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Mass spectrometry of peptides in neuroscience

Nilsson, Carol LU ; Karlsson, G; Bergquist, J; Westman, A. and Ekman, R (1998) In Peptides 19(4). p.9-781
Abstract

This review focuses on the contributions of modern mass spectrometry to neuropeptide research. An introduction to newer mass spectrometric techniques is provided. Also, the use of mass spectrometry in combination with high-resolution separation techniques for neuropeptide identification in biological samples is illustrated. The amino acid sequence information that is important for the identification and analysis of known, novel, or chemically modified neuropeptides may be obtained using mass spectrometric techniques. Because mass spectrometry techniques can be used to reflect the dynamic properties associated with neuropeptide processing in biological systems, they may be used in the future to monitor peptide profiles within organisms... (More)

This review focuses on the contributions of modern mass spectrometry to neuropeptide research. An introduction to newer mass spectrometric techniques is provided. Also, the use of mass spectrometry in combination with high-resolution separation techniques for neuropeptide identification in biological samples is illustrated. The amino acid sequence information that is important for the identification and analysis of known, novel, or chemically modified neuropeptides may be obtained using mass spectrometric techniques. Because mass spectrometry techniques can be used to reflect the dynamic properties associated with neuropeptide processing in biological systems, they may be used in the future to monitor peptide profiles within organisms in response to environmental challenges such as disease and stress.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Mass Spectrometry, Neurochemistry, Neuropeptides, Specimen Handling, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Journal Article, Research Support, Non-U.S. Gov't, Review
in
Peptides
volume
19
issue
4
pages
9 - 781
publisher
Elsevier
external identifiers
  • scopus:0032051626
ISSN
0196-9781
DOI
10.1016/S0196-9781(97)00471-3
language
English
LU publication?
no
id
9a56056b-977e-4a8d-bbe6-d1fda9f56898
date added to LUP
2017-05-16 10:49:07
date last changed
2017-05-21 05:01:42
@article{9a56056b-977e-4a8d-bbe6-d1fda9f56898,
  abstract     = {<p>This review focuses on the contributions of modern mass spectrometry to neuropeptide research. An introduction to newer mass spectrometric techniques is provided. Also, the use of mass spectrometry in combination with high-resolution separation techniques for neuropeptide identification in biological samples is illustrated. The amino acid sequence information that is important for the identification and analysis of known, novel, or chemically modified neuropeptides may be obtained using mass spectrometric techniques. Because mass spectrometry techniques can be used to reflect the dynamic properties associated with neuropeptide processing in biological systems, they may be used in the future to monitor peptide profiles within organisms in response to environmental challenges such as disease and stress.</p>},
  author       = {Nilsson, Carol and Karlsson, G and Bergquist, J and Westman, A. and Ekman, R},
  issn         = {0196-9781},
  keyword      = {Mass Spectrometry,Neurochemistry,Neuropeptides,Specimen Handling,Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization,Journal Article,Research Support, Non-U.S. Gov't,Review},
  language     = {eng},
  number       = {4},
  pages        = {9--781},
  publisher    = {Elsevier},
  series       = {Peptides},
  title        = {Mass spectrometry of peptides in neuroscience},
  url          = {http://dx.doi.org/10.1016/S0196-9781(97)00471-3},
  volume       = {19},
  year         = {1998},
}