Serum concentrations of human chorionic gonadotropin beta and its association with survival in patients with colorectal cancer
Birgisson, Helgi ; Jirström, Karin LU
and Stenman, Ulf-Hakan
(2012)
In Cancer Biomarkers
11(4).
p.173-181
- Abstract
- Increased serum concentrations of the beta subunit of human chorionic gonadotropin (hCG beta) are associated with adverse prognosis in several cancers. The aim of the present study was to analyse the association between serum hCG beta recurrence, and survival, in patients with colorectal cancer. The concentrations of hCG beta were determined in serum collected preoperatively from 324 patients with colorectal cancer, of whom 270 were curatively treated. The serum concentrations of hCG beta were associated with increasing age and they were higher in women than in men. Using the 75th percentile (1.55 pmol/L) as a cut-off for serum hCG beta, overall survival (OS) was shorter in patients with elevated concentrations (HR 1.95; 95% CI 1.39-2.74;... (More)
- Increased serum concentrations of the beta subunit of human chorionic gonadotropin (hCG beta) are associated with adverse prognosis in several cancers. The aim of the present study was to analyse the association between serum hCG beta recurrence, and survival, in patients with colorectal cancer. The concentrations of hCG beta were determined in serum collected preoperatively from 324 patients with colorectal cancer, of whom 270 were curatively treated. The serum concentrations of hCG beta were associated with increasing age and they were higher in women than in men. Using the 75th percentile (1.55 pmol/L) as a cut-off for serum hCG beta, overall survival (OS) was shorter in patients with elevated concentrations (HR 1.95; 95% CI 1.39-2.74; P = 0.004), and this association was stronger in women (P = 0.022) than in men (P = 0.061). In multivariate analyses including age, disease stage, tumour differentiation, vascular invasion and CEA, high serum hCG beta concentrations remained an independent prognostic factor for adverse OS in women (HR 2.26; 95% CI 1.39-3.67), but not in men (HR 0.78; 95% CI 0.41-1.51). The same trend was observed for disease free-and cancer specific survival. High serum concentration of hCG beta is an independent prognostic factor for adverse outcome in women with colorectal cancer. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3256195
- author
- Birgisson, Helgi
; Jirström, Karin
LU
and Stenman, Ulf-Hakan
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cancer, colorectal, human chorionic gonadotropin beta, hCG, prognosis, survival
- in
- Cancer Biomarkers
- volume
- 11
- issue
- 4
- pages
- 173 - 181
- publisher
- IOS Press
- external identifiers
-
- wos:000310980000006
- scopus:84871582252
- pmid:23144155
- ISSN
- 1875-8592
- DOI
- 10.3233/CBM-2012-00279
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)
- id
- 9b3deb3d-47e9-49a6-a1e3-ff5f248341f3 (old id 3256195)
- date added to LUP
- 2016-04-01 10:05:28
- date last changed
- 2024-01-06 07:11:58
@article{9b3deb3d-47e9-49a6-a1e3-ff5f248341f3,
abstract = {{Increased serum concentrations of the beta subunit of human chorionic gonadotropin (hCG beta) are associated with adverse prognosis in several cancers. The aim of the present study was to analyse the association between serum hCG beta recurrence, and survival, in patients with colorectal cancer. The concentrations of hCG beta were determined in serum collected preoperatively from 324 patients with colorectal cancer, of whom 270 were curatively treated. The serum concentrations of hCG beta were associated with increasing age and they were higher in women than in men. Using the 75th percentile (1.55 pmol/L) as a cut-off for serum hCG beta, overall survival (OS) was shorter in patients with elevated concentrations (HR 1.95; 95% CI 1.39-2.74; P = 0.004), and this association was stronger in women (P = 0.022) than in men (P = 0.061). In multivariate analyses including age, disease stage, tumour differentiation, vascular invasion and CEA, high serum hCG beta concentrations remained an independent prognostic factor for adverse OS in women (HR 2.26; 95% CI 1.39-3.67), but not in men (HR 0.78; 95% CI 0.41-1.51). The same trend was observed for disease free-and cancer specific survival. High serum concentration of hCG beta is an independent prognostic factor for adverse outcome in women with colorectal cancer.}},
author = {{Birgisson, Helgi and Jirström, Karin and Stenman, Ulf-Hakan}},
issn = {{1875-8592}},
keywords = {{Cancer; colorectal; human chorionic gonadotropin beta; hCG; prognosis; survival}},
language = {{eng}},
number = {{4}},
pages = {{173--181}},
publisher = {{IOS Press}},
series = {{Cancer Biomarkers}},
title = {{Serum concentrations of human chorionic gonadotropin beta and its association with survival in patients with colorectal cancer}},
url = {{http://dx.doi.org/10.3233/CBM-2012-00279}},
doi = {{10.3233/CBM-2012-00279}},
volume = {{11}},
year = {{2012}},
}