate–APOE ε4 interaction (1.24... (More)

Introduction: The relationship between urate and biomarkers for Alzheimer's disease (AD) pathophysiology has not been investigated. Methods: We examined whether serum concentration of urate was associated with cerebrospinal fluid biomarkers, amyloid beta (Aβ)42, Aβ40, phosphorylated tau (p-tau), total tau (t-tau), neurofilament light (NfL), and Aβ42/Aβ40 ratio, in cognitively unimpaired 70-year-old individuals from Gothenburg, Sweden. We also evaluated whether possible associations were modulated by the apolipoprotein E (APOE) ε4 allele. Results: Serum urate was positively associated with Aβ42 in males (β = 0.55 pg/mL, P =.04). There was a positive urate–APOE ε4 interaction (1.24 pg/mL, Pinteraction =.02) in relation to Aβ42 association. The positive urate and Aβ42 association strengthened in male APOE ε4 carriers (β = 1.28 pg/mL, P =.01). Discussion: The positive association between urate and Aβ42 in cognitively healthy men may suggest a protective effect of urate against deposition of amyloid protein in the brain parenchyma, and in the longer term, maybe against AD dementia.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, apolipoprotein E ε4, cerebrospinal fluid biomarkers, dementia, urate
in
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
volume
13
issue
1
article number
e12241
publisher
Elsevier
external identifiers
  • pmid:34934798
  • scopus:85125100757
ISSN
2352-8729
DOI
10.1002/dad2.12241
language
English
LU publication?
yes
id
9a4c5b3f-2b9a-4ed1-974a-e96007dc04a4
date added to LUP
2022-04-13 17:14:50
date last changed
2024-02-24 01:29:38
@article{9a4c5b3f-2b9a-4ed1-974a-e96007dc04a4,
  abstract     = {{<p>Introduction: The relationship between urate and biomarkers for Alzheimer's disease (AD) pathophysiology has not been investigated. Methods: We examined whether serum concentration of urate was associated with cerebrospinal fluid biomarkers, amyloid beta (Aβ)<sub>42</sub>, Aβ<sub>40</sub>, phosphorylated tau (p-tau), total tau (t-tau), neurofilament light (NfL), and Aβ<sub>42</sub>/Aβ<sub>40</sub> ratio, in cognitively unimpaired 70-year-old individuals from Gothenburg, Sweden. We also evaluated whether possible associations were modulated by the apolipoprotein E (APOE) ε4 allele. Results: Serum urate was positively associated with Aβ<sub>42</sub> in males (β = 0.55 pg/mL, P =.04). There was a positive urate–APOE ε4 interaction (1.24 pg/mL, P<sub>interaction</sub> =.02) in relation to Aβ<sub>42</sub> association. The positive urate and Aβ<sub>42</sub> association strengthened in male APOE ε4 carriers (β = 1.28 pg/mL, P =.01). Discussion: The positive association between urate and Aβ<sub>42</sub> in cognitively healthy men may suggest a protective effect of urate against deposition of amyloid protein in the brain parenchyma, and in the longer term, maybe against AD dementia.</p>}},
  author       = {{Fatima, Tahzeeb and Jacobsson, Lennart T.H. and Kern, Silke and Zettergren, Anna and Blennow, Kaj and Zetterberg, Henrik and Johansson, Lena and Dehlin, Mats and Skoog, Ingmar}},
  issn         = {{2352-8729}},
  keywords     = {{Alzheimer's disease; apolipoprotein E ε4; cerebrospinal fluid biomarkers; dementia; urate}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Elsevier}},
  series       = {{Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring}},
  title        = {{Association between serum urate and CSF markers of Alzheimer's disease pathology in a population-based sample of 70-year-olds}},
  url          = {{http://dx.doi.org/10.1002/dad2.12241}},
  doi          = {{10.1002/dad2.12241}},
  volume       = {{13}},
  year         = {{2021}},
}