RIFM fragrance ingredient safety assessment, 1,1-diethoxyheptane, CAS Registry Number 688-82-4
(2018) In Food and Chemical Toxicology 122(Suppl. 1). p.558-565- Abstract
The use of this material under current conditions is supported by existing information. 1,1-Diethoxyheptane was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from the read-across analog octanal dimethyl acetal (CAS # 10022-28-3) show that 1,1-diethoxyheptane is not expected to be genotoxic. Based on the application of the non-reactive DST, 1,1-diethoxyheptane does not present a concern for skin sensitization. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were completed using the TTC for a Cramer Class I material (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4... (More)
The use of this material under current conditions is supported by existing information. 1,1-Diethoxyheptane was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from the read-across analog octanal dimethyl acetal (CAS # 10022-28-3) show that 1,1-diethoxyheptane is not expected to be genotoxic. Based on the application of the non-reactive DST, 1,1-diethoxyheptane does not present a concern for skin sensitization. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were completed using the TTC for a Cramer Class I material (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoint was completed based on UV spectra. The environmental endpoints were evaluated; 1,1-diethoxyheptane was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.
(Less)
- author
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Food and Chemical Toxicology
- volume
- 122
- issue
- Suppl. 1
- pages
- 558 - 565
- publisher
- Elsevier
- external identifiers
-
- scopus:85054608406
- pmid:30300725
- ISSN
- 0278-6915
- DOI
- 10.1016/j.fct.2018.10.019
- language
- English
- LU publication?
- no
- id
- 9b15a2a7-e648-4ae2-a42d-749fcf54f4eb
- date added to LUP
- 2018-12-10 09:48:19
- date last changed
- 2024-10-01 12:13:54
@article{9b15a2a7-e648-4ae2-a42d-749fcf54f4eb, abstract = {{<p>The use of this material under current conditions is supported by existing information. 1,1-Diethoxyheptane was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from the read-across analog octanal dimethyl acetal (CAS # 10022-28-3) show that 1,1-diethoxyheptane is not expected to be genotoxic. Based on the application of the non-reactive DST, 1,1-diethoxyheptane does not present a concern for skin sensitization. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were completed using the TTC for a Cramer Class I material (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoint was completed based on UV spectra. The environmental endpoints were evaluated; 1,1-diethoxyheptane was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.</p>}}, author = {{Api, A. M. and Belsito, D. and Botelho, D. and Bruze, M. and Burton, G. A. and Buschmann, J. and Dagli, M. L. and Date, M. and Dekant, W. and Deodhar, C. and Francis, M. and Fryer, A. D. and Jones, L. and Joshi, K. and La Cava, S. and Lapczynski, A. and Liebler, D. C. and O'Brien, D. and Patel, A. and Penning, T. M. and Ritacco, G. and Romine, J. and Sadekar, N. and Salvito, D. and Schultz, T. W. and Sipes, I. G. and Sullivan, G. and Thakkar, Y. and Tokura, Y. and Tsang, S.}}, issn = {{0278-6915}}, language = {{eng}}, number = {{Suppl. 1}}, pages = {{558--565}}, publisher = {{Elsevier}}, series = {{Food and Chemical Toxicology}}, title = {{RIFM fragrance ingredient safety assessment, 1,1-diethoxyheptane, CAS Registry Number 688-82-4}}, url = {{http://dx.doi.org/10.1016/j.fct.2018.10.019}}, doi = {{10.1016/j.fct.2018.10.019}}, volume = {{122}}, year = {{2018}}, }