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[Aldosterone reception by a kidney membrane fraction and cytosol from rats in postnatal ontogeny]

Logvinenko, N S ; Svitasheva, N G LU ; Solenov, E I and Ivanova, L N (1989) In Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova 75(2). p.6-251
Abstract

Specific binding of aldosterone by crude membrane fraction, the affinity and maximal concentration of cytosolic receptors of aldosterone were studied in the kidney cortex of the Wistar rats as well as the plasma level and adrenal biosynthesis of aldosterone. The specific binding of aldosterone was found to increase in membrane fraction and to decrease in cytosol during kidney maturation. The affinity of the cytosol receptors to aldosterone did not change in the same period. The level of biosynthesis in adrenals and plasma concentration of aldosterone was higher in adult rather than in young rats. The membrane binding of aldosterone seems to take part in the mechanism of cell sensitivity to aldosterone.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adrenal Glands/metabolism, Aging/metabolism, Aldosterone/analysis, Animals, Cell Membrane/metabolism, Cytosol/metabolism, Kidney/metabolism, Male, Rats, Rats, Inbred Strains, Receptors, Glucocorticoid/analysis, Receptors, Mineralocorticoid, Tritium
in
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova
volume
75
issue
2
pages
6 - 251
publisher
Izdatel'stvo Nauka
external identifiers
  • pmid:2524409
  • scopus:0024615014
ISSN
0015-329X
language
English
LU publication?
no
id
9b16bc37-31c2-4f51-a9c7-7e4bb614eea0
date added to LUP
2020-03-02 08:58:53
date last changed
2024-01-02 06:57:54
@article{9b16bc37-31c2-4f51-a9c7-7e4bb614eea0,
  abstract     = {{<p>Specific binding of aldosterone by crude membrane fraction, the affinity and maximal concentration of cytosolic receptors of aldosterone were studied in the kidney cortex of the Wistar rats as well as the plasma level and adrenal biosynthesis of aldosterone. The specific binding of aldosterone was found to increase in membrane fraction and to decrease in cytosol during kidney maturation. The affinity of the cytosol receptors to aldosterone did not change in the same period. The level of biosynthesis in adrenals and plasma concentration of aldosterone was higher in adult rather than in young rats. The membrane binding of aldosterone seems to take part in the mechanism of cell sensitivity to aldosterone.</p>}},
  author       = {{Logvinenko, N S and Svitasheva, N G and Solenov, E I and Ivanova, L N}},
  issn         = {{0015-329X}},
  keywords     = {{Adrenal Glands/metabolism; Aging/metabolism; Aldosterone/analysis; Animals; Cell Membrane/metabolism; Cytosol/metabolism; Kidney/metabolism; Male; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid/analysis; Receptors, Mineralocorticoid; Tritium}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{6--251}},
  publisher    = {{Izdatel'stvo Nauka}},
  series       = {{Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova}},
  title        = {{[Aldosterone reception by a kidney membrane fraction and cytosol from rats in postnatal ontogeny]}},
  volume       = {{75}},
  year         = {{1989}},
}