State of the Art in Sub-Phenotyping Midbrain Dopamine Neurons
Basso, Valentina ; Döbrössy, Máté D. ; Thompson, Lachlan H. ; Kirik, Deniz LU
; Fuller, Heidi R.
and Gates, Monte A.
(2024)
In Biology
13(9).
- Abstract
Dopaminergic neurons in the ventral tegmental area (VTA) and the substantia nigra pars compacta (SNpc) comprise around 75% of all dopaminergic neurons in the human brain. While both groups of dopaminergic neurons are in close proximity in the midbrain and partially overlap, development, function, and impairments in these two classes of neurons are highly diverse. The molecular and cellular mechanisms underlying these differences are not yet fully understood, but research over the past decade has highlighted the need to differentiate between these two classes of dopaminergic neurons during their development and in the mature brain. This differentiation is crucial not only for understanding fundamental circuitry formation in the brain but... (More)
Dopaminergic neurons in the ventral tegmental area (VTA) and the substantia nigra pars compacta (SNpc) comprise around 75% of all dopaminergic neurons in the human brain. While both groups of dopaminergic neurons are in close proximity in the midbrain and partially overlap, development, function, and impairments in these two classes of neurons are highly diverse. The molecular and cellular mechanisms underlying these differences are not yet fully understood, but research over the past decade has highlighted the need to differentiate between these two classes of dopaminergic neurons during their development and in the mature brain. This differentiation is crucial not only for understanding fundamental circuitry formation in the brain but also for developing therapies targeted to specific dopaminergic neuron classes without affecting others. In this review, we summarize the state of the art in our understanding of the differences between the dopaminergic neurons of the VTA and the SNpc, such as anatomy, structure, morphology, output and input, electrophysiology, development, and disorders, and discuss the current technologies and methods available for studying these two classes of dopaminergic neurons, highlighting their advantages, limitations, and the necessary improvements required to achieve more-precise therapeutic interventions.
(Less)
- author
- Basso, Valentina
; Döbrössy, Máté D.
; Thompson, Lachlan H.
; Kirik, Deniz
LU
; Fuller, Heidi R.
and Gates, Monte A.
- organization
- publishing date
- 2024-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- dopamine (DA), drug addiction, major depression, midbrain dopaminergic neurons (mDA), Parkinson’s disease (PD), schizophrenia (SZ), substantia nigra pars compacta (SNpc), ventral tegmental area (VTA)
- in
- Biology
- volume
- 13
- issue
- 9
- article number
- 690
- publisher
- MDPI AG
- external identifiers
-
- pmid:39336117
- scopus:85205124801
- ISSN
- 2079-7737
- DOI
- 10.3390/biology13090690
- language
- English
- LU publication?
- yes
- id
- 9b072f88-8e20-4a01-b243-ace61ba0ba45
- date added to LUP
- 2024-12-18 12:51:46
- date last changed
- 2025-05-07 23:05:09
@article{9b072f88-8e20-4a01-b243-ace61ba0ba45,
abstract = {{<p>Dopaminergic neurons in the ventral tegmental area (VTA) and the substantia nigra pars compacta (SNpc) comprise around 75% of all dopaminergic neurons in the human brain. While both groups of dopaminergic neurons are in close proximity in the midbrain and partially overlap, development, function, and impairments in these two classes of neurons are highly diverse. The molecular and cellular mechanisms underlying these differences are not yet fully understood, but research over the past decade has highlighted the need to differentiate between these two classes of dopaminergic neurons during their development and in the mature brain. This differentiation is crucial not only for understanding fundamental circuitry formation in the brain but also for developing therapies targeted to specific dopaminergic neuron classes without affecting others. In this review, we summarize the state of the art in our understanding of the differences between the dopaminergic neurons of the VTA and the SNpc, such as anatomy, structure, morphology, output and input, electrophysiology, development, and disorders, and discuss the current technologies and methods available for studying these two classes of dopaminergic neurons, highlighting their advantages, limitations, and the necessary improvements required to achieve more-precise therapeutic interventions.</p>}},
author = {{Basso, Valentina and Döbrössy, Máté D. and Thompson, Lachlan H. and Kirik, Deniz and Fuller, Heidi R. and Gates, Monte A.}},
issn = {{2079-7737}},
keywords = {{dopamine (DA); drug addiction; major depression; midbrain dopaminergic neurons (mDA); Parkinson’s disease (PD); schizophrenia (SZ); substantia nigra pars compacta (SNpc); ventral tegmental area (VTA)}},
language = {{eng}},
number = {{9}},
publisher = {{MDPI AG}},
series = {{Biology}},
title = {{State of the Art in Sub-Phenotyping Midbrain Dopamine Neurons}},
url = {{http://dx.doi.org/10.3390/biology13090690}},
doi = {{10.3390/biology13090690}},
volume = {{13}},
year = {{2024}},
}