Two-step production of monoamines in monoenzymatic cells in the spinal cord : A different control strategy of neurotransmitter supply?
(2016) In Neural Regeneration Research 11(12). p.1904-1909- Abstract
Monoamine neurotransmitters play an important role in the modulation of sensory, motor and autonomic functions in the spinal cord. Although traditionally it is believed that in mammalian spinal cord, monoamine neurotransmitters mainly originate from the brain, accumulating evidence indicates that especially when the spinal cord is injured, they can also be produced in the spinal cord. In this review, I will present evidence for a possible pathway for two-step synthesis of dopamine and serotonin in the spinal cord. Published data from different sources and unpublished data from my own ongoing projects indicate that monoenzymatic cells expressing aromatic L-amino acid decarboxylase (AADC), tyrosine hydroxylase (TH) or tryptophan... (More)
Monoamine neurotransmitters play an important role in the modulation of sensory, motor and autonomic functions in the spinal cord. Although traditionally it is believed that in mammalian spinal cord, monoamine neurotransmitters mainly originate from the brain, accumulating evidence indicates that especially when the spinal cord is injured, they can also be produced in the spinal cord. In this review, I will present evidence for a possible pathway for two-step synthesis of dopamine and serotonin in the spinal cord. Published data from different sources and unpublished data from my own ongoing projects indicate that monoenzymatic cells expressing aromatic L-amino acid decarboxylase (AADC), tyrosine hydroxylase (TH) or tryptophan hydroxylase (TPH) are present in the spinal cord and that these TH and THP cells often lie in close proximity to AADC cells. Prompted by the above evidence, I hypothesize that dopamine and serotonin could be synthesized sequentially in two monoenzymatic cells in the spinal cord via a TH-AADC and a TPH-AADC cascade respectively. The monoamines synthesized through this pathway may compensate for lost neurotransmitters following spinal cord injury and also may play specific roles in the recovery of sensory, motor and autonomic functions.
(Less)
- author
- Zhang, Mengliang LU
- organization
- publishing date
- 2016-12-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 5-hydroxytryptophan, Aromatic L-amino acid decarboxylase, Dopamine, L-dopa, Monoamine precursor, Non-monoaminergic cell, Serotonin, Spinal cord injury, Tryptophan hydroxylase, Tyrosine hydroxylase
- in
- Neural Regeneration Research
- volume
- 11
- issue
- 12
- pages
- 6 pages
- publisher
- Shenyang Editorial Dept Neural Regeneration Res
- external identifiers
-
- scopus:85009204478
- pmid:28197177
- wos:000393890900006
- ISSN
- 1673-5374
- DOI
- 10.4103/1673-5374.197124
- language
- English
- LU publication?
- yes
- id
- 9a61eb3f-8c54-482b-b9ab-17e99c703a0d
- date added to LUP
- 2017-01-27 07:09:38
- date last changed
- 2024-04-05 15:31:23
@article{9a61eb3f-8c54-482b-b9ab-17e99c703a0d,
abstract = {{<p>Monoamine neurotransmitters play an important role in the modulation of sensory, motor and autonomic functions in the spinal cord. Although traditionally it is believed that in mammalian spinal cord, monoamine neurotransmitters mainly originate from the brain, accumulating evidence indicates that especially when the spinal cord is injured, they can also be produced in the spinal cord. In this review, I will present evidence for a possible pathway for two-step synthesis of dopamine and serotonin in the spinal cord. Published data from different sources and unpublished data from my own ongoing projects indicate that monoenzymatic cells expressing aromatic L-amino acid decarboxylase (AADC), tyrosine hydroxylase (TH) or tryptophan hydroxylase (TPH) are present in the spinal cord and that these TH and THP cells often lie in close proximity to AADC cells. Prompted by the above evidence, I hypothesize that dopamine and serotonin could be synthesized sequentially in two monoenzymatic cells in the spinal cord via a TH-AADC and a TPH-AADC cascade respectively. The monoamines synthesized through this pathway may compensate for lost neurotransmitters following spinal cord injury and also may play specific roles in the recovery of sensory, motor and autonomic functions.</p>}},
author = {{Zhang, Mengliang}},
issn = {{1673-5374}},
keywords = {{5-hydroxytryptophan; Aromatic L-amino acid decarboxylase; Dopamine; L-dopa; Monoamine precursor; Non-monoaminergic cell; Serotonin; Spinal cord injury; Tryptophan hydroxylase; Tyrosine hydroxylase}},
language = {{eng}},
month = {{12}},
number = {{12}},
pages = {{1904--1909}},
publisher = {{Shenyang Editorial Dept Neural Regeneration Res}},
series = {{Neural Regeneration Research}},
title = {{Two-step production of monoamines in monoenzymatic cells in the spinal cord : A different control strategy of neurotransmitter supply?}},
url = {{http://dx.doi.org/10.4103/1673-5374.197124}},
doi = {{10.4103/1673-5374.197124}},
volume = {{11}},
year = {{2016}},
}