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Association between Parkinson’s Disease and Diabetes Mellitus : From Epidemiology, Pathophysiology and Prevention to Treatment

Yu, Haiyang ; Sun, Tong ; He, Xin ; Wang, Zhen ; Zhao, Kaidong ; An, Jing ; Wen, Lulu ; Li, Jia Yi LU ; Li, Wen LU and Feng, Juan (2022) In Aging and Disease 13(6). p.1591-1605
Abstract

Diabetes mellitus (DM) and Parkinson’s disease (PD) are both age-related diseases of global concern being among the most common chronic metabolic and neurodegenerative diseases, respectively. While both diseases can be genetically inherited, environmental factors play a vital role in their pathogenesis. Moreover, DM and PD have common underlying molecular mechanisms, such as misfolded protein aggregation, mitochondrial dysfunction, oxidative stress, chronic inflammation, and microbial dysbiosis. Recently, epidemiological and experimental studies have reported that DM affects the incidence and progression of PD. Moreover, certain antidiabetic drugs have been proven to decrease the risk of PD and delay its progression. In this review, we... (More)

Diabetes mellitus (DM) and Parkinson’s disease (PD) are both age-related diseases of global concern being among the most common chronic metabolic and neurodegenerative diseases, respectively. While both diseases can be genetically inherited, environmental factors play a vital role in their pathogenesis. Moreover, DM and PD have common underlying molecular mechanisms, such as misfolded protein aggregation, mitochondrial dysfunction, oxidative stress, chronic inflammation, and microbial dysbiosis. Recently, epidemiological and experimental studies have reported that DM affects the incidence and progression of PD. Moreover, certain antidiabetic drugs have been proven to decrease the risk of PD and delay its progression. In this review, we elucidate the epidemiological and pathophysiological association between DM and PD and summarize the antidiabetic drugs used in animal models and clinical trials of PD, which may provide reference for the clinical translation of antidiabetic drugs in PD treatment.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antidiabetic drugs, diabetes mellitus, epidemiology, Parkinson’s disease, pathophysiology, treatment
in
Aging and Disease
volume
13
issue
6
pages
15 pages
publisher
Buck Institute for Age Research
external identifiers
  • pmid:36465171
  • scopus:85143209974
ISSN
2152-5250
DOI
10.14336/AD.2022.0325
language
English
LU publication?
yes
id
9a79c923-59d0-4a17-a6c1-63f30baf7964
date added to LUP
2022-12-23 10:48:38
date last changed
2024-07-10 01:14:10
@article{9a79c923-59d0-4a17-a6c1-63f30baf7964,
  abstract     = {{<p>Diabetes mellitus (DM) and Parkinson’s disease (PD) are both age-related diseases of global concern being among the most common chronic metabolic and neurodegenerative diseases, respectively. While both diseases can be genetically inherited, environmental factors play a vital role in their pathogenesis. Moreover, DM and PD have common underlying molecular mechanisms, such as misfolded protein aggregation, mitochondrial dysfunction, oxidative stress, chronic inflammation, and microbial dysbiosis. Recently, epidemiological and experimental studies have reported that DM affects the incidence and progression of PD. Moreover, certain antidiabetic drugs have been proven to decrease the risk of PD and delay its progression. In this review, we elucidate the epidemiological and pathophysiological association between DM and PD and summarize the antidiabetic drugs used in animal models and clinical trials of PD, which may provide reference for the clinical translation of antidiabetic drugs in PD treatment.</p>}},
  author       = {{Yu, Haiyang and Sun, Tong and He, Xin and Wang, Zhen and Zhao, Kaidong and An, Jing and Wen, Lulu and Li, Jia Yi and Li, Wen and Feng, Juan}},
  issn         = {{2152-5250}},
  keywords     = {{antidiabetic drugs; diabetes mellitus; epidemiology; Parkinson’s disease; pathophysiology; treatment}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{6}},
  pages        = {{1591--1605}},
  publisher    = {{Buck Institute for Age Research}},
  series       = {{Aging and Disease}},
  title        = {{Association between Parkinson’s Disease and Diabetes Mellitus : From Epidemiology, Pathophysiology and Prevention to Treatment}},
  url          = {{http://dx.doi.org/10.14336/AD.2022.0325}},
  doi          = {{10.14336/AD.2022.0325}},
  volume       = {{13}},
  year         = {{2022}},
}