Mass spectrometry of peptides in neuroscience
(1998) In Peptides 19(4). p.9-781- Abstract
This review focuses on the contributions of modern mass spectrometry to neuropeptide research. An introduction to newer mass spectrometric techniques is provided. Also, the use of mass spectrometry in combination with high-resolution separation techniques for neuropeptide identification in biological samples is illustrated. The amino acid sequence information that is important for the identification and analysis of known, novel, or chemically modified neuropeptides may be obtained using mass spectrometric techniques. Because mass spectrometry techniques can be used to reflect the dynamic properties associated with neuropeptide processing in biological systems, they may be used in the future to monitor peptide profiles within organisms... (More)
This review focuses on the contributions of modern mass spectrometry to neuropeptide research. An introduction to newer mass spectrometric techniques is provided. Also, the use of mass spectrometry in combination with high-resolution separation techniques for neuropeptide identification in biological samples is illustrated. The amino acid sequence information that is important for the identification and analysis of known, novel, or chemically modified neuropeptides may be obtained using mass spectrometric techniques. Because mass spectrometry techniques can be used to reflect the dynamic properties associated with neuropeptide processing in biological systems, they may be used in the future to monitor peptide profiles within organisms in response to environmental challenges such as disease and stress.
(Less)
- author
- Nilsson, Carol LU ; Karlsson, G ; Bergquist, J ; Westman, A. and Ekman, R
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- keywords
- Mass Spectrometry, Neurochemistry, Neuropeptides, Specimen Handling, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Journal Article, Research Support, Non-U.S. Gov't, Review
- in
- Peptides
- volume
- 19
- issue
- 4
- pages
- 9 - 781
- publisher
- Elsevier
- external identifiers
-
- pmid:9622036
- scopus:0032051626
- ISSN
- 0196-9781
- DOI
- 10.1016/S0196-9781(97)00471-3
- language
- English
- LU publication?
- no
- id
- 9a56056b-977e-4a8d-bbe6-d1fda9f56898
- date added to LUP
- 2017-05-16 10:49:07
- date last changed
- 2024-01-13 21:04:52
@article{9a56056b-977e-4a8d-bbe6-d1fda9f56898,
abstract = {{<p>This review focuses on the contributions of modern mass spectrometry to neuropeptide research. An introduction to newer mass spectrometric techniques is provided. Also, the use of mass spectrometry in combination with high-resolution separation techniques for neuropeptide identification in biological samples is illustrated. The amino acid sequence information that is important for the identification and analysis of known, novel, or chemically modified neuropeptides may be obtained using mass spectrometric techniques. Because mass spectrometry techniques can be used to reflect the dynamic properties associated with neuropeptide processing in biological systems, they may be used in the future to monitor peptide profiles within organisms in response to environmental challenges such as disease and stress.</p>}},
author = {{Nilsson, Carol and Karlsson, G and Bergquist, J and Westman, A. and Ekman, R}},
issn = {{0196-9781}},
keywords = {{Mass Spectrometry; Neurochemistry; Neuropeptides; Specimen Handling; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Journal Article; Research Support, Non-U.S. Gov't; Review}},
language = {{eng}},
number = {{4}},
pages = {{9--781}},
publisher = {{Elsevier}},
series = {{Peptides}},
title = {{Mass spectrometry of peptides in neuroscience}},
url = {{http://dx.doi.org/10.1016/S0196-9781(97)00471-3}},
doi = {{10.1016/S0196-9781(97)00471-3}},
volume = {{19}},
year = {{1998}},
}