Association between serum urate and CSF markers of Alzheimer's disease pathology in a population-based sample of 70-year-olds
(2021) In Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 13(1).- Abstract
Introduction: The relationship between urate and biomarkers for Alzheimer's disease (AD) pathophysiology has not been investigated. Methods: We examined whether serum concentration of urate was associated with cerebrospinal fluid biomarkers, amyloid beta (Aβ)42, Aβ40, phosphorylated tau (p-tau), total tau (t-tau), neurofilament light (NfL), and Aβ42/Aβ40 ratio, in cognitively unimpaired 70-year-old individuals from Gothenburg, Sweden. We also evaluated whether possible associations were modulated by the apolipoprotein E (APOE) ε4 allele. Results: Serum urate was positively associated with Aβ42 in males (β = 0.55 pg/mL, P =.04). There was a positive urate–APOE ε4 interaction (1.24... (More)
Introduction: The relationship between urate and biomarkers for Alzheimer's disease (AD) pathophysiology has not been investigated. Methods: We examined whether serum concentration of urate was associated with cerebrospinal fluid biomarkers, amyloid beta (Aβ)42, Aβ40, phosphorylated tau (p-tau), total tau (t-tau), neurofilament light (NfL), and Aβ42/Aβ40 ratio, in cognitively unimpaired 70-year-old individuals from Gothenburg, Sweden. We also evaluated whether possible associations were modulated by the apolipoprotein E (APOE) ε4 allele. Results: Serum urate was positively associated with Aβ42 in males (β = 0.55 pg/mL, P =.04). There was a positive urate–APOE ε4 interaction (1.24 pg/mL, Pinteraction =.02) in relation to Aβ42 association. The positive urate and Aβ42 association strengthened in male APOE ε4 carriers (β = 1.28 pg/mL, P =.01). Discussion: The positive association between urate and Aβ42 in cognitively healthy men may suggest a protective effect of urate against deposition of amyloid protein in the brain parenchyma, and in the longer term, maybe against AD dementia.
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- author
- Fatima, Tahzeeb LU ; Jacobsson, Lennart T.H. LU ; Kern, Silke ; Zettergren, Anna ; Blennow, Kaj LU ; Zetterberg, Henrik LU ; Johansson, Lena LU ; Dehlin, Mats and Skoog, Ingmar
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alzheimer's disease, apolipoprotein E ε4, cerebrospinal fluid biomarkers, dementia, urate
- in
- Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
- volume
- 13
- issue
- 1
- article number
- e12241
- publisher
- Elsevier
- external identifiers
-
- scopus:85125100757
- pmid:34934798
- ISSN
- 2352-8729
- DOI
- 10.1002/dad2.12241
- language
- English
- LU publication?
- yes
- id
- 9a4c5b3f-2b9a-4ed1-974a-e96007dc04a4
- date added to LUP
- 2022-04-13 17:14:50
- date last changed
- 2025-01-29 15:40:54
@article{9a4c5b3f-2b9a-4ed1-974a-e96007dc04a4, abstract = {{<p>Introduction: The relationship between urate and biomarkers for Alzheimer's disease (AD) pathophysiology has not been investigated. Methods: We examined whether serum concentration of urate was associated with cerebrospinal fluid biomarkers, amyloid beta (Aβ)<sub>42</sub>, Aβ<sub>40</sub>, phosphorylated tau (p-tau), total tau (t-tau), neurofilament light (NfL), and Aβ<sub>42</sub>/Aβ<sub>40</sub> ratio, in cognitively unimpaired 70-year-old individuals from Gothenburg, Sweden. We also evaluated whether possible associations were modulated by the apolipoprotein E (APOE) ε4 allele. Results: Serum urate was positively associated with Aβ<sub>42</sub> in males (β = 0.55 pg/mL, P =.04). There was a positive urate–APOE ε4 interaction (1.24 pg/mL, P<sub>interaction</sub> =.02) in relation to Aβ<sub>42</sub> association. The positive urate and Aβ<sub>42</sub> association strengthened in male APOE ε4 carriers (β = 1.28 pg/mL, P =.01). Discussion: The positive association between urate and Aβ<sub>42</sub> in cognitively healthy men may suggest a protective effect of urate against deposition of amyloid protein in the brain parenchyma, and in the longer term, maybe against AD dementia.</p>}}, author = {{Fatima, Tahzeeb and Jacobsson, Lennart T.H. and Kern, Silke and Zettergren, Anna and Blennow, Kaj and Zetterberg, Henrik and Johansson, Lena and Dehlin, Mats and Skoog, Ingmar}}, issn = {{2352-8729}}, keywords = {{Alzheimer's disease; apolipoprotein E ε4; cerebrospinal fluid biomarkers; dementia; urate}}, language = {{eng}}, number = {{1}}, publisher = {{Elsevier}}, series = {{Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring}}, title = {{Association between serum urate and CSF markers of Alzheimer's disease pathology in a population-based sample of 70-year-olds}}, url = {{http://dx.doi.org/10.1002/dad2.12241}}, doi = {{10.1002/dad2.12241}}, volume = {{13}}, year = {{2021}}, }